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p-S927,S932-NFKB1(1-968) [cytosol]
Stable Identifier
R-HSA-451611
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-S927,S932-NFKB1, p-NFkB p105, Nuclear factor NF-kappa-B p105 subunit
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
p-S927,S932-NFKB1(1-968):MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
p-S927,S932-NFKB1(1-968):MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
p-S927,S932-NFKB1(1-968):MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
p-S927,S932-NFKB1(1-968):MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
p-S927,S932-NFKB1(1-968):MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
p-S927,S932-NFKB1(1-968):MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
p-S927,S932-NFKB1(1-968):MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
p-S927,S932-NFKB1(1-968):MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
p-S927,S932-NFKB1(1-968):MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
p-S927,S932-NFKB1(1-968):MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
p-S927,S932-NFKB1(1-968):MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P19838 NFKB1
Gene Names
NFKB1
Chain
chain:1-968, chain:1-433
Reference Genes
BioGPS Gene:4790 NFKB1
COSMIC (genes):NFKB1 NFKB1
CTD Gene:4790 NFKB1
dbSNP Gene:4790 NFKB1
ENSEMBL:ENSG00000109320 NFKB1
ENSEMBL_homo_sapiens_GENE:ENSG00000109320.14 NFKB1
HGNC:7794 NFKB1
KEGG Gene (Homo sapiens):4790 NFKB1
Monarch:4790 NFKB1
NCBI Gene:4790 NFKB1
OMIM:164011 NFKB1
UCSC:P19838 NFKB1
Reference Transcript
RefSeq:NM_001319226.1 NFKB1
RefSeq:NM_001165412.1 NFKB1
RefSeq:NM_003998.3 NFKB1
Other Identifiers
11717542_a_at
1377_at
1378_g_at
16969300
209239_PM_at
209239_at
2737731
2737732
2737737
2737740
2737743
2737745
2737753
2737756
2737759
2737762
2737763
2737765
2737770
2737771
2737772
2737773
2737775
2737776
2737781
2737783
2737784
2737789
2737790
2737791
2737793
2737796
2737797
38438_at
4790
8096635
A_14_P115699
A_23_P30024
GE57992
GO:0000122
GO:0000165
GO:0000785
GO:0000976
GO:0000977
GO:0000978
GO:0000981
GO:0001227
GO:0001228
GO:0001818
GO:0002376
GO:0003677
GO:0003682
GO:0003700
GO:0003712
GO:0005515
GO:0005576
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005739
GO:0005829
GO:0005975
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0006629
GO:0006766
GO:0006915
GO:0006954
GO:0007165
GO:0007249
GO:0007254
GO:0008092
GO:0010467
GO:0010468
GO:0010629
GO:0010744
GO:0010884
GO:0010956
GO:0010957
GO:0012501
GO:0023052
GO:0030154
GO:0031410
GO:0032375
GO:0032695
GO:0033256
GO:0034097
GO:0034774
GO:0035525
GO:0035580
GO:0035994
GO:0038061
GO:0042802
GO:0042805
GO:0043066
GO:0043226
GO:0043565
GO:0045087
GO:0045892
GO:0045893
GO:0045944
GO:0048856
GO:0050728
GO:0050853
GO:0051248
GO:0060056
GO:0060261
GO:0071222
GO:0071260
GO:0071316
GO:0071347
GO:0071354
GO:0071356
GO:0071359
GO:0090263
GO:0097398
GO:0098542
GO:0098586
GO:0140110
GO:0140367
GO:1900127
GO:1901135
GO:1904385
GO:2000630
HMNXSV003038926
ILMN_1714965
M58603_at
PH_hs_0022751
TC04000526.hg
g189179_3p_at
Participates
as a component of
p-S927,S932-NFKB1(1-968):MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
Other forms of this molecule
