Reactome | RIPK3 [cytosol]

RIPK3 [cytosol]

Stable Identifier

R-HSA-450328

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

RIP3

Icon

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of programmed cell death (Homo sapiens)
  - Defective RIPK1-mediated regulated necrosis (Homo sapiens)
    - Microbial modulation of RIPK1-mediated regulated necrosis (Homo sapiens)
      - HSV1 RIR1 binds RIPK3 (Homo sapiens)
        
        HSV1 RIR1:RIPK3 [cytosol] (Homo sapiens)
        
        RIPK3 [cytosol] (Homo sapiens)
        
        RIPK3 [cytosol] (Homo sapiens)
- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-1 Infection (Homo sapiens)
        
        SARS-CoV-1-host interactions (Homo sapiens)
        
        SARS-CoV-1 activates/modulates innate immune responses (Homo sapiens)
        
        SARS-CoV-1 3a tetramerizes (Homo sapiens)
        
        RIPK3:O-glycosyl 3a [plasma membrane] (Homo sapiens)
        
        RIPK3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y572 RIPK3

Gene Names

RIPK3, RIP3

Chain

chain:1-518

Reference Genes

BioGPS Gene:11035 RIPK3

COSMIC (genes):RIPK3 RIPK3

CTD Gene:11035 RIPK3

dbSNP Gene:11035 RIPK3

ENSEMBL:ENSG00000129465 RIPK3

ENSEMBL_homo_sapiens_GENE:ENSG00000129465.16 RIPK3

ENSEMBL_homo_sapiens_GENE:ENSG00000285379.2 RIPK3

HGNC:10021 RIPK3

KEGG Gene (Homo sapiens):11035 RIPK3

Monarch:11035 RIPK3

NCBI Gene:11035 RIPK3

OMIM:605817 RIPK3

UCSC:Q9Y572 RIPK3

Reference Transcript

RefSeq:NM_006871.3 RIPK3

Other Identifiers

11035

11723020_a_at

11747951_a_at

11751012_a_at

16791371

228139_PM_at

228139_at

3558227

3558228

3558229

3558230

3558233

3558234

3558235

3558238

3558239

3558240

3558241

3558243

3558245

3558248

3558249

3558252

3558253

3558254

3558255

54622_at

7978312

A_23_P14559

A_33_P3303291

GE62641

GO:0000166

GO:0001914

GO:0002376

GO:0002819

GO:0003713

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006468

GO:0006915

GO:0007165

GO:0010922

GO:0012501

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0030154

GO:0032147

GO:0032649

GO:0032991

GO:0033077

GO:0036211

GO:0038061

GO:0042802

GO:0042981

GO:0043029

GO:0043226

GO:0044877

GO:0045893

GO:0046006

GO:0046777

GO:0048535

GO:0048536

GO:0048538

GO:0048856

GO:0048870

GO:0051092

GO:0051607

GO:0060545

GO:0070235

GO:0070266

GO:0070301

GO:0072593

GO:0097190

GO:0097300

GO:0097527

GO:0097528

GO:0098542

GO:0106310

GO:0140096

GO:0140110

GO:1990000

GO:2000377

GO:2000379

GO:2000452

GO:2001244

HMNXSV003056618

Hs.268551.0.S1_3p_at

ILMN_1763763

PH_hs_0013735

TC14002317.hg

Participates

as a component of

as an input of

This entity regulates

Negatively

Other forms of this molecule

p-S199,227, K48pUb-363-RIPK3 [cytosol]

K33polyUb-K197,302,364-RIPK3 [cytosol]

OGlcNAc-T467-RIPK3 [cytosol]

RIPK3(329-518) [cytosol]

RIPK3(1-328) [cytosol]

p-S199,227-RIPK3 [cytosol]

Ub-K55,363-RIPK3 [cytosol]

Inferred To

Ghost homologue of RIPK3 [cytosol] (Danio rerio)

Ghost homologue of RIPK3 [cytosol] (Drosophila melanogaster)

Ghost homologue of RIPK3 [cytosol] (Gallus gallus)

Homologues of RIPK3 [cytosol] (Dictyostelium discoideum)

RIPK3 [cytosol] (Bos taurus)

RIPK3 [cytosol] (Canis familiaris)

