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RAB5A [endosome membrane]
Stable Identifier
R-HSA-452257
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endosome membrane
Synonyms
Ras-related protein Rab-5A, RAB5A_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q9H7C4 SYNCI
Expand all
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
Rabenosyn-5 connects Rab5 to VPS-45 (Homo sapiens)
RAB5A [endosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20339 RAB5A
Gene Names
RAB5A, RAB5
Chain
chain:1-215
Reference Genes
BioGPS Gene:5868 RAB5A
COSMIC (genes):RAB5A RAB5A
CTD Gene:5868 RAB5A
dbSNP Gene:5868 RAB5A
ENSEMBL:ENSG00000144566 RAB5A
ENSEMBL_homo_sapiens_GENE:ENSG00000144566.11 RAB5A
HGNC:9783 RAB5A
KEGG Gene (Homo sapiens):5868 RAB5A
Monarch:5868 RAB5A
NCBI Gene:5868 RAB5A
OMIM:179512 RAB5A
UCSC:P20339 RAB5A
Reference Transcript
RefSeq:NM_001292048.1 RAB5A
RefSeq:NM_004162.4 RAB5A
Other Identifiers
11722789_a_at
11722790_s_at
11748693_a_at
11748694_x_at
16938253
206113_PM_s_at
206113_s_at
209089_PM_at
209089_at
2613387
2613388
2613389
2613392
2613393
2613414
2613415
2613416
2613421
2613422
2613423
2613424
2613425
36110_at
5868
600_at
8078214
A_14_P110757
A_23_P212545
A_24_P208809
GE57902
GO:0000166
GO:0001726
GO:0003824
GO:0003924
GO:0003925
GO:0005515
GO:0005525
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005769
GO:0005829
GO:0005856
GO:0005886
GO:0006886
GO:0006897
GO:0006909
GO:0006914
GO:0008021
GO:0010008
GO:0012505
GO:0015031
GO:0015629
GO:0016020
GO:0016192
GO:0016787
GO:0019001
GO:0019003
GO:0023052
GO:0030139
GO:0030424
GO:0030425
GO:0030669
GO:0030670
GO:0031410
GO:0031623
GO:0031901
GO:0032009
GO:0036465
GO:0036477
GO:0042470
GO:0042995
GO:0043025
GO:0043195
GO:0043226
GO:0043231
GO:0043679
GO:0044788
GO:0045022
GO:0045121
GO:0045335
GO:0045921
GO:0048169
GO:0051036
GO:0051489
GO:0060070
GO:0070062
GO:0098559
GO:0098772
GO:0098842
GO:0150093
GO:2000300
GO:2000785
HMNXSV003030000
ILMN_1805800
M28215_at
PH_hs_0004227
TC03000111.hg
g12654846_3p_at
g4759003_3p_a_at
Participates
as a component of
Rabenosyn-5:VPS-45 [endosome membrane] (Homo sapiens)
as an input of
Rabenosyn-5 connects Rab5 to VPS-45 (Homo sapiens)
Other forms of this molecule
GGC-RAB5A [clathrin-coated endocytic vesicle membrane]
GGC-RAB5A [early endosome membrane]
GGC-RAB5A [cytosol]
RAB5A [early endosome membrane]
RAB5A [cytosol]
GGC-RAB5A [macropinosome membrane]
Inferred To
rab5aa [endosome membrane]
(Danio rerio)
RAB5A [endosome membrane]
(Bos taurus)
RAB5A [endosome membrane]
(Canis familiaris)
RAB5A [endosome membrane]
(Dictyostelium discoideum)
RAB5A [endosome membrane]
(Drosophila melanogaster)
RAB5A [endosome membrane]
(Gallus gallus)
RAB5A [endosome membrane]
(Mus musculus)
RAB5A [endosome membrane]
(Plasmodium falciparum)
RAB5A [endosome membrane]
(Rattus norvegicus)
RAB5A [endosome membrane]
(Saccharomyces cerevisiae)
RAB5A [endosome membrane]
(Schizosaccharomyces pombe)
RAB5A [endosome membrane]
(Sus scrofa)
rab-5 [endosome membrane]
(Caenorhabditis elegans)
rab5ab [endosome membrane]
(Danio rerio)
Homologues of RAB5A [endosome membrane]
(Danio rerio)
Homologues of RAB5A [endosome membrane]
(Plasmodium falciparum)
Homologues of RAB5A [endosome membrane]
(Saccharomyces cerevisiae)
Cross References
RefSeq
NP_001278977.1
,
NP_004153.2
OpenTargets
ENSG00000144566
IntEnz
3.6.5.2
GeneCards
P20339
HPA
ENSG00000144566-RAB5A
Ensembl
ENST00000422242
,
ENSG00000144566
,
ENSP00000411941
,
ENST00000273047
,
ENSP00000273047
PRO
P20339
Pharos - Targets
P20339
HMDB Protein
HMDBP08510
PDB
1N6N
,
1N6O
,
1R2Q
,
1N6I
,
1N6P
,
1N6K
,
1TU3
,
7BL1
,
4Q9U
,
