SUMOylation of RPA1 (RPA70) with SUMO2,3

Stable Identifier
R-HSA-4551616
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SUMOylation of RPA1 (RPA70) with SUMO2,3
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

RPA1 (RPA70) is SUMOylated at lysine-449 and lysine-577 with SUMO2,3 (Dou et al. 2010, Tammsalu et al. 2014). SUMOylation of RPA1 recruits RAD51 to sites of DNA damage to initiate repair through homologous recombination.

Literature References
PubMed ID Title Journal Year
24782567 Proteome-wide identification of SUMO2 modification sites

Tatham, MH, Hay, RT, Tammsalu, T, Ibrahim, AF, Jaffray, EG, Matic, I

Sci Signal 2014
20705237 Regulation of DNA repair through deSUMOylation and SUMOylation of replication protein A complex

Dou, H, Yeh, ET, Singh, M, Carpenter, PB, Huang, C

Mol. Cell 2010
Participants
Input
Output
Participates
as an event of
Catalyst Activity

SUMO transferase activity of UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm]

Physical Entity
UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
SUMOylation of RPA1 (RPA70) with SUMO2,3 (Danio rerio)
SUMOylation of RPA1 (RPA70) with SUMO2,3 (Drosophila melanogaster)
SUMOylation of RPA1 (RPA70) with SUMO2,3 (Gallus gallus)
SUMOylation of RPA1 (RPA70) with SUMO2,3 (Mus musculus)
SUMOylation of RPA1 (RPA70) with SUMO2,3 (Rattus norvegicus)
SUMOylation of RPA1 (RPA70) with SUMO2,3 (Xenopus tropicalis)
Authored
May, B  (2013-09-13)
Reviewed
Ferrari, S  (2015-02-21)
Created
May, B  (2013-09-14)
Cite Us!