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RIPK1 [endosome membrane]
Stable Identifier
R-HSA-450326
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endosome membrane
Synonyms
RIP1, receptor interacting protein 1
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
ZBP1(DAI) mediated induction of type I IFNs (Homo sapiens)
RIP-mediated NFkB activation via ZBP1 (Homo sapiens)
RIP1 facilitates IKK complex phosphorylation (Homo sapiens)
viral dsRNA:TLR3:TICAM1:RIPK1 [endosome membrane] (Homo sapiens)
RIPK1 [endosome membrane] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TICAM1, RIP1-mediated IKK complex recruitment (Homo sapiens)
K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Homo sapiens)
viral dsRNA:TLR3:TICAM1:RIPK1 [endosome membrane] (Homo sapiens)
RIPK1 [endosome membrane] (Homo sapiens)
Viral dsRNA:TLR3:TRIF complex recruits RIP1 (Homo sapiens)
viral dsRNA:TLR3:TICAM1:RIPK1 [endosome membrane] (Homo sapiens)
RIPK1 [endosome membrane] (Homo sapiens)
TLR3-mediated TICAM1-dependent programmed cell death (Homo sapiens)
RIP3 binds TICAM1 within TLR3 complex to mediate necroptosis (Homo sapiens)
RIP3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1:RIPK1:RIPK3 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1:RIPK1 [endosome membrane] (Homo sapiens)
RIPK1 [endosome membrane] (Homo sapiens)
TICAM1:activated TLR3 complexes [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1:RIPK1 [endosome membrane] (Homo sapiens)
RIPK1 [endosome membrane] (Homo sapiens)
TLR3-induced ripoptosome assembly (Homo sapiens)
viral dsRNA:TLR3:TICAM1:RIPK1 [endosome membrane] (Homo sapiens)
RIPK1 [endosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13546 RIPK1
Gene Names
RIPK1, RIP, RIP1
Chain
chain:1-671
Reference Genes
BioGPS Gene:8737 RIPK1
COSMIC (genes):RIPK1 RIPK1
CTD Gene:8737 RIPK1
dbSNP Gene:8737 RIPK1
ENSEMBL:ENSG00000137275 RIPK1
ENSEMBL_homo_sapiens_GENE:ENSG00000137275.16 RIPK1
HGNC:10019 RIPK1
KEGG Gene (Homo sapiens):8737 RIPK1
Monarch:8737 RIPK1
NCBI Gene:8737 RIPK1
OMIM:603453 RIPK1
UCSC:Q13546 RIPK1
Reference Transcript
RefSeq:NM_003804.4 RIPK1
RefSeq:XM_005249457.3 RIPK1
Other Identifiers
11737938_a_at
11737939_a_at
11737940_s_at
11750849_a_at
11756807_a_at
17004295
209941_PM_at
209941_at
226551_PM_at
226551_at
2892343
2892344
2892345
2892349
2892350
2892352
2892355
2892356
2892357
2892358
2892359
2892363
2892364
2892372
2892373
2892375
2892376
2892377
2892378
2892379
2892383
2892385
2892386
2892387
2892388
2892389
2939062
2939063
40696_at
475_at
51161_at
8116622
8737
A_23_P370005
A_33_P3279059
GO:0000165
GO:0000166
GO:0001934
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004706
GO:0005123
GO:0005515
GO:0005524
GO:0005737
GO:0005739
GO:0005768
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006468
GO:0006915
GO:0006950
GO:0006954
GO:0006979
GO:0007165
GO:0008152
GO:0010008
GO:0010628
GO:0012501
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0030154
GO:0030163
