Reactome | monoSUMO1-K159,171,196-VHL [nucleoplasm]

monoSUMO1-K159,171,196-VHL [nucleoplasm]

Stable Identifier

R-HSA-4551697

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser for interactor UniProt:Q15369 ELOC

Expand all

External Reference Information

External Reference

UniProt:P40337 VHL

Gene Names

VHL

Chain

chain:1-213

Reference Genes

BioGPS Gene:7428 VHL

COSMIC (genes):VHL VHL

CTD Gene:7428 VHL

dbSNP Gene:7428 VHL

ENSEMBL:ENSG00000134086 VHL

ENSEMBL_homo_sapiens_GENE:ENSG00000134086.9 VHL

HGNC:12687 VHL

KEGG Gene (Homo sapiens):7428 VHL

Monarch:7428 VHL

NCBI Gene:7428 VHL

OMIM:608537 VHL

UCSC:P40337 VHL

Reference Transcript

Other Identifiers

11748633_a_at

11752180_x_at

1559227_PM_s_at

1559227_s_at

1668_s_at

16937571

203844_PM_at

203844_at

2610338

2610339

2610340

2610342

2610344

2610345

2610346

2610347

2610348

2610349

2610350

2610351

2610352

2610353

2610354

40871_at

7428

8077781

A_23_P132606

A_24_P134942

A_33_P3419938

GE54104

GO:0000122

GO:0000902

GO:0003711

GO:0003714

GO:0003824

GO:0004842

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005783

GO:0005829

GO:0005886

GO:0006351

GO:0006355

GO:0006508

GO:0006914

GO:0008285

GO:0009968

GO:0010468

GO:0010507

GO:0010629

GO:0012501

GO:0016020

GO:0016567

GO:0016740

GO:0019899

GO:0023052

GO:0030154

GO:0030163

GO:0034244

GO:0036211

GO:0043066

GO:0043161

GO:0043226

GO:0043232

GO:0045597

GO:0045893

GO:0046426

GO:0048856

GO:0050821

GO:0060090

GO:0071456

GO:0140096

GO:0140110

GO:0140297

GO:1900037

GO:1904262

GO:1990000

GO:1990756

HMNXSV003025175

Hs2.421597.1.A1_3p_s_at

ILMN_1738579

ILMN_1801984

ILMN_2376625

L15409_at

PH_hs_0033268

TC03000055.hg

TC03002213.hg

g4507890_3p_at

Participates

as an output of

PIAS4 SUMOylates VHL with SUMO1 (Homo sapiens)

Other forms of this molecule

VHL [nucleoplasm]

VHL [cytosol]

Inferred To

Vhl [nucleoplasm] (Mus musculus)

Vhl [nucleoplasm] (Rattus norvegicus)

vhl [nucleoplasm] (Danio rerio)

monoSUMO1-K159,171,196-VHL [nucleoplasm] (Bos taurus)

monoSUMO1-K159,171,196-VHL [nucleoplasm] (Gallus gallus)

vhl-1 [nucleoplasm] (Caenorhabditis elegans)

Modified Residues

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 159

Coordinate

159

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 171

Coordinate

171

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 196

Coordinate

196

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_937799.1, NP_000542.1

Guide to Pharmacology - Targets

3204

OpenTargets

ENSG00000134086

ZINC - Substances

VHL_HUMAN

ZINC target

P40337

PRO

P40337

PDB

6GMX, 4WQO, 4W9G, 6R6H, 3ZTD, 8BB2, 8VLB, 8BB3, 3ZTC, 8P0F, 8QW7, 8QW6, 6GMR, 4AWJ, 6I7Q, 7Z77, 8G1Q, 5NVY, 6HAX, 8CQK, 8RX0, 1LQB, 5NVZ, 6HAY, 4W9I, 8G1P, 8FY2, 8FY1, 7CJB, 4W9D, 8BDX, 3ZRF, 6ZHC, 6HR2, 8PC2, 8BDO, 8R5H, 8QU8, 7PI4, 8BDN, 8BDJ, 6GFY, 6FMJ, 8C13, 8CQL, 6GFZ, 5NW1, 8EI3, 5NW0, 4W9J, 8BB4, 1LM8, 4W9E, 8BB5, 5LLI, 4B95, 7S4E, 4W9F, 4AJY, 8VL9, 6GMQ, 8QJS, 8QJR, 8QVU, 6GMN, 4W9C, 6BVB, 4B9K, 6I7R, 8RWZ, 4BKT, 8BDI, 6FMI, 7KHH, 1VCB, 8BEB, 4W9H, 5NVW, 8CQE, 5NVX, 7ZNT, 3ZRC, 5NVV, 5T35, 8BDT, 8FY0, 8BDS, 7Q2J, 8BDM, 3ZUN, 5N4W, 8EWV, 8BDL, 6R7F, 6SIS, 4BKS, 7Z76, 6FMK, 4W9K, 7JTP, 4W9L, 5NW2, 6GFX, 7JTO, 7Z6L

