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Ack-HIST1H2AB [nucleoplasm]
Stable Identifier
R-HSA-4551332
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
HATs acetylate histones (Homo sapiens)
NuA4 complex acetylates histone H2A, HIST1H4 (Homo sapiens)
AcK-histone H2A, AcK-HIST1H4 [nucleoplasm] (Homo sapiens)
AcK-histone H2A [nucleoplasm] (Homo sapiens)
AcK-histone HIST1H2A [nucleoplasm] (Homo sapiens)
Ack-HIST1H2AB [nucleoplasm] (Homo sapiens)
HDACs deacetylate histones (Homo sapiens)
HDAC10 deacetylates histone (Homo sapiens)
Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
AcK-histone H2A [nucleoplasm] (Homo sapiens)
AcK-histone HIST1H2A [nucleoplasm] (Homo sapiens)
Ack-HIST1H2AB [nucleoplasm] (Homo sapiens)
HDAC1:2-containing complex deacetylate histones (Homo sapiens)
Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
AcK-histone H2A [nucleoplasm] (Homo sapiens)
AcK-histone HIST1H2A [nucleoplasm] (Homo sapiens)
Ack-HIST1H2AB [nucleoplasm] (Homo sapiens)
HDAC3 containing complexes deacetylate histone (Homo sapiens)
Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
AcK-histone H2A [nucleoplasm] (Homo sapiens)
AcK-histone HIST1H2A [nucleoplasm] (Homo sapiens)
Ack-HIST1H2AB [nucleoplasm] (Homo sapiens)
HDAC8 deacetylates histones (Homo sapiens)
Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
AcK-histone H2A [nucleoplasm] (Homo sapiens)
AcK-histone HIST1H2A [nucleoplasm] (Homo sapiens)
Ack-HIST1H2AB [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HCMV Infection (Homo sapiens)
HCMV Early Events (Homo sapiens)
Activation of Latent HCMV Genome (Homo sapiens)
Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
AcK-histone H2A [nucleoplasm] (Homo sapiens)
AcK-histone HIST1H2A [nucleoplasm] (Homo sapiens)
Ack-HIST1H2AB [nucleoplasm] (Homo sapiens)
Delayed Early (DE) Gene Expression (Homo sapiens)
Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
AcK-histone H2A [nucleoplasm] (Homo sapiens)
AcK-histone HIST1H2A [nucleoplasm] (Homo sapiens)
Ack-HIST1H2AB [nucleoplasm] (Homo sapiens)
Immediate Early (IE) Gene Expression (Homo sapiens)
Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
AcK-histone H2A [nucleoplasm] (Homo sapiens)
AcK-histone HIST1H2A [nucleoplasm] (Homo sapiens)
Ack-HIST1H2AB [nucleoplasm] (Homo sapiens)
Transcriptional Activation of the HCMV Genome (Homo sapiens)
Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
AcK-histone H2A [nucleoplasm] (Homo sapiens)