GO:0031047
GO:0031264
GO:0031349
GO:0031410
GO:0031625
GO:0032103
GO:0032757
GO:0032760
GO:0032991
GO:0033209
GO:0034612
GO:0035556
GO:0035591
GO:0036211
GO:0036289
GO:0042327
GO:0042802
GO:0042803
GO:0043065
GO:0043066
GO:0043068
GO:0043123
GO:0043124
GO:0043226
GO:0043235
GO:0043410
GO:0043525
GO:0044877
GO:0045651
GO:0045944
GO:0046330
GO:0046777
GO:0048856
GO:0050729
GO:0051092
GO:0055085
GO:0060090
GO:0060545
GO:0060546
GO:0062100
GO:0065003
GO:0070105
GO:0070231
GO:0070266
GO:0070301
GO:0070513
GO:0070926
GO:0071345
GO:0071356
GO:0071363
GO:0097191
GO:0097300
GO:0097342
GO:0097343
GO:0097527
GO:0106310
GO:0140096
GO:1900119
GO:1901026
GO:1901224
GO:1903265
GO:1903800
GO:1990000
GO:2000377
GO:2000379
GO:2001237
GO:2001238
GO:2001240
HMNXSV003025407
HMNXSV003028067
Hs.77273.1.A1_3p_at
Hs.77273.1.A1_3p_x_at
ILMN_2119535
PH_hs_0018906
TC06000023.hg
TC06002463.hg
U50062_at
g3426026_3p_at
Participates
as a component of
viral dsRNA:TLR3:TICAM1:RIPK1 [endosome membrane] (Homo sapiens)
Other forms of this molecule
K48polyUb-RIPK1 [cytosol]
PolyUb-RIPK1 [cytosol]
RIPK1 D324N [cytosol]
RIPK1 D324Y [cytosol]
RIPK1 D324V [cytosol]
RIPK1 D324H [cytosol]
RIPK1 [plasma membrane]
K48polyUb-K571,K604,K627-RIPK1 [cytosol]
K63,Met1polyUb-p-S25-RIPK1 [cytosol]
K63,M1polyUb-RIPK1 [cytosol]
RIPK1(1-324) [cytosol]
RIPK1(325-671) [cytosol]
polyUb-K377,K604,K634-RIPK1 [cytosol]
K63,M1polyUb, p-T189-RIPK1 [cytosol]
p-S320-RIPK1 [cytosol]
p-S357-RIPK1 [cytosol]
p-S166-RIPK1 [cytosol]
K63polyUb-RIPK1 [cytosol]
RIPK1 [cytosol]
Cross References
RefSeq
XP_005249514.2
,
NP_003795.2
ZINC - World Drugs
RIPK1_HUMAN
Guide to Pharmacology - Targets
2189
OpenTargets
ENSG00000137275
ZINC - FDA approved
RIPK1_HUMAN
ZINC - Substances
RIPK1_HUMAN
ZINC target
Q13546
PRO
Q13546
PDB
7CJB
,
5HX6
,
5V7Z
,
6HHO
,
4ITJ
,
4NEU
,
6C3E
,
6NW2
,
7XMK
,
5TX5
,
8I2N
,
6R5F
,
7FCZ
,
6NYH
,
6RLN
,
7YDX
,
4ITH
,
6C4D
,
4ITI
,
6AC5
,
6OCQ
,
7FD0
ZINC - Investigational
RIPK1_HUMAN
HPA
ENSG00000137275-RIPK1
GeneCards
Q13546
Ensembl
ENST00000259808
,
ENSP00000259808
,
ENST00000380409
,
ENSP00000369773
,
ENSG00000137275
Pharos - Targets
Q13546
ZINC - Predictions - Purchasable
RIPK1_HUMAN
HMDB Protein
HMDBP09499
Interactors (24)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y572 RIPK3
8
p-S199,227, K48pUb-363-RIPK3 [cytosol]
(R-HSA-9686933)
K33polyUb-K197,302,364-RIPK3 [cytosol]
(R-HSA-9794180)
OGlcNAc-T467-RIPK3 [cytosol]
(R-HSA-9687819)
RIPK3(329-518) [cytosol]
(R-HSA-9686937)
RIPK3(1-328) [cytosol]
(R-HSA-9686917)
RIPK3 [cytosol]
(R-HSA-450328)
p-S199,227-RIPK3 [cytosol]
(R-HSA-5218873)
Ub-K55,363-RIPK3 [cytosol]
(R-HSA-9688825)
0.972
27
UniProt:Q14790 CASP8
8
CASP8(1-374) [cytosol]
(R-HSA-3465404)
CASP8(217-374) [mitochondrial outer membrane]
(R-HSA-351869)
CASP8(385-479) [mitochondrial outer membrane]
(R-HSA-351828)
CASP8(385-479) [cytosol]
(R-HSA-76158)
CASP8(375-384) [cytosol]
(R-HSA-933460)
CASP8(217-374) [cytosol]
(R-HSA-75975)
CASP8(1-216) [cytosol]
