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p-T184,T187-MAP3K7 [endosome membrane]
Stable Identifier
R-HSA-450332
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endosome membrane
Synonyms
p-T184,187-TAK1
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TICAM1,TRAF6-dependent induction of TAK1 complex (Homo sapiens)
Activation of recruited TAK1 within the activated TLR3 complex (Homo sapiens)
viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:TAB2,TAB3:free polyUb: p-TAK1 [endosome membrane] (Homo sapiens)
p-T184,T187-MAP3K7 [endosome membrane] (Homo sapiens)
Phosphorylated TAK1 dissociates from the TLR3 receptor complex (Homo sapiens)
viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:TAB2,TAB3:free polyUb: p-TAK1 [endosome membrane] (Homo sapiens)
p-T184,T187-MAP3K7 [endosome membrane] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Homo sapiens)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane] (Homo sapiens)
p-T184,T187-MAP3K7 [endosome membrane] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Homo sapiens)
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane] (Homo sapiens)
p-T184,T187-MAP3K7 [endosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43318 MAP3K7
Gene Names
MAP3K7, TAK1
Chain
chain:1-606
Reference Genes
COSMIC (genes):MAP3K7 MAP3K7
dbSNP Gene:6885 MAP3K7
ENSEMBL:ENSG00000135341 MAP3K7
Participates
as a component of
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:TAB2,TAB3:free polyUb: p-TAK1 [endosome membrane] (Homo sapiens)
Other forms of this molecule
PolyUb-MAP3K7 [cytosol]
MAP3K7 [plasma membrane]
p-T187-MAP3K7 [cytosol]
K63polyUb-34,158-TAK1 [cytosol]
K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol]
p-MAP3K7 [cytosol]
MAP3K7 [endosome membrane]
MAP3K7 [cytosol]
p-T184,T187-MAP3K7 [cytosol]
Inferred To
phospho-MAP3K7 [endosome membrane]
(Canis familiaris)
phospho-p-T184,T187-MAP3K7 [endosome membrane]
(Bos taurus)
phospho-p-T184,T187-MAP3K7 [endosome membrane]
(Gallus gallus)
phospho-p-T184,T187-MAP3K7 [endosome membrane]
(Mus musculus)
phospho-p-T184,T187-MAP3K7 [endosome membrane]
(Rattus norvegicus)
phospho-p-T184,T187-MAP3K7 [endosome membrane]
(Sus scrofa)
phospho-p-T184,T187-MAP3K7 [endosome membrane]
(Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-threonine at 184
Coordinate
184
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at 187
Coordinate
187
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Interactors (20)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NYJ8 TAB2
4
TAB2 [cytosol]
(R-HSA-168117)
TAB2 [endosome membrane]
(R-HSA-450279)
TAB2 [plasma membrane]
(R-HSA-168116)
TAB2 [nucleoplasm]
(R-HSA-1253323)
0.91
8
UniProt:Q15750 TAB1
6
TAB1 [cytosol]
(R-HSA-167923)
TAB1 [endosome membrane]
(R-HSA-450238)
TAB1(1-444) [cytosol]
(R-HSA-9729751)
TAB1(1-132) [cytosol]
(R-HSA-9729698)
TAB1(133-504) [cytosol]
(R-HSA-9729724)
TAB1(445-504) [cytosol]
(R-HSA-9729691)
0.899
10
UniProt:Q8N5C8 TAB3
3
TAB3 [plasma membrane]
(R-HSA-446879)
TAB3 [endosome membrane]
(R-HSA-450247)
TAB3 [cytosol]
(R-HSA-450264)
0.773
5
UniProt:Q9UQF2 JIP1
0.723
11
UniProt:O14733 MAP2K7
4
MAP2K7(?-419) [cytosol]
(R-HSA-5211401)
MAP2K7(2-?) [cytosol]
(R-HSA-5211389)
MAP2K7 [cytosol]
(R-HSA-450276)
p-S271,T275-MAP2K7 [cytosol]
(R-HSA-450353)
0.674
3
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.669
4
UniProt:Q9Y4K3 TRAF6
8
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [endosome membrane]
(R-HSA-450272)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
0.669
3
UniProt:O14920 IKBKB
3
IKBKB [cytosol]
(R-HSA-168114)
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
0.657
6
UniProt:P0CG48 UBC
20
UBC(381-456) [endocytic vesicle membrane]
(R-HSA-939218)
UBC(533-608) [endocytic vesicle membrane]
(R-HSA-939220)
UBC(609-684) [endocytic vesicle membrane]
(R-HSA-939223)
UBC(457-532) [endocytic vesicle membrane]
(R-HSA-939195)
UBC(153-228) [endocytic vesicle membrane]
(R-HSA-939194)
UBC(305-380) [endocytic vesicle membrane]
(R-HSA-939228)
UBC(229-304) [endocytic vesicle membrane]
(R-HSA-939177)
UBC(77-152) [endocytic vesicle membrane]
(R-HSA-939210)
UBC(1-76) [endocytic vesicle membrane]
(R-HSA-939245)
Ub-565-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783166)
Ub-337-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783121)
Ub-185-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783154)
Ub-261-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783028)
Ub-413-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783061)
Ub-109-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783158)
Ub-641-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783182)
Ub-33-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783073)
Ub-489-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783078)
Ub-291-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783193)
Ub-595-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783130)
0.656
4
UniProt:O15111 CHUK
4
CHUK [cytosol]
(R-HSA-168104)
p-S176,S180-CHUK [cytosol]
(R-HSA-177667)
p-T23-CHUK [cytosol]
(R-HSA-198615)
p-Y187,Y198-CHUK [cytosol]
(R-HSA-9861501)
0.65
3
UniProt:B5Z6S0 B5Z6S0
0.602
4
UniProt:O00743 PPP6C
2
PPP6C [cytosol]
(R-HSA-5685719)
PPP6C [nucleoplasm]
(R-HSA-9686576)
0.602
4
UniProt:Q9UBE8 NLK
3
NLK [cytosol]
(R-HSA-4411330)
p-T298-NLK [cytosol]
(R-HSA-4411398)
p-T298-NLK [nucleoplasm]
(R-HSA-4411376)
0.569
3
UniProt:P40763 STAT3
12
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-STAT3 [cytosol]
(R-HSA-8982823)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
0.558
4
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-8S-N [cytosol]
(R-COV-9729335)
p-S188,206-N [cytosol]
(R-COV-9729324)
N [cytosol]
(R-COV-9694300)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
0.556
4
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.527
2
UniProt:Q96PV0 SYNGAP1
1
SYNGAP1 [cytosol]
(R-HSA-5658217)
0.527
3
UniProt:Q13451 FKBP5
2
FKBP5 [nucleoplasm]
(R-HSA-8939165)
FKBP5 [cytosol]
(R-HSA-5618096)
0.527
2
UniProt:Q9UKE5 TNIK
1
TNIK [cytosol]
(R-HSA-3214889)
0.499
3
UniProt:P15311 EZR
3
p-Y146,Y354-EZR [cytosol]
(R-HSA-374572)
p-T567-EZR [cytosol]
(R-HSA-374559)
EZR [cytosol]
(R-HSA-9020826)
0.483
2
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