1N6H
,
1N6R
,
3MJH
,
1N6L
,
1TU4
Interactors (34)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UKG1 APPL1
1
APPL1 [endosome membrane]
(R-HSA-373630)
0.841
23
UniProt:Q01968 OCRL
4
OCRL [Golgi membrane]
(R-HSA-434339)
OCRL [cytoplasmic vesicle membrane]
(R-HSA-434214)
OCRL [plasma membrane]
(R-HSA-3769049)
OCRL [cytosol]
(R-HSA-1806196)
0.799
11
UniProt:Q9UH99 SUN2
1
SUN2 [nuclear envelope]
(R-HSA-912382)
0.798
6
UniProt:Q15075 EEA1
1
EEA1 [endosome membrane]
(R-HSA-187893)
0.765
4
UniProt:P51148 RAB5C
10
RAB5C [azurophil granule membrane]
(R-HSA-6799338)
RAB5C [plasma membrane]
(R-HSA-6806265)
GGC-RAB5C [macropinosome membrane]
(R-HSA-9837694)
RAB5C [cytosol]
(R-HSA-8870413)
GGC-RAB5C [cytosol]
(R-HSA-8870436)
GGC-RAB5C [early endosome membrane]
(R-HSA-8875331)
RAB5C [early endosome membrane]
(R-HSA-8854157)
RAB5C [cytoplasmic vesicle membrane]
(R-HSA-434198)
RAB5C [Golgi membrane]
(R-HSA-434334)
GGC-RAB5C [clathrin-coated endocytic vesicle membrane]
(R-HSA-8871129)
0.744
5
UniProt:P50395 GDI2
4
GDI2 [cytosol]
(R-HSA-195089)
GDI2 [secretory granule lumen]
(R-HSA-6800904)
GDI2 [extracellular region]
(R-HSA-6806176)
GDI2 [azurophil granule lumen]
(R-HSA-6799337)
0.725
7
UniProt:P31150 GDI1
1
GDI1 [cytosol]
(R-HSA-195106)
0.725
7
UniProt:P26374 CHML
1
CHML [cytosol]
(R-HSA-8870443)
0.671
5
UniProt:Q92696 RABGGTA
2
RABGGTA [plasma membrane]
(R-HSA-6801086)
RABGGTA [cytosol]
(R-HSA-8870418)
0.671
5
UniProt:P24386 CHM
1
CHM [cytosol]
(R-HSA-6801097)
0.671
5
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
10
UniProt:P53611 RABGGTB
2
RABGGTB [plasma membrane]
(R-HSA-6801098)
RABGGTB [cytosol]
(R-HSA-8870419)
0.569
3
UniProt:P23727
3
PIK3R1 [plasma membrane]
(R-BTA-198365)
PIK3R1 [cytosol]
(R-BTA-74789)
PIK3R1 [cytosol]
(R-BTA-3080572)
0.558
5
UniProt:Q96PV4 PNMA5
0.556
3
UniProt:O15273 TCAP
1
TCAP [cytosol]
(R-HSA-390571)
0.556
3
UniProt:O15287 FANCG
2
FANCG [nucleoplasm]
(R-HSA-419532)
FANCG [cytosol]
(R-HSA-420788)
0.556
3
UniProt:P17024 ZNF20
1
ZNF20 [nucleoplasm]
(R-HSA-975024)
0.556
3
UniProt:O60506-4 SYNCRIP
0.556
3
UniProt:Q96HB5 CC120
0.556
3
UniProt:Q9H7C4 SYNCI
0.556
3
UniProt:Q9NS73-5 MBIP
0.556
3
UniProt:Q8TAB5 CA216
0.556
3
UniProt:P15923-3 TCF3
0.556
3
UniProt:Q9UQM7 CAMK2A
6
p-T286-CAMK2A [plasma membrane]
(R-HSA-432796)
p-T286-CAMK2A [nucleoplasm]
(R-HSA-444797)
p-T286-CAMK2A [endocytic vesicle membrane]
(R-HSA-416999)
p-T286,T305,T306-CAMK2A [cytosol]
(R-HSA-4332334)
CAMK2A [cytosol]
(R-HSA-4332329)
p-T286-CAMK2A [cytosol]
(R-HSA-445368)
0.556
3
UniProt:Q6ZQX7-4 Q6ZQX74
0.556
3
UniProt:Q9Y3D0 CIAO2B
1
FAM96B [cytosol]
(R-HSA-2161124)
0.556
3
UniProt:Q0VD86 INCA1
0.556
3
UniProt:Q6IAA8 LAMTOR1
5
LAMTOR1 [specific granule membrane]
(R-HSA-6799631)
LAMTOR1 [lysosomal membrane]
(R-HSA-5653582)
LAMTOR1 [azurophil granule membrane]
(R-HSA-6799633)
LAMTOR1 [plasma membrane]
(R-HSA-6806270)
LAMTOR1 [ficolin-1-rich granule membrane]
(R-HSA-6801003)
0.556
3
UniProt:P14136 GFAP
3
p-GFAP [lysosomal membrane]
(R-HSA-9626054)
GFAP [lysosomal membrane]
(R-HSA-9625195)
GFAP [cytosol]
(R-HSA-1253311)
0.556
3
UniProt:Q9P2R3 ANKFY1
1
ANKFY1 [endosome membrane]
(R-HSA-9693267)
0.544
2
UniProt:O95260 ATE1
0.527
3
UniProt:Q6ZMI0 PPR21
0.525
2
UniProt:Q8NEU8 DP13B
0.519
2
UniProt:Q15836 VAMP3
6
VAMP3 [recycling endosome membrane]
(R-HSA-2029063)
VAMP3 [phagocytic vesicle membrane]
(R-HSA-2029013)
VAMP3 [plasma membrane]
(R-HSA-8867599)
VAMP3 [trans-Golgi network membrane]
(R-HSA-6814624)
VAMP3 [transport vesicle]
(R-HSA-6814625)
VAMP3 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869130)
0.483
2
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