Activation of JNK by DSCAM

Stable Identifier
R-HSA-451347
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Activation of JNK by DSCAM
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DSCAM can stimulate the activation of JNK, one of the downstream events induced by activated PAK1. From the experiment using various dominant negative mutants it was suggested that PAK1 and MKK4 play a role in JNK activation.

Literature References
PubMed ID Title Journal Year
15169762 The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak

Guan, KL, Li, W

J Biol Chem 2004
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of DSCAM:p-S144-PAK1:RAC1:GTP [plasma membrane]

Physical Entity
DSCAM:p-S144-PAK1:RAC1:GTP [plasma membrane] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Activation of JNK by DSCAM (Bos taurus)
Activation of JNK by DSCAM (Canis familiaris)
Activation of JNK by DSCAM (Danio rerio)
Activation of JNK by DSCAM (Drosophila melanogaster)
Activation of JNK by DSCAM (Mus musculus)
Activation of JNK by DSCAM (Rattus norvegicus)
Activation of JNK by DSCAM (Sus scrofa)
Authored
Garapati, P V  (2010-01-05)
Reviewed
Clemens, JC  (2010-08-10)
Created
Garapati, P V  (2010-01-05)
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