p85 associates with both p-Nephrin and CD2AP

Stable Identifier
R-HSA-451758
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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p85 associates with both p-Nephrin and CD2AP
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The regulatory p85 subunit of PI3K recognizes and binds to both phosphorylated nephrin and its binding partner, CD2AP. By mutation analysis, nephrin Y1158 was shown to be necessary for the interaction. This interaction allows the catalytic subunit p110 to act on phospholipids of the inner leaflet of the cell membrane. This leads to downstream phosphorylation and inactivation of the apoptotic factor Bad via the serine-threonine kinase AKT.
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Inferred From
p85 associates with both p-Nephrin and CD2AP (Rattus norvegicus)
Authored
Garapati, P V  (2008-02-26)
de Bono, B  (2008-02-26)
Reviewed
Grahammer, Florian  (2010-05-20)
Huber, TB  (2010-05-20)
Created
Garapati, P V  (2010-01-11)
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