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STAT5A,STAT5B [cytosol]
Stable Identifier
R-HSA-452094
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
cytosol
Synonyms
STAT5
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by FGFR in disease (Homo sapiens)
Signaling by FGFR1 in disease (Homo sapiens)
FGFR1 mutant receptor activation (Homo sapiens)
Signaling by cytosolic FGFR1 fusion mutants (Homo sapiens)
Phosphorylation of STAT5 by cytosolic FGFR1 fusions (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Growth hormone receptor signaling (Homo sapiens)
STAT5 association with GHR (Homo sapiens)
Growth Hormone:Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:STAT5 [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5 tyrosine phosphorylation (Homo sapiens)
Growth Hormone:Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:STAT5 [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
Prolactin receptor signaling (Homo sapiens)
PRLR binds STAT5 (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2:STAT5 [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
PRLR-bound STAT5 is phosphorylated (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2:STAT5 [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
Signaling by CSF3 (G-CSF) (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:STAT1,3,5 [plasma membrane] (Homo sapiens)
STAT1, STAT3, STAT5 [cytosol] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT1, STAT3, STAT5 [cytosol] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:STAT1,3,5 [plasma membrane] (Homo sapiens)
STAT1, STAT3, STAT5 [cytosol] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin-2 signaling (Homo sapiens)
Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
Recruited STAT5 is phosphorylated (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
Activation of STAT5a/b by JAK2 (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, activated JAK2:STAT5 [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
High affinity IL-5 receptor complex dimer, activated JAK2:STAT5 [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
IL3:IL3R active complex, activated JAK2:STAT5 [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5 is recruited by JAK2 (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, activated JAK2:STAT5 [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
High affinity IL-5 receptor complex dimer, activated JAK2:STAT5 [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
IL3:IL3R active complex, activated JAK2:STAT5 [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
Interleukin-7 signaling (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Erythropoietin (Homo sapiens)
Erythropoietin activates STAT5 (Homo sapiens)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5 (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:STAT5 [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:STAT5 [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
Signaling by Leptin (Homo sapiens)
JAK2 Phosphorylates STAT5 in Response to Leptin (Homo sapiens)
LEP:p-LEPR:p-JAK2:STAT5 [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
Phosphorylated LEPR Binds STAT5 (Homo sapiens)
LEP:p-LEPR:p-JAK2:STAT5 [plasma membrane] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
STAT5A,STAT5B [cytosol] (Homo sapiens)
Participants
members
STAT5A [cytosol]
(Homo sapiens)
STAT5B [cytosol]
(Homo sapiens)
Participates
as a component of
LEP:p-LEPR:p-JAK2:STAT5 [plasma membrane] (Homo sapiens)
Growth Hormone:Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:STAT5 [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, activated JAK2:STAT5 [plasma membrane] (Homo sapiens)
High affinity IL-5 receptor complex dimer, activated JAK2:STAT5 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, activated JAK2:STAT5 [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:STAT5 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2:STAT5 [plasma membrane] (Homo sapiens)
as an input of
Phosphorylated LEPR Binds STAT5 (Homo sapiens)
STAT5 association with GHR (Homo sapiens)
Phosphorylation of STAT5 by cytosolic FGFR1 fusions (Homo sapiens)
STAT5 is recruited by JAK2 (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Homo sapiens)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5 (Homo sapiens)
Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Homo sapiens)
PRLR binds STAT5 (Homo sapiens)
as a member of
STAT1, STAT3, STAT5 [cytosol] (Homo sapiens)
Inferred To
STAT5A,STAT5B [cytosol]
(Bos taurus)
STAT5A,STAT5B [cytosol]
(Canis familiaris)
STAT5A,STAT5B [cytosol]
(Gallus gallus)
STAT5A,STAT5B [cytosol]
(Mus musculus)
STAT5A,STAT5B [cytosol]
(Rattus norvegicus)
STAT5A,STAT5B [cytosol]
(Sus scrofa)
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