PKCalpha phosphorylates HuR

Stable Identifier
R-HSA-450550
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PKCalpha phosphorylates HuR
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Protein kinase C alpha (PKCalpha) phosphorylates HuR (ELAVL1) on serine221 and serine 158.
Literature References
PubMed ID Title Journal Year
17392515 Protein kinase C alpha-dependent phosphorylation of the mRNA-stabilizing factor HuR: implications for posttranscriptional regulation of cyclooxygenase-2

Pfeilschifter, J, Müller, R, Doller, A, Huwiler, A, Eberhardt, W, Radeke, HH

Mol Biol Cell 2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein kinase C activity of PRKCA [nucleoplasm]

Physical Entity
PRKCA [nucleoplasm] (Homo sapiens)
Activity
protein kinase C activity (GO:0004697)
Orthologous Events
PKCalpha phosphorylates HuR (Canis familiaris)
PKCalpha phosphorylates HuR (Drosophila melanogaster)
PKCalpha phosphorylates HuR (Gallus gallus)
PKCalpha phosphorylates HuR (Mus musculus)
PKCalpha phosphorylates HuR (Rattus norvegicus)
PKCalpha phosphorylates HuR (Sus scrofa)
Authored
May, B  (2009-12-29)
Reviewed
Wilusz, J  (2010-06-29)
Created
May, B  (2009-12-17)
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