NFKB1(1-968) [specific granule lumen]
NFKB1(1-968) [extracellular region]
NFKB1(1-968) [secretory granule lumen]
NFKB1(1-433) [cytosol]
NFKB1(1-433) [nucleoplasm]
NFKB1(1-968) [cytosol]
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
Inferred To
phospho-NFKB1 [cytosol]
(Bos taurus)
phospho-NFKB1 [cytosol]
(Canis familiaris)
phospho-NFKB1 [cytosol]
(Gallus gallus)
phospho-NFKB1 [cytosol]
(Sus scrofa)
phospho-nfkb1 [cytosol]
(Xenopus tropicalis)
Ghost homologue of p-S927,S932-NFKB1(1-968) [cytosol]
(Rattus norvegicus)
Ghost homologue of p-S927,S932-NFKB1(1-968) [cytosol]
(Saccharomyces cerevisiae)
phospho-Nfkb1 [cytosol]
(Mus musculus)
Modified Residues
Name
O-phospho-L-serine at 927
Coordinate
927
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 932
Coordinate
932
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001158884.1
,
NP_001306155.1
,
NP_003989.2
Guide to Pharmacology - Targets
3281
OpenTargets
ENSG00000109320
ZINC - Substances
NFKB1_HUMAN
ZINC - Biogenic
NFKB1_HUMAN
ZINC target
P19838
PRO
P19838
PDB
1MDJ
,
8TQD
,
7LEQ
,
7LF4
,
7LFC
,
1SVC
,
2O61
,
7RG5
,
1NFI
,
7LET
,
1MDI
,
1MDK
,
2DBF
,
3GUT
,
7RG4
ZINC - Metabolites
NFKB1_HUMAN
HPA
ENSG00000109320-NFKB1
GeneCards
P19838
Ensembl
ENSP00000423877
,
ENST00000394820
,
ENST00000226574
,
ENSP00000378297
,
ENSP00000226574
,
ENSG00000109320
,
ENST00000505458
,
ENST00000509165
,
ENSP00000424790
Pharos - Targets
P19838
Orphanet
23358
ZINC - Predictions - Purchasable
NFKB1_HUMAN
HMDB Protein
HMDBP02145
Interactors (36)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P25963 NFKBIA
9
PolyUb-NFKBIA [cytosol]
(R-HSA-6782960)
NFKBIA [cytosol]
(R-HSA-168151)
p-S32,S36-NFKBIA [cytosol]
(R-HSA-177677)
Ub-K21,22-p-S32,S36-NFKBIA [cytosol]
(R-HSA-1168581)
NFKBIA [nucleoplasm]
(R-HSA-4656929)
monoSUMO1-K21-NFKBIA [nucleoplasm]
(R-HSA-4656935)
NFKBIA S32I [cytosol]
(R-HSA-5228846)
NFKBIA F2_M37del [cytosol]
(R-HSA-9630119)
NFKBIA M37K [cytosol]
(R-HSA-5228805)
0.933
11
UniProt:P41279 MAP3K8
3
p-S400-MAP3K8 [cytosol]
(R-HSA-389738)
MAP3K8 [cytosol]
(R-HSA-389388)
p-S400,T290-MAP3K8 [cytosol]
(R-HSA-5684259)
0.927
14
UniProt:Q04206 RELA
7
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
p-S536-RELA [nucleoplasm]
(R-HSA-9861499)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
RELA [cytosol]
(R-HSA-168172)
RELA [nucleoplasm]
(R-HSA-177676)
0.924
16
UniProt:Q01201 RELB
2
RELB [nucleoplasm]
(R-HSA-5607656)
RELB [cytosol]
(R-HSA-5607652)
0.865
8
UniProt:Q00653 NFKB2
6
monoSUMO1-K90,K298,K689,K863-NFKB2(1-900) [cytosol]
(R-HSA-4755500)
NFKB2(1-900) [cytosol]
(R-HSA-2677931)
K48-polyUb-p-7S-p100 [cytosol]
(R-HSA-5607636)
p-7S-p100 [cytosol]
(R-HSA-5607629)
NFKB2(1-454) [cytosol]
(R-HSA-168144)
NFKB2(1-454) [nucleoplasm]
(R-HSA-177674)
0.823
10
UniProt:Q04864 REL
2
REL [cytosol]
(R-HSA-1168579)
REL [nucleoplasm]
(R-HSA-1168585)
0.816
10
UniProt:O15111 CHUK
4
CHUK [cytosol]
(R-HSA-168104)
p-S176,S180-CHUK [cytosol]
(R-HSA-177667)
p-T23-CHUK [cytosol]
(R-HSA-198615)
p-Y187,Y198-CHUK [cytosol]
(R-HSA-9861501)
0.779
4
UniProt:O14920 IKBKB
3
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
IKBKB [cytosol]
(R-HSA-168114)
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
0.773
4
