Reactome | monoSUMO1-K494-CBX4 [nucleoplasm]

monoSUMO1-K494-CBX4 [nucleoplasm]

Stable Identifier

R-HSA-4551626

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

E3 SUMO-protein ligase CBX4 ecNumber6.3.2.-/ecNumber, CBX4_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O00257 CBX4

Gene Names

CBX4

Chain

chain:1-560

Reference Genes

COSMIC (genes):CBX4 CBX4

dbSNP Gene:8535 CBX4

ENSEMBL:ENSG00000141582 CBX4

Participates

as a component of

monoSUMO1-CBX4:PRC1 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

CBX4 [nucleoplasm]

Inferred To

Cbx4 [nucleoplasm] (Mus musculus)

Cbx4 [nucleoplasm] (Rattus norvegicus)

cbx4 [nucleoplasm] (Xenopus tropicalis)

CBX4 [nucleoplasm] (Bos taurus)

CBX4 [nucleoplasm] (Sus scrofa)

monoSUMO1-K494-CBX4 [nucleoplasm] (Gallus gallus)

Modified Residues

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 494

Coordinate

494

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35227 PCGF2	1	PCGF2 [nucleoplasm] (R-HSA-389115)	0.788	7
UniProt:Q13363 CTBP1	3	CTBP1 [nucleoplasm] (R-HSA-212372) polySUMO2,3-K428-CTBP1 [nucleoplasm] (R-HSA-3108226) monoSUMO1-K428-CTBP1 [nucleoplasm] (R-HSA-3108200)	0.695	5
UniProt:Q16665 HIF1A	7	HIF1A [nucleoplasm] (R-HSA-1234135) HIF1A [cytosol] (R-HSA-1234102) p-Y565-HIF1A [cytosol] (R-HSA-8857584) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) 2xHP-HIF1A [cytosol] (R-HSA-1234131) 2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) HN-HIF1A [cytosol] (R-HSA-1234110)	0.674	15
UniProt:Q9BYE7 PCGF6	1	PCGF6 [nucleoplasm] (R-HSA-8953572)	0.643	3
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.604	3
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382)	0.602	4

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