Reactome | WNT5A binds ROR2 and VANGL2

WNT5A binds ROR2 and VANGL2

Stable Identifier

R-HSA-4551571

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

WNT5A binds ROR2 and VANGL2 to promote PCP in mouse limb buds. A complex of WNT5A:ROR2:VANGL2 is established along the WNT5A gradient in chondrocytes and regulates VANGL2 phosphorylation. This initiates the establishment of PCP asymmetry in these cells, a hallmark of the PCP pathway (Gao et al, 2011). ROR2 has been shown to function as a receptor or co-receptor for WNT5A in other mammalian systems (Oishi et al, 2003; Mikels and Nusse, 2006; reviewed in Minami et al, 2010), and WNT5A:ROR2 signaling can also negatively regulate canonical beta-catenin-dependent transcription as assessed by reporter gene activity (Mikels and Nusse, 2006; Li et al, 2008).

Literature References

PubMed ID	Title	Journal	Year
21316585	Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2 Song, H, Yang, Y, Garrett, L, Robinson, J, Economides, AN, Minami, Y, Bishop, K, English, MA, Gao, B, Sood, R, Andre, P, Elliot, G	Dev. Cell	2011
19530173	Ror-family receptor tyrosine kinases in noncanonical Wnt signaling: their implications in developmental morphogenesis and human diseases Oishi, I, Minami, Y, Endo, M, Nishita, M	Dev. Dyn.	2010
18215320	Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2 Villosis, MF, Li, J, Sasaki, T, Xing, Y, Minoo, P, Minami, Y, Hu, L, Li, C, Chen, H, Nishita, M	BMC Mol. Biol.	2008
12839624	The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway Shibuya, H, Oishi, I, Minami, Y, Kani, S, Ohkawara, B, Koshida, I, Suzuki, K, Yamada, G, Mundlos, S, Suzuki, H, Takada, R, Onishi, N, Takada, S, Schwabe, GC	Genes Cells	2003
16602827	Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context Mikels, AJ, Nusse, R	PLoS Biol	2006