RIPK3 [cytosol] (Dictyostelium discoideum)

RIPK3 [cytosol] (Mus musculus)

RIPK3 [cytosol] (Rattus norvegicus)

RIPK3 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_006862.2

Guide to Pharmacology - Targets

2191

OpenTargets

ENSG00000129465

IntEnz

2.7.11.1

GeneCards

Q9Y572

HPA

ENSG00000129465-RIPK3

ZINC target

Q9Y572

Ensembl

ENST00000216274, ENST00000646516, ENSP00000495490, ENSG00000285379, ENSP00000495915, ENST00000643393, ENSG00000129465, ENSP00000452328, ENSP00000216274, ENST00000554756

PRO

Q9Y572

Pharos - Targets

Q9Y572

HMDB Protein

HMDBP01148

PDB

7MX3, 7MON, 5V7Z, 7DA4, 5ZCK, 7DAC

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13546 RIPK1	20	K48polyUb-RIPK1 [cytosol] (R-HSA-6783308) PolyUb-RIPK1 [cytosol] (R-HSA-6783197) RIPK1 D324N [cytosol] (R-HSA-9693930) RIPK1 D324Y [cytosol] (R-HSA-9693931) RIPK1 D324V [cytosol] (R-HSA-9693927) RIPK1 D324H [cytosol] (R-HSA-9693922) RIPK1 [plasma membrane] (R-HSA-937073) K48polyUb-K571,K604,K627-RIPK1 [cytosol] (R-HSA-9796639) K63,Met1polyUb-p-S25-RIPK1 [cytosol] (R-HSA-9818793) K63,M1polyUb-RIPK1 [cytosol] (R-HSA-9793681) RIPK1(1-324) [cytosol] (R-HSA-5212664) RIPK1(325-671) [cytosol] (R-HSA-5212671) polyUb-K377,K604,K634-RIPK1 [cytosol] (R-HSA-9818391) K63,M1polyUb, p-T189-RIPK1 [cytosol] (R-HSA-9817377) p-S320-RIPK1 [cytosol] (R-HSA-9815498) p-S357-RIPK1 [cytosol] (R-HSA-9819116) p-S166-RIPK1 [cytosol] (R-HSA-5218872) K63polyUb-RIPK1 [cytosol] (R-HSA-937021) RIPK1 [endosome membrane] (R-HSA-450326) RIPK1 [cytosol] (R-HSA-168651)	0.972	27
UniProt:Q9Y572 RIPK3	8	p-S199,227, K48pUb-363-RIPK3 [cytosol] (R-HSA-9686933) K33polyUb-K197,302,364-RIPK3 [cytosol] (R-HSA-9794180) OGlcNAc-T467-RIPK3 [cytosol] (R-HSA-9687819) RIPK3(329-518) [cytosol] (R-HSA-9686937) RIPK3(1-328) [cytosol] (R-HSA-9686917) RIPK3 [cytosol] (R-HSA-450328) p-S199,227-RIPK3 [cytosol] (R-HSA-5218873) Ub-K55,363-RIPK3 [cytosol] (R-HSA-9688825)	0.728	6
UniProt:Q8NB16 MLKL	3	K63PolyUb-K50,p-T357,S358-MLKL [cytosol] (R-HSA-9793468) p-T357,S358-MLKL [cytosol] (R-HSA-5218903) MLKL [cytosol] (R-HSA-5218901)	0.641	10
UniProt:Q13489 BIRC3	3	BIRC3 [cytosol] (R-HSA-50845) K48pUb-BIRC3 [cytosol] (R-HSA-5675478) K63polyUb-BIRC3 [cytosol] (R-HSA-5668478)	0.602	3
UniProt:Q13490 BIRC2	5	K63polyUb-BIRC2 [cytosol] (R-HSA-5668512) BIRC2(1-372) [cytosol] (R-HSA-202913) BIRC2(373-618) [cytosol] (R-HSA-202931) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2 [cytosol] (R-HSA-50847)	0.602	3
UniProt:Q14790 CASP8	8	CASP8(1-374) [cytosol] (R-HSA-3465404) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(1-479) [cytosol] (R-HSA-57031)	0.564	2
UniProt:J9TC74 J9TC74			0.463	3
UniProt:Q96HS1 PGAM5			0.462	3

Cite Us!