AcK-histone HIST1H2A [nucleoplasm] (Homo sapiens)
Ack-HIST1H2AB [nucleoplasm] (Homo sapiens)
Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
AcK-histone H2A [nucleoplasm] (Homo sapiens)
AcK-histone HIST1H2A [nucleoplasm] (Homo sapiens)
Ack-HIST1H2AB [nucleoplasm] (Homo sapiens)
HCMV Late Events (Homo sapiens)
Late (L) Gene Expression (Homo sapiens)
Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
AcK-histone H2A [nucleoplasm] (Homo sapiens)
AcK-histone HIST1H2A [nucleoplasm] (Homo sapiens)
Ack-HIST1H2AB [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04908 H2AC4
Gene Names
H2AC4, H2AFM, HIST1H2AB, H2AC8, H2AFA, HIST1H2AE
Chain
initiator methionine:, chain:2-130
Reference Genes
BioGPS Gene:3012 H2AC4
BioGPS Gene:8335 H2AC4
CTD Gene:3012 H2AC4
CTD Gene:8335 H2AC4
dbSNP Gene:3012 H2AC4
dbSNP Gene:8335 H2AC4
ENSEMBL:ENSG00000277075 HIST1H2AE
ENSEMBL:ENSG00000278463 HIST1H2AB
ENSEMBL_homo_sapiens_GENE:ENSG00000277075.3 H2AC4
ENSEMBL_homo_sapiens_GENE:ENSG00000278463.2 H2AC4
HGNC:4724 H2AC4
HGNC:4734 H2AC4
KEGG Gene (Homo sapiens):3012 H2AC4
KEGG Gene (Homo sapiens):8335 H2AC4
Monarch:3012 H2AC4
Monarch:8335 H2AC4
NCBI Gene:3012 H2AC4
NCBI Gene:8335 H2AC4
OMIM:602786 H2AC4
OMIM:602795 H2AC4
Reference Transcript
RefSeq:NM_021052.2 H2AC4
RefSeq:NM_003513.2 H2AC4
Other Identifiers
11731693_at
11731694_s_at
11741215_at
17005589
17016366
208569_PM_at
208569_at
214469_PM_at
214469_at
2899224
2899225
2899226
2946220
2946221
2946222
2946223
2946224
3012
35127_at
8117408
8124391
8335
A_14_P115530
A_23_P59045
A_24_P223384
GE504811
GE62562
GO:0000786
GO:0003677
GO:0005198
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005694
GO:0006325
GO:0008285
GO:0030527
GO:0043226
GO:0043229
GO:0043505
GO:0046982
GO:0061644
GO:0070062
HMNXSV003010811
HMNXSV003012591
Hs.121017.0.S1_3p_at
ILMN_1753524
ILMN_1756849
M60752_at
PH_hs_0006702
PH_hs_0013174
PH_hs_0032313
TC06000173.hg
TC06001343.hg
Z83741_at
g4504246_3p_at
Participates
as a member of
AcK-histone HIST1H2A [nucleoplasm] (Homo sapiens)
Other forms of this molecule
K63polyUb-HIST1H2AB [nucleoplasm]
Ub-HIST1H2AB [nucleoplasm]
Ack6-HIST1H2AB [nucleoplasm]
Me2aR30-HIST1H2AB [nucleoplasm]
MeR30-HIST1H2AB [nucleoplasm]
Me2aR4-HIST1H2AB [nucleoplasm]
MeR4-HIST1H2AB [nucleoplasm]
Me2sR4-HIST1H2AB [nucleoplasm]
Me2aR12-HIST1H2AB [nucleoplasm]
MeR12-HIST1H2AB [nucleoplasm]
HIST1H2AB [extracellular region]
HIST1H2AB [nucleoplasm]
Inferred To
Hist1h2ap [nucleoplasm]
