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Interaction of nephrin with adherens junction-associated proteins
Stable Identifier
R-HSA-451403
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Cell-Cell communication (Homo sapiens)
Nephrin family interactions (Homo sapiens)
Interaction of nephrin with adherens junction-associated proteins (Homo sapiens)
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The nephrin-slit diaphragm protein complex contains a group of scaffolding proteins that function to connect junctional membrane proteins to the actin cytoskeleton and signaling cascades. By mass spectrometry four of the proteins identified, alphaII spectrin, betaII spectrin, alpha-actinin, and IQGAP1, represent adherens junction-associated proteins, and two, MAGI-2/S-SCAM and CASK, represent MAGUK family scaffolding proteins that associate with Ig superfamily proteins. The presence of these proteins in slit diaphragms and their association with nephrin suggests that they may form a scaffolding protein complex in the podocyte slit diaphragm and thus contribute to the regulation of ultrafiltration by binding slit membrane proteins and establishing their cytosolic connections.
Participants
Input
adherens junction-associated proteins [cytosol]
(Homo sapiens)
NPHS1 dimer:KIRREL [plasma membrane]
(Homo sapiens)
Output
Nephrin dimer:adherins junction-associated proteins [plasma membrane]
(Homo sapiens)
Participates
as an event of
Nephrin family interactions (Homo sapiens)
Inferred From
Interaction of nephrin with adherens junction-associated proteins (Rattus norvegicus)
Authored
Garapati, P V (2008-02-26)
de Bono, B (2008-02-26)
Reviewed
Grahammer, Florian (2010-05-20)
Huber, TB (2010-05-20)
Created
Garapati, P V (2010-01-05)
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