K63polyUb-hp-IRAK1 [cytosol]

Stable Identifier
R-HSA-451565
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Icon
K63polyUb-hp-IRAK1 [cytosol] icon
K63polyUb-hp-IRAK1 [cytosol] icon
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
18347055 Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation

Conze, DB, Landstrom, A, Ashwell, JD, Thomas, JA, Wu, CJ

Mol Cell Biol 2008
External Reference Information
External Reference
UniProt:P51617 IRAK1
Gene Names
IRAK1, IRAK
Chain
chain:1-712
Reference Genes
BioGPS Gene:3654 IRAK1
COSMIC (genes):IRAK1 IRAK1
CTD Gene:3654 IRAK1
dbSNP Gene:3654 IRAK1
ENSEMBL:ENSG00000184216 IRAK1
HGNC:6112 IRAK1
KEGG:hsa:3654 IRAK1
Monarch:3654 IRAK1
NCBI Gene:3654 IRAK1
OMIM:300283 IRAK1
UCSC:P51617 IRAK1
Reference Transcript
Participates
as an output of
as a component of
as an input of
Other forms of this molecule
IRAK1 [cytosol]
p-2S,S376,T,T209,T387-IRAK1 [cytosol]
p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]
p-T209,T387-IRAK1 [plasma membrane]
p-T209-IRAK1 [plasma membrane]
IRAK1 [plasma membrane]
p-2S,S376,T,T209,T387-IRAK1 [endosome membrane]
IRAK1 [endosome membrane]
p-T209,T387-IRAK1 [endosome membrane]
p-T209-IRAK1 [endosome membrane]
p-S,T-IRAK1 [cytosol]
K63polyUb-hp-IRAK1 [endosome membrane]
p-S376,T387-IRAK1 [cytosol]
Inferred To
Homologues of K63polyUb-hp-IRAK1 [cytosol] (Saccharomyces cerevisiae)
phospho-IRAK1 [cytosol] (Canis familiaris)
Ghost homologue of K63polyUb-hp-IRAK1 [cytosol] (Danio rerio)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Bos taurus)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Caenorhabditis elegans)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Dictyostelium discoideum)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Drosophila melanogaster)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Mus musculus)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Rattus norvegicus)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Saccharomyces cerevisiae)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Schizosaccharomyces pombe)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Sus scrofa)
Modified Residues
Name
O-phospho-L-threonine at 209
Coordinate
209
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 376
Coordinate
376
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 387
Coordinate
387
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at unknown position
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 134
Coordinate
134
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 160
Coordinate
160
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
Guide to Pharmacology - Targets
OpenTargets
ENSEMBL
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
GlyGen
PDB
ZINC - Investigational
GeneCards
HPA
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (22)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q9Y4K3 TRAF6  8 0.77 4
 UniProt:Q9HAT8 PELI2  2 0.743 4
 UniProt:Q96FA3 PELI1  2 0.734 4
 UniProt:Q99836 MYD88  8 0.723 4
 UniProt:Q13526 PIN1  2 0.645 10
 UniProt:P58753 TIRAP  2 0.623 3
 UniProt:Q8N2H9-2 PELI3      0.589 2
 UniProt:O43187 IRAK2  6 0.564 3
 UniProt:Q9Y616 IRAK3  1 0.564 3
 UniProt:Q9NWZ3 IRAK4  9 0.547 2
 UniProt:Q5D1E7  1 0.544 3
 UniProt:P50402 EMD  4 0.527 2
 UniProt:Q13451 FKBP5  2 0.527 2
 UniProt:Q9UNE7 STUB1  1 0.527 2
 UniProt:P31689 DNAJA1  2 0.527 2
 UniProt:Q96EY1 DNJA3      0.527 2
 UniProt:O60884 DNAJA2  1 0.527 2
 UniProt:O15027 SEC16A  1 0.527 2
 UniProt:Q92985 IRF7  5 0.499 2
 UniProt:Q15306 IRF4  2 0.499 2
 UniProt:Q8VCW4  2 0.499 2
 UniProt:Q86WV6 STING1  5 0.499 2
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