VANGL2 is phosphorylated in response to WNT5A

Stable Identifier
R-HSA-4551570
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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VANGL2 is phosphorylated in response to WNT5A
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Based on studies in mouse, human VANGL2 is predicted to be phosphorylated and activated in response to WNT5A, possibly by CK1delta. Phosphorylation occurs on serine and threonine residues in 2 clusters and appears to be primed by phosphorylation at S5, S82 and S84. VANGL2 phosphorylation and activation occurs in a graded fashion in response to WNT5A distribution, helping to establish PCP asymmetry (Gao et al, 2011).

Literature References
PubMed ID Title Journal Year
21316585 Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2

Song, H, Yang, Y, Garrett, L, Robinson, J, Economides, AN, Minami, Y, Bishop, K, English, MA, Gao, B, Sood, R, Andre, P, Elliot, G

Dev. Cell 2011
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Input
Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of unknown kinase [cytosol]

Physical Entity
unknown kinase [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
Vangl2 is phosphorylated in response to Wnt5a (Mus musculus)
Authored
Rothfels, K  (2013-09-12)
Reviewed
Kikuchi, A  (2013-11-13)
Created
Rothfels, K  (2013-09-14)
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