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Ub-HNRNPD-4 [cytosol]
Stable Identifier
R-HSA-451232
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Ubiquinated AUF1 isoform p37, Heterogeneous nuclear ribonucleoprotein D0, HNRNPD, HNRPD_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
Regulation of mRNA stability by proteins that bind AU-rich elements (Homo sapiens)
AUF1 (hnRNP D0) binds and destabilizes mRNA (Homo sapiens)
AUF1 (hnRNP D0) is ubiquitinylated (Homo sapiens)
Ubiquitinated AUF1 Tetramer: Destabilized mRNA Complex [cytosol] (Homo sapiens)
Ubiquitinated AUF1 Tetramer [cytosol] (Homo sapiens)
Ubiquitinated AUF1 (isoform p37 or p40) [cytosol] (Homo sapiens)
Ub-HNRNPD-4 [cytosol] (Homo sapiens)
AUF1:mRNA complex is destroyed (Homo sapiens)
Ubiquitinated AUF1 Tetramer: Destabilized mRNA Complex [cytosol] (Homo sapiens)
Ubiquitinated AUF1 Tetramer [cytosol] (Homo sapiens)
Ubiquitinated AUF1 (isoform p37 or p40) [cytosol] (Homo sapiens)
Ub-HNRNPD-4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14103-4 HNRNPD
Gene Names
HNRNPD, AUF1, HNRPD
Other Identifiers
11728678_s_at
11729145_x_at
11729146_a_at
11749303_s_at
11749304_x_at
11760952_x_at
11761589_x_at
16657157
16657159
16657161
16657163
16657165
16657167
16657169
16657171
16657173
16657175
16657197
16657201
16657203
16977340
18670045
18670046
18670047
18670048
18670049
18670050
18670051
18670052
18670053
18670054
18670055
18670056
18670057
18670058
18670059
18670060
18670061
18670062
18670063
200073_PM_s_at
200073_s_at
209330_PM_s_at
209330_s_at
213359_PM_at
213359_at
221480_PM_at
221480_at
221481_PM_x_at
221481_x_at
229129_PM_at
229129_at
2775464
2775465
2775466
2775467
2775468
2775469
2775470
2775471
2775472
2775473
2775474
2775475
2775476
2775477
2775478
2775479
2775480
2775481
2775482
2775483
2775484
2775485
2775486
2775487
2775488
2775496
2775497
2775498
2775499
2775500
2775501
2775502
2775503
2775546
2775577
3184
38016_at
3979400
55964_at
64726_at
7892568
7892832
7892838
7893015
7893393
7893649
7894239
7894258
7894305
7894806
7894845
7894877
7895214
7895247
7895373
7895521
7895590
7896175
7896553
8101324
A_23_P58353
A_24_P123245
A_24_P226037
GE58851
GO:0000785
GO:0001889
GO:0003676
GO:0003677
GO:0003680
GO:0003682
GO:0003723
GO:0003729
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006355
GO:0006396
GO:0006401
GO:0010468
GO:0010628
GO:0010629
GO:0014069
GO:0021549
GO:0032212
GO:0032355
GO:0035925
GO:0042162
GO:0042752
GO:0042826
GO:0043226
GO:0043488
GO:0045202
GO:0045727
GO:0045893
GO:0045944
GO:0048511
GO:0048856
GO:0051592
GO:0051602
GO:0061158
GO:0070934
GO:0071230
GO:0071392
GO:0071732
GO:0097167
GO:0098978
GO:0106002
GO:1900152
GO:1901355
GO:1904355
GO:1904383
GO:1904586
GO:1990828
GO:1990904
GO:2000767
HMNXSV003054269
Hs.303627.1.S2_3p_at
Hs.303627.5.A1_3p_at
Hs.61795.0.A1_3p_at
ILMN_1751368
ILMN_2321451
M94630_at
PH_hs_0020776
PH_hs_0039701
TC04001332.hg
g181913_3p_a_at
Participates
as a member of
Ubiquitinated AUF1 (isoform p37 or p40) [cytosol] (Homo sapiens)
Other forms of this molecule
HNRNPD-4 [cytosol]
Inferred To
Homologues of Ub-HNRNPD-4 [cytosol]
(Plasmodium falciparum)
Ub-HNRNPD-4 [cytosol]
(Dictyostelium discoideum)
Ub-HNRNPD-4 [cytosol]
(Gallus gallus)
Ub-HNRNPD-4 [cytosol]
(Plasmodium falciparum)
Hnrnpd [cytosol]
(Mus musculus)
Hnrnpd [cytosol]
(Rattus norvegicus)
sqd [cytosol]
(Drosophila melanogaster)
HNRNPD [cytosol]
(Bos taurus)
HNRNPD [cytosol]
(Canis familiaris)
HNRNPD [cytosol]
(Sus scrofa)
hnrnpd [cytosol]
(Danio rerio)
hnrnpd [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position
Modification
K48polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
OpenTargets
ENSG00000138668
ENSEMBL
ENSP00000421952
,
ENSG00000138668
,
ENST00000313899
,
ENST00000507010
,
ENSP00000313199
,
ENST00000352301
,
ENSP00000515597
,
ENSP00000305860
,
ENST00000503822
,
ENST00000703971
,
ENSP00000313327
,
ENST00000353341
,
ENSP00000422615
HPA
ENSG00000138668-HNRNPD
GeneCards
HNRNPD
PRO
Q14103
Pharos - Targets
Q14103
GlyGen
Q14103
PDB
1HD0
,
1WTB
,
1HD1
,
2Z5N
,
1X0F
,
1IQT
,
5IM0
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q00839 HNRNPU
1
HNRNPU [nucleoplasm]
(R-HSA-71953)
0.752
5
UniProt:P22626 HNRNPA2B1
2
HNRNPA2B1 [nucleoplasm]
(R-HSA-71929)
HNRNPA2B1 [extracellular exosome]
(R-HSA-8950304)
0.669
4
UniProt:O14979 HNRNPDL
1
HNRNPDL [cytosol]
(R-HSA-8950323)
0.564
2
UniProt:P07910 HNRNPC
3
HNRNPC [nucleoplasm]
(R-HSA-71933)
SUMO1-K250-HNRNPC [nucleoplasm]
(R-HSA-4570543)
HNRNPC [cytosol]
(R-HSA-9715136)
0.547
3
UniProt:P61978 HNRNPK
2
HNRNPK [nucleoplasm]
(R-HSA-71945)
polySUMO2-K422-HNRNPK [nucleoplasm]
(R-HSA-4570532)
0.547
2
UniProt:Q9NZI8 IGF2BP1
1
IGF2BP1 [cytosol]
(R-HSA-428366)
0.527
2
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.527
5
UniProt:Q9BYZ2 LDHAL6B
1
LDHAL6B [mitochondrial matrix]
(R-HSA-6807613)
0.524
2
UniProt:Q12906 ILF3
3
ILF3 [nucleoplasm]
(R-HSA-9760401)
ILF3 [cytosol]
(R-HSA-450564)
p-T188,T315-ILF3 [cytosol]
(R-HSA-9836381)
0.483
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
6
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