Reactome | HERC2 [nucleoplasm]

HERC2 [nucleoplasm]

Stable Identifier

R-HSA-4551680

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

E3 ubiquitin-protein ligase HERC2 ecNumber6.3.2.-/ecNumber, HERC2_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9Q2G4 Q9Q2G4

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of DNA damage response and repair proteins (Homo sapiens)
        
        PIAS4 SUMOylates HERC2 with SUMO1 (Homo sapiens)
        
        HERC2 [nucleoplasm] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
22508508	DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger Wikström, M, Nilsson, J, Povlsen, LK, Danielsen, JR, Streicher, W, Bekker-Jensen, S, Villumsen, BH, Mailand, N	J. Cell Biol.	2012

External Reference Information

External Reference

UniProt:O95714 HERC2

Gene Names

HERC2

Chain

chain:1-4834

Reference Genes

BioGPS Gene:8924 HERC2

COSMIC (genes):HERC2 HERC2

CTD Gene:8924 HERC2

dbSNP Gene:8924 HERC2

ENSEMBL:ENSG00000128731 HERC2

HGNC:4868 HERC2

KEGG:hsa:8924 HERC2

Monarch:8924 HERC2

NCBI Gene:8924 HERC2

OMIM:605837 HERC2

UCSC:O95714 HERC2

Reference Transcript

RefSeq:NM_004667.5 HERC2

Other Identifiers

11743778_a_at

11743779_at

11746294_s_at

11749565_s_at

16805832

16806279

17121148

17121150

17121168

17121366

17121368

17121370

17121376

17121470

17121474

17121476

17121482

217902_PM_s_at

217902_s_at

222461_PM_s_at

222461_s_at

3583008

3583011

3583869

3583870

3583918

3583922

3584067

3584068

3585555

3585557

3585750

3585759

3585762

3585763

3585764

3585766

3585767

3585769

3585770

3585773

3585774

3585775

3585776

3585779

3585780

3585782

3585783

3585785

3585786

3585788

3585789

3585790

3585793

3585795

3585799

3585800

3585804

3585805

3585806

3585807

3585808

3585809

3585818

3585819

3585821

3585822

3586777

3586789

3586791

3586801

3586802

3586803

3586804

3586805

3586807

3586811

3586812

3612434

3612435

3612437

3612438

3612439

3612442

3612448

3612450

3612453

3612455

3612459

3612462

3612463

3612464

3612465

3612467

3612468

3612471

3612472

3612474

3612475

3612477

3612519

3613473

3613474

3613478

3613479

3613486

3613488

3613489

3613494

3613495

3613497

3613500

3613502

3613504

3613505

3613506

3613508

3613512

3613515

3613516

3613517

3613520

3613522

3613523

3613524

3613525

3613527

3614902

3614903

3614904

3614905

3614907

3614909

3614910

3614911

3614912

3614913

3614914

3614915

3614916

3614917

3614918

3614920

3614921

3614922

3614923

3614924

3614926

3614927

3614928

3614929

3614930

3614931

3614932

3614933

3614934

3614935

3614936

3614937

3614938

3614939

3614940

3614942

3614945

3614946

3614947

3614950

3614951

3614952

3614953

3614954

3614955

3614956

3614957

3614958

3614959

3614960

3614962

3614963

3614965

3614966

3614967

3614968

3614970

3614971

3614973

3614974

3614975

3614978

3614980

3614982

3614983

3614984

3614985

3614986

3614987

3614989

3614990

3614992

3614993

3614994

3614995

3614996

3614998

3614999

3615001

3615002

3615003

3615004

3615005

3615006

3615007

3615008

3615009

3615010

3615012

3615013

3615014

3615015

3615017

3615018

3615019

3615020

3615022

3615023

3615025

3615026

3615027

3615028

3615030

3615031

3615032

3615033

3615034

3615036

3615038

3615039

3615040

3615041

3615042

3615043

3615044

3615046

3615048

3615049

3615052

3615062

3615236

3615280

3615282

3657695

3657706

3657709

3657711

3657714

3657715

3657727

3657728

3657729

3657730

3658108

3658116

3658119

3658122

3658124

3658128

3658129

3658135

3658136

3658137

3658138

3688592

3688593

3688594

3688595

3688604

3688605

3688609

3688611

3688614

3688618

3688627

3688954

3688955

3688956

3688957

3688966

3688967

3688970

3688972

3688974

3688983

3689009

4038807

4038810

4038820

4039177

4039181

4039188

4039189

4039192

4039215

4039218

51165_at

7982154

7986569

7986701

7986863

8001099

89112_at

8924

89333_at

A_21_P0011298

A_21_P0011394

A_21_P0011396

A_21_P0011429

A_21_P0011430

A_23_P33407

GE79170

GE849954

GO:0003824

GO:0004842

GO:0005085

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005814

GO:0005829

GO:0005856

GO:0005886

GO:0006281

GO:0006886

GO:0006974

GO:0007283

GO:0008270

GO:0016020

GO:0016567

GO:0016740

GO:0022414

GO:0030154

GO:0030163

GO:0030182

GO:0031625

GO:0032183

GO:0043161

GO:0043226

GO:0045746

GO:0046872

GO:0061630

GO:0098772

GO:0140096

HMNXSV003002621

HMNXSV003005213

HMNXSV003024544

HMNXSV003039677

Hs.266933.0.S1_3p_a_at

Hs.307352.0.S1_3p_s_at

ILMN_1654170

ILMN_1666485

ILMN_1812787

ILMN_1813475

PH_hs_0025355

TC15000142.hg

TC15000143.hg

TC15000144.hg

TC15001092.hg

TC15002105.hg

TC15002126.hg

TC15002423.hg

TC15002437.hg

g5729867_3p_a_at

Participates

as an input of

as a component of

DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

p-T4827-HERC2 [nucleoplasm]

p-T4827,SUMO1-HERC2 [nucleoplasm]