HPA

ENSG00000134086-VHL

GeneCards

P40337

Ensembl

ENSP00000256474, ENSP00000344757, ENST00000256474, ENSG00000134086, ENST00000345392

Pharos - Targets

P40337

Orphanet

15708

ZINC - Predictions - Purchasable

VHL_HUMAN

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16665 HIF1A	7	HN-HIF1A [cytosol] (R-HSA-1234110) 2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) 2xHP-HIF1A [cytosol] (R-HSA-1234131) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) p-Y565-HIF1A [cytosol] (R-HSA-8857584) HIF1A [cytosol] (R-HSA-1234102) HIF1A [nucleoplasm] (R-HSA-1234135)	0.962	22
UniProt:Q15370 ELOB	2	TCEB2 [nucleoplasm] (R-HSA-112423) ELOB [cytosol] (R-HSA-180551)	0.94	13
UniProt:Q13617 CUL2	3	G76-NEDD8-K689-CUL2 [cytosol] (R-HSA-8952511) CUL2 [nucleoplasm] (R-HSA-1234126) CUL2 [cytosol] (R-HSA-416982)	0.916	19
UniProt:Q15369 ELOC	2	TCEB1 [nucleoplasm] (R-HSA-112422) ELOC [cytosol] (R-HSA-180535)	0.871	10
UniProt:Q99750 MDFI			0.666	4
UniProt:Q99814 EPAS1 (HIF2A)	5	HN-EPAS1 [cytosol] (R-HSA-1234112) 2xHP-EPAS1 [nucleoplasm] (R-HSA-1234151) 2xHP-EPAS1 [cytosol] (R-HSA-1234149) EPAS1 [nucleoplasm] (R-HSA-452560) EPAS1 [cytosol] (R-HSA-1234119)	0.659	3
UniProt:P62877 RBX1	2	RBX1 [nucleoplasm] (R-HSA-1234142) RBX1 [cytosol] (R-HSA-180582)	0.623	4
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.611	9
UniProt:P0C6X7-PRO_0000037322 REP			0.602	7
UniProt:P21980 TGM2			0.602	10
UniProt:Q99873 PRMT1	2	PRMT1 [cytosol] (R-HSA-9632173) PRMT1 [nucleoplasm] (R-HSA-3215140)	0.508	2
UniProt:Q61221	7	Hif1a [cytosol] (R-MMU-1234110) Hif1a [nucleoplasm] (R-MMU-1234105) Hif1a [cytosol] (R-MMU-1234131) phospho-Hif1a [cytosol] (R-MMU-9634700) phospho-Hif1a [cytosol] (R-MMU-8857584) Hif1a [cytosol] (R-MMU-1234102) Hif1a [nucleoplasm] (R-MMU-1234135)	0.499	3
UniProt:P02751 FN1	10	FN1(32-2386) [platelet alpha granule lumen] (R-HSA-114620) FN1(32-271) [extracellular region] (R-HSA-3787935) FN1(272-2386) [extracellular region] (R-HSA-3788024) FN1(32-?) [extracellular region] (R-HSA-2533850) FN1(?-2386) [extracellular region] (R-HSA-2533841) FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713462) FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713459) p-FN1 [endoplasmic reticulum lumen] (R-HSA-8956937) FN1 [endoplasmic reticulum lumen] (R-HSA-8956708) FN1(32-2386) [extracellular region] (R-HSA-54851)	0.499	2
UniProt:Q13231 CHIT1	3	CHIT1 [specific granule lumen] (R-HSA-6799529) CHIT1 [extracellular region] (R-HSA-6786396) CHIT1 [tertiary granule lumen] (R-HSA-6800898)	0.499	2
UniProt:Q05513 PRKCZ	5	p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698) PRKCZ [cytosol] (R-HSA-58218) PRKCZ [cell junction] (R-HSA-2134483) p-T410-PRKCZ [cytosol] (R-HSA-437181) pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824)	0.463	3
UniProt:P08151 GLI1	9	ub-GLI1 [cytosol] (R-HSA-5635833) ub-pS-GLI1 [ciliary base] (R-HSA-5610514) pS-GLI1 [ciliary base] (R-HSA-5610497) GLI1 [cytosol] (R-HSA-445457) p-GLI1 [ciliary tip] (R-HSA-5635040) 2p-GLI1 [nucleoplasm] (R-HSA-5635057) p-GLI1 [nucleoplasm] (R-HSA-5635042) GLI1 [ciliary tip] (R-HSA-5610360) GLI1 [ciliary base] (R-HSA-5610357)	0.463	2

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