Reactome | MAP2K7,MAP2K4 [cytosol]

MAP2K7,MAP2K4 [cytosol]

Stable Identifier

R-HSA-450305

Type

Set [DefinedSet]

Species

Homo sapiens

Compartment

cytosol

Synonyms

MKK4, MKK7

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-17 signaling (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
        
        MAP2K7,MAP2K4 [cytosol] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
        
        MAP2K7,MAP2K4 [cytosol] (Homo sapiens)
    - Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
      - Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
        
        MAP2K7,MAP2K4 [cytosol] (Homo sapiens)
      - Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
        
        MAP2K7,MAP2K4 [cytosol] (Homo sapiens)
    - Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
        
        MAP2K7,MAP2K4 [cytosol] (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
        
        MAP2K7,MAP2K4 [cytosol] (Homo sapiens)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
        
        MAP2K7,MAP2K4 [cytosol] (Homo sapiens)
    - Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
        
        MAP2K7,MAP2K4 [cytosol] (Homo sapiens)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
        
        MAP2K7,MAP2K4 [cytosol] (Homo sapiens)
    - Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
        
        MAP2K7,MAP2K4 [cytosol] (Homo sapiens)

Participants

members

Participates

as an input of

Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)

Inferred To

MAP2K4 [cytosol] (Bos taurus)

MAP2K4 [cytosol] (Caenorhabditis elegans)

MAP2K4 [cytosol] (Drosophila melanogaster)

MAP2K4 [cytosol] (Gallus gallus)

MAP2K4 [cytosol] (Sus scrofa)

MAP2K4 [cytosol] (Xenopus tropicalis)

MAP2K7,MAP2K4 [cytosol] (Canis familiaris)

MAP2K7,MAP2K4 [cytosol] (Danio rerio)

MAP2K7,MAP2K4 [cytosol] (Dictyostelium discoideum)

MAP2K7,MAP2K4 [cytosol] (Mus musculus)

MAP2K7,MAP2K4 [cytosol] (Rattus norvegicus)