PYGB dimer, b form + 2 AMP <=> PYGB b dimer:AMP complex

Stable Identifier
R-HSA-453356
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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PYGB dimer, b form + 2 AMP <=> PYGB b dimer:AMP complex
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Cytosolic, non-phosphorylated PGYB dimers (b form) can reversibly bind AMP. This reaction is inferred from the AMP-binding properties of human PGYL and closely homologous PGYM proteins from other species (Newgard et al. 1989; Rath et al. 2000).
Literature References
PubMed ID Title Journal Year
10949035 Activation of human liver glycogen phosphorylase by alteration of the secondary structure and packing of the catalytic core

Danley, DE, Mansour, MN, Ammirati, M, Pandit, J, Schulte, GK, LeMotte, PK, Wasilko, DJ, Fennell, KF, Rath, VL, Hynes, TR

Mol Cell 2000
2667896 The family of glycogen phosphorylases: structure and function

Hwang, PK, Newgard, CB, Fletterick, RJ

Crit Rev Biochem Mol Biol 1989
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PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Homo sapiens)
Authored
D'Eustachio, P  (2010-01-22)
Created
D'Eustachio, P  (2010-01-22)
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