(Mus musculus)
HTA1 [nucleoplasm]
(Saccharomyces cerevisiae)
HTA2 [nucleoplasm]
(Saccharomyces cerevisiae)
H2Av2 [nucleoplasm]
(Dictyostelium discoideum)
His2A:CG33862 [nucleoplasm]
(Drosophila melanogaster)
Hist1h2ao [nucleoplasm]
(Mus musculus)
hta1 [nucleoplasm]
(Schizosaccharomyces pombe)
Hist1h2af [nucleoplasm]
(Mus musculus)
H2ac12 [nucleoplasm]
(Mus musculus)
hta2 [nucleoplasm]
(Schizosaccharomyces pombe)
H2AC4 [nucleoplasm]
(Canis familiaris)
Ack-HIST1H2AB [nucleoplasm]
(Bos taurus)
Ack-HIST1H2AB [nucleoplasm]
(Gallus gallus)
Ack-HIST1H2AB [nucleoplasm]
(Plasmodium falciparum)
h2ax1 [nucleoplasm]
(Danio rerio)
H2ac4 [nucleoplasm]
(Mus musculus)
zgc:56685 [nucleoplasm]
(Danio rerio)
H2ac6 [nucleoplasm]
(Mus musculus)
Hist1h2an [nucleoplasm]
(Mus musculus)
H2AC8 [nucleoplasm]
(Sus scrofa)
H2ac15 [nucleoplasm]
(Mus musculus)
Homologues of Ack-HIST1H2AB [nucleoplasm]
(Danio rerio)
Homologues of Ack-HIST1H2AB [nucleoplasm]
(Dictyostelium discoideum)
Homologues of Ack-HIST1H2AB [nucleoplasm]
(Drosophila melanogaster)
Homologues of Ack-HIST1H2AB [nucleoplasm]
(Mus musculus)
Homologues of Ack-HIST1H2AB [nucleoplasm]
(Saccharomyces cerevisiae)
Homologues of Ack-HIST1H2AB [nucleoplasm]
(Schizosaccharomyces pombe)
H2AX [nucleoplasm]
(Dictyostelium discoideum)
H2Av3 [nucleoplasm]
(Dictyostelium discoideum)
H2Av1 [nucleoplasm]
(Dictyostelium discoideum)
H2ac8 [nucleoplasm]
(Mus musculus)
H2ac11 [nucleoplasm]
(Mus musculus)
His2A:CG33859 [nucleoplasm]
(Drosophila melanogaster)
Modified Residues
Name
N6-acetyl-L-lysine at unknown position
PsiMod Name
N6-acetyl-L-lysine [MOD:00064]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Cross References
RefSeq
NP_003504.2
,
NP_066390.1
OpenTargets
ENSG00000278463
GeneCards
P04908
HPA
ENSG00000277075-H2AC8
,
ENSG00000278463-H2AC4
Ensembl
ENST00000303910
,
ENSG00000277075
,
ENST00000615868
,
ENSP00000483842
,
ENSP00000303373
,
ENSG00000278463
PRO
P04908
Pharos - Targets
P04908
HMDB Protein
HMDBP07727
PDB
6V92
,
5GXQ
,
6KE9
,
7COW
,
7K5Y
,
7BWD
,
6A5O
,
8U13
,
6T90
,
3AZG
,
8GRM
,
7WBW
,
6HKT
,
6T7D
,
5Z23
,
8IHL
,
7XSX
,
3A6N
,
5B2I
,
6INQ
,
7XVL
,
3AZI
,
7XCT
,
8JNE
,
6ACL
,
7XTI
,
6IPU
,
7PFX
,
3AYW
,
6HTS
,
8YTI
,
6LER
,
6L49
,
7PFA
,
7WBX
,
7PEX
,
5B32
,
7SCZ
,
5AY8
,
8SNA
,
8SN3
,
6R8Z
,
8I17
,
5GSE
,
8UQ9
,
6LE9
,
7PF6
,
8HAN
,
8U14
,
8SMW
,
6J50
,
8JH3
,
6E0P
,
8SN6
,
7PFF
,
2RVQ
,
7PF3
,
7PEY
,
5GTC
,
8JND
,
8HAK
,
6E0C
,
7XSE
,
5B0Z
,
7PF2
,
3W99
,
8WG5
,
5XF5
,
