PIAS4 SUMOylates VDR with SUMO2

Stable Identifier
R-HSA-4546387
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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E3 SUMO-protein ligase (PIAS4) SUMOylates Vitamin D3 receptor (VDR) with SUMO2 (Jena et al. 2012). SUMOylation inhibits transcriptional activation by VDR in response to vitamin D.
Literature References
PubMed ID Title Journal Year
22564762 PIAS4 represses vitamin D receptor-mediated signaling and acts as an E3-SUMO ligase towards vitamin D receptor

Lee, WP, Thompson, PD, Doherty, D, Jena, S

J. Steroid Biochem. Mol. Biol. 2012
Participants
Participates
Catalyst Activity

SUMO transferase activity of PIAS4 [nucleoplasm]

Orthologous Events
Authored
Reviewed
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