Reactome | ZFP36 (TTP) recruits RNA degradation activities

ZFP36 (TTP) recruits RNA degradation activities

Stable Identifier

R-HSA-450431

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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ZFP36 (TTP) recruits RNA degradation activities

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TTP interacts directly with exonucleases (XRN1 and the exosome) and decapping enzymes (DCP1a and DCP2) which hydrolyze the mRNA bound by TTP. TTP also recruits PARN deadenylase, however a direct interaction between TTP and PARN has not been demonstrated.

Literature References

PubMed ID	Title	Journal	Year
11719186	AU binding proteins recruit the exosome to degrade ARE-containing mRNAs Karin, M, Stoecklin, G, Ong, SE, Gherzi, R, Mann, M, Chan, EL, Chen, CY, Raijmakers, R, Moroni, C, Pruijn, GJ	Cell	2001
12748283	Tristetraprolin and its family members can promote the cell-free deadenylation of AU-rich element-containing mRNAs by poly(A) ribonuclease Kennington, EA, Lai, WS, Blackshear, PJ	Mol Cell Biol	2003
17133347	Tristetraprolin recruits functional mRNA decay complexes to ARE sequences Williams, DA, Walsh, RJ, Hau, HH, Ogilvie, RL, Bohjanen, PR, Reilly, CS	J Cell Biochem	2007
15687258	Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1 Lykke-Andersen, J, Wagner, E	Genes Dev	2005