7DBP
,
6R92
,
8HAJ
,
8XBT
,
8JLA
,
5AV5
,
7CCR
,
6LA9
,
3AZN
,
6J51
,
7PFT
,
5Y0C
,
5AV9
,
7PET
,
7V99
,
3AZM
,
7WBV
,
5JRG
,
6R91
,
7PEU
,
7NL0
,
3AV1
,
8TXW
,
5XF3
,
8TXX
,
8OTT
,
7XX6
,
6JXD
,
8JH2
,
6A5U
,
5B2J
,
3WKJ
,
6A5T
,
6BUZ
,
6LAB
,
6JR1
,
7PFW
,
7SCY
,
8IEG
,
3W96
,
3WTP
,
6M3V
,
8HAG
,
8JL9
,
8H0W
,
7LYC
,
6M44
,
7ZI4
,
8UQA
,
8Q3M
,
5AVC
,
8OSK
,
7XX5
,
8Q3E
,
7Y00
,
8SMY
,
7K61
,
3AZJ
,
7V9J
,
8UPF
,
8HE5
,
3X1V
,
7K63
,
8SN8
,
5X7X
,
8SN9
,
7W9V
,
3AZE
,
7K5X
,
7V96
,
3AZF
,
8UQ8
,
6T7B
,
6O1D
,
6JR0
,
5B24
,
6T93
,
6T7C
,
5CPI
,
8JNF
,
5AVB
,
3X1S
,
7PFE
,
6A5P
,
6R8Y
,
7XTD
,
6J4W
,
8JLD
,
8SN0
,
6YOV
,
7BY0
,
7PFV
,
7BXT
,
7PEV
,
8JHG
,
8SN2
,
7XSZ
,
6L4A
,
7PEW
,
6KXV
,
7D1Z
,
7PF5
,
6AEE
,
7C0M
,
7XVM
,
6V2K
,
6A5L
,
8SN4
,
4YM5
,
7V90
,
7VCL
,
8KB5
,
7V9S
,
7XD1
,
5ZBX
,
8JH4
,
5B40
,
8SMX
,
8HAM
,
7PF4
,
6LA8
,
6J4Z
,
8G57
,
8OSJ
,
8HAL
,
8UQD
,
7PFD
,
7PEZ
,
7V9C
,
7XZZ
,
6J4X
,
7PFC
,
5B0Y
,
7PF0
,
8JLB
,
6R93
,
8HAI
,
7XZY
,
5AV6
,
3AZL
,
6R94
,
7CCQ
,
3AZK
,
6R90
,
4YM6
,
7D20
,
4Z5T
,
8XBU
,
5AV8
,
8TXV
,
3W98
,
3AZH
,
8H0V
,
6A5R
,
5XF4
,
6J4Y
,
7V9K
,
3AN2
,
7LYA
,
8UQB
,
7VZ4
,
8SN7
,
8UQC
,
7XCR
,
3AV2
,
6LA2
,
7XZX
,
8IEJ
,
7K60
,
7XT7
,
6L9Z
,
3AFA
,
8HAH
,
5B31
,
5Y0D
,
7LYB
,
6L9H
,
7PFU
,
8HR1
,
6USJ
,
8HQY
,
7XD0
,
8OSL
,
8SN5
,
3W97
,
6IQ4
,
6T7A
,
8OTS
,
8Q3X
,
6IR9
,
5CPK
,
8SMZ
,
8UQE
,
7VA4
,
2CV5
,
7Y7I
,
8SN1
,
6T79
,
8Q36
,
5CPJ
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62805 H4C1
17
polySUMO3-HIST1H4 [nucleoplasm]
(R-HSA-4570531)
monoSUMO1-HIST1H4 [nucleoplasm]
(R-HSA-4570518)
4xAcK-HIST1H4A [nucleoplasm]
(R-HSA-427390)
AcK5,12-HIST1H4A [nucleoplasm]
(R-HSA-212078)
AcK13-HIST1H4 [nucleoplasm]
(R-HSA-4568744)
Me2aR4-HIST1H4 [nucleoplasm]
(R-HSA-5229015)
Me2sR4-HIST1H4 [nucleoplasm]
(R-HSA-4754243)
MeR4-HIST1H4 [nucleoplasm]
(R-HSA-4754240)
Me3K21-HIST1H4 [nucleoplasm]
(R-HSA-5651656)
HIST1H4A [extracellular region]
(R-HSA-977569)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-427469)
AcK6-HIST1H4 [nucleoplasm]
(R-HSA-4568748)
AcK9-HIST1H4 [nucleoplasm]
(R-HSA-4568758)
MeK21-HIST1H4 [nucleoplasm]
(R-HSA-5423110)
AcK-HIST1H4 [nucleoplasm]
(R-HSA-3451124)
Me2K21-HIST1H4 [nucleoplasm]
(R-HSA-5651652)
HIST1H4 [nucleoplasm]
(R-HSA-181902)
0.874
12
UniProt:Q16695 H3-4
3
HIST3H3 [nucleoplasm]
(R-HSA-181914)
Me3K5-HIST3H3 [nucleoplasm]
(R-HSA-2245188)
Me2K5-HIST3H3 [nucleoplasm]
(R-HSA-2245186)
0.589
2
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