Reactome | p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta

p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta

Stable Identifier

R-HSA-450394

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta

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Phosphorylated tristetraproline (TTP) binds 14-3-3, which inhibits the ability of TTP to destabilize RNA. Thus RNAs bound by TTP become stabilized. The binding of 14-3-3 causes TTP to be excluded from stress granules.

Literature References

PubMed ID	Title	Journal	Year
18481987	Control of mRNA decay by phosphorylation of tristetraprolin Stoecklin, G, Sandler, H	Biochem Soc Trans	2008
15014438	MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay Stubbs, T, Stoecklin, G, Blackwell, TK, Kedersha, N, Rigby, WF, Anderson, P, Wax, S	EMBO J	2004
14688255	MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding Shabanowitz, J, Sturgill, TW, Hunt, DF, Schroeder, MJ, Chrestensen, CA, Pelo, JW, Worthington, MT	J Biol Chem	2004
15944294	Structure/function analysis of tristetraprolin (TTP): p38 stress-activated protein kinase and lipopolysaccharide stimulation do not alter TTP function Bloch, DB, Collins, J, Roy, K, Brooks, SA, Rigby, S, Rigby, WF, Connolly, JE	J Immunol	2005