Reactome | arginine + H2O => ornithine + urea [ARG2]

arginine + H2O => ornithine + urea [ARG2]

Stable Identifier

R-HSA-452036

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

ReviewStatus

5/5

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arginine + H2O => ornithine + urea [ARG2]

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Arginase 2 (ARG2) trimer catalyzes the hydrolysis of arginine to form urea and ornithine (Cama et al. 2003). ARG2 is localized to the mitochondrion (Gotoh ea 1996). The enzyme is expressed in many tissues in addition to liver and while its function appears to mitigate the effects of ARG1 deficiency on urea synthesis, its normal physiological roles have not been fully defined (Iyer et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
9686347	The human arginases and arginase deficiency Iyer, RK, Cederbaum, SD, Vockley, JG, Kern, RM, Jenkinson, CP, Grody, WW	J Inherit Metab Dis	1998
8898077	Molecular cloning of cDNA for nonhepatic mitochondrial arginase (arginase II) and comparison of its induction with nitric oxide synthase in a murine macrophage-like cell line Gotoh, T, Takiguchi, M, Terada, K, Mori, M, Nagasaki, A, Sonoki, T	FEBS Lett	1996
12859189	Human arginase II: crystal structure and physiological role in male and female sexual arousal Traish, AM, Cama, E, Shin, H, Emig, FA, Christianson, DW, Kim, NN, Colleluori, DM, Kim, SW, Ash, DE	Biochemistry	2003