Reactome | IL2RG binds JAK3

IL2RG binds JAK3

Stable Identifier

R-HSA-451895

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Cytokine receptor common gamma subunit (IL2RG, IL-2 receptor gamma chain, Gc) associates with Tyrosine-protein kinase JAK3 (JAK3). The carboxyl-terminal region of IL2RG is important for this association (Miyazaki et al. 1994, Zhu et al. 1998, Russel et al. 2004, Chen et al.1997, Nelson et al.1994) as well as the FERM domain in JAK3 (Zhou et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
9553136	Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta Berry, JA, Zhu, MH, Russell, SM, Leonard, WJ	J Biol Chem	1998
7514277	Cytoplasmic domains of the interleukin-2 receptor beta and gamma chains mediate the signal for T-cell proliferation Lord, JD, Nelson, BH, Greenberg, PD	Nature	1994