HERC2 [cytosol]

monoSUMO1-HERC2 [nucleoplasm]

Inferred To

Herc2 [nucleoplasm] (Rattus norvegicus)

HERC2 [nucleoplasm] (Bos taurus)

HERC2 [nucleoplasm] (Canis familiaris)

HERC2 [nucleoplasm] (Dictyostelium discoideum)

HERC2 [nucleoplasm] (Drosophila melanogaster)

HERC2 [nucleoplasm] (Gallus gallus)

HERC2 [nucleoplasm] (Mus musculus)

HERC2 [nucleoplasm] (Plasmodium falciparum)

HERC2 [nucleoplasm] (Sus scrofa)

herc2 [nucleoplasm] (Xenopus tropicalis)

Ghost homologue of HERC2 [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of HERC2 [nucleoplasm] (Schizosaccharomyces pombe)

Homologues of HERC2 [nucleoplasm] (Dictyostelium discoideum)

Homologues of HERC2 [nucleoplasm] (Plasmodium falciparum)

Cross References

RefSeq

NP_004658.3

OpenTargets

ENSG00000128731

ENSEMBL

ENSP00000261609, ENST00000261609

HPA

ENSG00000128731-HERC2

PRO

O95714

Pharos - Targets

O95714

GlyGen

O95714

Orphanet

HERC2

HMDB Protein

HMDBP08656

PDB

7Q44, 7Q42, 7Q43, 7Q45, 4L1M, 2KEO, 7Q40, 7Q46, 7Q41, 6WW3, 6WW4, 3KCI, 7RGW

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16659 MAPK6 gene	6	p-3S,T MAPK6 [nucleoplasm] (R-HSA-5692665) MAPK6 [nucleoplasm] (R-HSA-5692686) p-S189 MAPK6 [nucleoplasm] (R-HSA-5687015) p-S189 MAPK6 [cytosol] (R-HSA-5687019) MAPK6 [cytosol] (R-HSA-5686979) ub-MAPK6 [cytosol] (R-HSA-5687000)	0.837	8
UniProt:P23025 XPA	1	XPA [nucleoplasm] (R-HSA-67437)	0.677	6
UniProt:Q9BXG8 SPZ1			0.669	3
UniProt:Q9UKA1 FBXL5	1	FBXL5 [cytosol] (R-HSA-391295)	0.623	4
UniProt:Q9UJU6 DBNL	7	DBNL [ficolin-1-rich granule lumen] (R-HSA-6801510) DBNL [tertiary granule lumen] (R-HSA-6801516) DBNL [extracellular region] (R-HSA-6801604) DBNL [secretory granule lumen] (R-HSA-6801520) DBNL(1-361) [cytosol] (R-HSA-202925) DBNL(362-431) [cytosol] (R-HSA-202933) DBNL [cytosol] (R-HSA-202880)	0.564	3
UniProt:Q9NRI5 DISC1			0.547	3
UniProt:Q9BQB4 SOST	1	SOST [extracellular region] (R-HSA-3769322)	0.527	3
UniProt:Q99856 ARID3A	1	ARID3A [nucleoplasm] (R-HSA-3782552)	0.527	2
UniProt:Q9HBT8 ZNF286A	1	ZNF286A [nucleoplasm] (R-HSA-1027429)	0.527	2
UniProt:Q08380 LGALS3BP	2	LGALS3BP [extracellular region] (R-HSA-8848882) LGALS3BP [platelet dense granule lumen] (R-HSA-8848916)	0.527	2
UniProt:Q9Y5T5 USP16	1	USP16 [nucleoplasm] (R-HSA-5690106)	0.527	2
UniProt:Q5SW79-2 CEP170			0.527	4
UniProt:Q1ED39 KNOP1			0.527	2
UniProt:Q99767 APBA2	1	APBA2 [cytosol] (R-HSA-6794245)	0.527	2
UniProt:O60232 ZNRD2			0.527	3
UniProt:Q9Y262 EIF3L	1	EIF3L [cytosol] (R-HSA-377452)	0.527	2
UniProt:Q8NCA5 FA98A			0.527	3
UniProt:Q13772 NCOA4	1	NCOA4 [nucleoplasm] (R-HSA-8940259)	0.527	2
UniProt:Q96LW4 PRIPO			0.527	2
UniProt:Q9Y2K6 USP20	1	USP20 [cytosol] (R-HSA-5696946)	0.527	2
UniProt:P31689 DNAJA1	2	SOH-C149,C150-DNAJA1 [cytosol] (R-HSA-9857072) DNAJA1 [cytosol] (R-HSA-3371544)	0.527	2
UniProt:O15371 EIF3D	1	EIF3D [cytosol] (R-HSA-72548)	0.527	2
UniProt:Q99613 EIF3C	1	EIF3C [cytosol] (R-HSA-72550)	0.527	2
UniProt:Q05086-2 UBE3A			0.499	5
UniProt:O75821 EIF3G	1	EIF3G [cytosol] (R-HSA-72538)	0.483	2
UniProt:Q9Q2G4 Q9Q2G4			0.462	2