UniProt:P19838 NFKB1
8
NFKB1(1-968) [specific granule lumen]
(R-HSA-6799557)
NFKB1(1-968) [extracellular region]
(R-HSA-6806304)
NFKB1(1-968) [secretory granule lumen]
(R-HSA-6801004)
NFKB1(1-433) [cytosol]
(R-HSA-168168)
NFKB1(1-433) [nucleoplasm]
(R-HSA-177655)
NFKB1(1-968) [cytosol]
(R-HSA-451607)
p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451611)
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451619)
0.764
7
UniProt:Q15653 NFKBIB
3
p-S19,S23-Ub-NFKBIB [cytosol]
(R-HSA-1168571)
p-S19,S23-NFKBIB [cytosol]
(R-HSA-177670)
NFKBIB [cytosol]
(R-HSA-168132)
0.763
6
UniProt:Q9NWT6 HIF1AN
1
HIF1AN [cytosol]
(R-HSA-1234154)
0.744
7
UniProt:Q15025 TNIP1
1
TNIP1 [cytosol]
(R-HSA-5690853)
0.725
6
UniProt:O60271 SPAG9
1
SPAG9 [cytosol]
(R-HSA-375975)
0.695
4
UniProt:P35606 COPB2
4
COPB2 [endoplasmic reticulum membrane]
(R-HSA-6810957)
COPB2 [Golgi membrane]
(R-HSA-6808739)
COPB2 [transport vesicle]
(R-HSA-6808741)
COPB2 [cytosol]
(R-HSA-199972)
0.689
5
UniProt:Q8NFZ5 TNIP2
1
TNIP2 [cytosol]
(R-HSA-451661)
0.689
7
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.646
5
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.646
3
IntAct:EBI-9870239 IKK
0.623
2
UniProt:P23396 RPS3
2
RPS3 [nucleoplasm]
(R-HSA-6798714)
RPS3 [cytosol]
(R-HSA-72369)
0.623
5
UniProt:Q9Y6K9 IKBKG
12
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG [nucleoplasm]
(R-HSA-4755413)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
IKBKG [cytosol]
(R-HSA-168108)
0.615
3
UniProt:O00221 NFKBIE
3
NFKBIE [cytosol]
(R-HSA-1168580)
p-S157,S161-NFKBIE [cytosol]
(R-HSA-1168561)
p-S157,S161-Ub-NFKBIE [cytosol]
(R-HSA-1168563)
0.604
3
UniProt:Q9UKB1 FBXW11
1
FBXW11 [cytosol]
(R-HSA-976035)
0.597
5
UniProt:Q9Y297 BTRC
2
BTRC [cytosol]
(R-HSA-174237)
BTRC [nucleoplasm]
(R-HSA-3361753)
0.597
5
UniProt:Q92905 COPS5
2
COPS5 [nucleoplasm]
(R-HSA-5697019)
COPS5 [cytosol]
(R-HSA-416963)
0.547
2
UniProt:P14921 ETS1
2
ETS1 [nucleoplasm]
(R-HSA-1629809)
p-T38-ETS1 [nucleoplasm]
(R-HSA-3132720)
0.536
2
UniProt:Q13619 CUL4A
2
CUL4A [nucleoplasm]
(R-HSA-976006)
G76-NEDD8-K705-CUL4A [nucleoplasm]
(R-HSA-8952514)
0.527
2
UniProt:O14965 AURKA
6
SUMO1-K258-AURKA [cytosol]
(R-HSA-4655367)
p-T288-AURKA [nucleoplasm]
(R-HSA-6805089)
PolyUb-AURKA [cytosol]
(R-HSA-8854040)
AURKA [nucleoplasm]
(R-HSA-4655443)
AURKA [cytosol]
(R-HSA-174254)
p-T288-AURKA [cytosol]
(R-HSA-2574832)
0.527
3
UniProt:P10226 PAP
0.524
4
UniProt:Q8IV08 PLD3
2
PLD3 [endoplasmic reticulum membrane]
(R-HSA-1498798)
PLD3 [plasma membrane]
(R-HSA-2029042)
0.524
2
UniProt:Q8IZL8 PELP1
1
PELP1 [nucleoplasm]
(R-HSA-3826531)
0.524
2
UniProt:Q14690 PDCD11
1
PDCD11 [nucleoplasm]
(R-HSA-6790646)
0.508
2
UniProt:Q92887 ABCC2
5
ABCC2 R768W [plasma membrane]
(R-HSA-5679033)
ABCC2 R1066* [plasma membrane]
(R-HSA-5679021)
ABCC2 R1150H [plasma membrane]
(R-HSA-5679024)
ABCC2 I1173F [plasma membrane]
(R-HSA-5679030)
ABCC2 [plasma membrane]
(R-HSA-375571)
0.508
3
UniProt:P34931 HSPA1L
2
HSPA1L [cytosol]
(R-HSA-3371410)
HSPA1L [nucleoplasm]
(R-HSA-5082367)
0.483
3
UniProt:Q9BQI6 SLF1
0.483
2
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.483
3
UniProt:P08563-PRO_0000041302
0.463
2
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