(R-HSA-933456)
CASP8(1-479) [cytosol]
(R-HSA-57031)
0.959
30
UniProt:Q13158 FADD
1
FADD [cytosol]
(R-HSA-54639)
0.928
12
UniProt:Q9Y6K9 IKBKG
12
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG [nucleoplasm]
(R-HSA-4755413)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
IKBKG [cytosol]
(R-HSA-168108)
0.893
9
UniProt:Q13546 RIPK1
20
K48polyUb-RIPK1 [cytosol]
(R-HSA-6783308)
PolyUb-RIPK1 [cytosol]
(R-HSA-6783197)
RIPK1 D324N [cytosol]
(R-HSA-9693930)
RIPK1 D324Y [cytosol]
(R-HSA-9693931)
RIPK1 D324V [cytosol]
(R-HSA-9693927)
RIPK1 D324H [cytosol]
(R-HSA-9693922)
RIPK1 [plasma membrane]
(R-HSA-937073)
K48polyUb-K571,K604,K627-RIPK1 [cytosol]
(R-HSA-9796639)
K63,Met1polyUb-p-S25-RIPK1 [cytosol]
(R-HSA-9818793)
K63,M1polyUb-RIPK1 [cytosol]
(R-HSA-9793681)
RIPK1(1-324) [cytosol]
(R-HSA-5212664)
RIPK1(325-671) [cytosol]
(R-HSA-5212671)
polyUb-K377,K604,K634-RIPK1 [cytosol]
(R-HSA-9818391)
K63,M1polyUb, p-T189-RIPK1 [cytosol]
(R-HSA-9817377)
p-S320-RIPK1 [cytosol]
(R-HSA-9815498)
p-S357-RIPK1 [cytosol]
(R-HSA-9819116)
p-S166-RIPK1 [cytosol]
(R-HSA-5218872)
K63polyUb-RIPK1 [cytosol]
(R-HSA-937021)
RIPK1 [endosome membrane]
(R-HSA-450326)
RIPK1 [cytosol]
(R-HSA-168651)
0.892
11
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.884
10
UniProt:P19438 TNFRSF1A
2
TNFRSF1A(41-201) [extracellular region]
(R-HSA-6785048)
TNFRSF1A(30-45) [plasma membrane]
(R-HSA-5675738)
0.877
7
UniProt:P01375 TNF
5
TNF(52-76) [extracellular region]
(R-HSA-8863375)
TNF(1-34) [plasma membrane]
(R-HSA-8863367)
TNF(1-76) [plasma membrane]
(R-HSA-8863120)
TNF(77-233) [extracellular region]
(R-HSA-976821)
TNF(1-233) [plasma membrane]
(R-HSA-66220)
0.837
9
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.798
8
UniProt:P0DTD1-PRO_0000449629 REP
0.788
6
UniProt:Q13114 TRAF3
4
TRAF3 R118W [cytosol]
(R-HSA-5602321)
K48polyUb-TRAF3 [cytosol]
(R-HSA-936556)
TRAF3 [cytosol]
(R-HSA-914241)
K63polyUb-TRAF3 [cytosol]
(R-HSA-936402)
0.703
5
UniProt:Q13490 BIRC2
5
K63polyUb-BIRC2 [cytosol]
(R-HSA-5668512)
BIRC2(1-372) [cytosol]
(R-HSA-202913)
BIRC2(373-618) [cytosol]
(R-HSA-202931)
K48pUb-BIRC2 [cytosol]
(R-HSA-5675479)
BIRC2 [cytosol]
(R-HSA-50847)
0.697
5
UniProt:P48729 CSNK1A1
2
CSNK1A1 [cytosol]
(R-HSA-195263)
CSNK1A1 [cilium]
(R-HSA-5632507)
0.602
5
UniProt:Q13489 BIRC3
3
BIRC3 [cytosol]
(R-HSA-50845)
K48pUb-BIRC3 [cytosol]
(R-HSA-5675478)
K63polyUb-BIRC3 [cytosol]
(R-HSA-5668478)
0.602
3
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.589
2
UniProt:Q15628 TRADD
1
TRADD [cytosol]
(R-HSA-66376)
0.564
3
UniProt:P04083 ANXA1
2
ANXA1 [cytosol]
(R-HSA-5263630)
ANXA1 [extracellular region]
(R-HSA-444539)
0.556
5
IntAct:EBI-4399559 UBIQ
0.544
3
UniProt:Q13107 USP4
1
USP4 [cytosol]
(R-HSA-5212663)
0.524
4
UniProt:Q8IVM0 CCD50
0.524
2
UniProt:O00635 TRIM38
1
TRIM38 [cytosol]
(R-HSA-5624325)
0.508
2
UniProt:B7UI21 NLEB1
0.508
4
UniProt:U5TQE9 U5TQE9
0.499
3
UniProt:Q96AB6 NTAN1
0.499
2
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