PKCdelta phosphorylates HuR

Stable Identifier
R-HSA-450533
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PKCdelta phosphorylates HuR
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Protein kinase C delta (PKCdelta) phosphorylates HuR (ELAVL1) at serine 221 and serine 318.
Literature References
PubMed ID Title Journal Year
18285462 Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA

Pfeilschifter, J, Müller, R, Doller, A, Huwiler, A, Akool, el-S, Eberhardt, W, Radeke, HH

Mol Cell Biol 2008
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein kinase C activity of PRKCD(1-676) [nucleoplasm]

Physical Entity
PRKCD(1-676) [nucleoplasm] (Homo sapiens)
Activity
protein kinase C activity (GO:0004697)
Orthologous Events
PKCdelta phosphorylates HuR (Bos taurus)
PKCdelta phosphorylates HuR (Canis familiaris)
PKCdelta phosphorylates HuR (Drosophila melanogaster)
PKCdelta phosphorylates HuR (Gallus gallus)
PKCdelta phosphorylates HuR (Mus musculus)
PKCdelta phosphorylates HuR (Rattus norvegicus)
PKCdelta phosphorylates HuR (Sus scrofa)
PKCdelta phosphorylates HuR (Xenopus tropicalis)
Authored
May, B  (2009-12-29)
Reviewed
Wilusz, J  (2010-06-29)
Created
May, B  (2009-12-17)
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