Reactome | Regulation of mRNA stability by proteins that bind AU-rich elements

Regulation of mRNA stability by proteins that bind AU-rich elements

Stable Identifier

R-HSA-450531

Type

Pathway

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

ReviewStatus

5/5

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Regulation of mRNA stability by proteins that bind AU-rich elements

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RNA elements rich in adenine and uracil residues (AU-rich elements) bind specific proteins which either target the RNA for degradation or, more rarely, stabilize the RNA. The activity of the AU-element binding proteins is regulated, usually by phosphorylation but also by subcellular localization.

Literature References

PubMed ID	Title	Journal	Year
16391004	AU-rich elements and associated factors: are there unifying principles? Barreau, C, Paillard, L, Osborne, HB	Nucleic Acids Res	2005
15460540	AU-rich elements and the control of gene expression through regulated mRNA stability LaMarre, J, Gingerich, TJ, Feige, JJ	Anim Health Res Rev	2004
12704645	Post-transcriptional regulation of gene expression by degradation of messenger RNAs Ceriani, MC, Bevilacqua, A, Capaccioli, S, Nicolin, A	J Cell Physiol	2003
12440953	AU-rich element-mediated translational control: complexity and multiple activities of trans-activating factors Kruys, V, Zhang, T, Huez, G, Gueydan, C	Biochem Soc Trans	2002