Reactome | Heterodimerization of nephrin and KIRREL2, KIRREL3

Heterodimerization of nephrin and KIRREL2, KIRREL3

Stable Identifier

R-HSA-451757

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Heterodimerization of nephrin and KIRREL2, KIRREL3

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NEPH2 and NEPH3 specifically interact with the extracellular domains of nephrin in the slit diaphragm of podocytes and potentially other tissues as well (eg. brain). The functional significance of these interactions is unknown.

Literature References

PubMed ID	Title	Journal	Year
20233749	A model organism approach: defining the role of Neph proteins as regulators of neuron and kidney morphogenesis Walz, G, Gödel, M, Martin, K, Kramer-Zucker, A, Noutsou, F, Wanner, N, Ritter, A, Pagel, P, Huber, TB, Müller, A, Slanchev, K, Baumeister, R, Hartleben, B, Fu, X, Neumann-Haefelin, E	Hum Mol Genet	2010
15843475	NEPH2 is located at the glomerular slit diaphragm, interacts with nephrin and is cleaved from podocytes by metalloproteinases Walz, G, Petraschka, D, Kretz, O, Benzing, T, Zentgraf, H, Gerke, P, Sellin, L	J Am Soc Nephrol	2005