Reactome | monoSUMO1-K159,171,196-VHL [nucleoplasm]

monoSUMO1-K159,171,196-VHL [nucleoplasm]

Stable Identifier

R-HSA-4551697

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser for interactor UniProt:Q61221

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External Reference Information

External Reference

UniProt:P40337 VHL

Gene Names

VHL

Chain

chain:1-213

Reference Genes

COSMIC (genes):VHL VHL

dbSNP Gene:7428 VHL

ENSEMBL:ENSG00000134086 VHL

Participates

as an output of

PIAS4 SUMOylates VHL with SUMO1 (Homo sapiens)

Other forms of this molecule

VHL [nucleoplasm]

VHL [cytosol]

Inferred To

Vhl [nucleoplasm] (Mus musculus)

Vhl [nucleoplasm] (Rattus norvegicus)

vhl [nucleoplasm] (Danio rerio)

monoSUMO1-K159,171,196-VHL [nucleoplasm] (Bos taurus)

monoSUMO1-K159,171,196-VHL [nucleoplasm] (Gallus gallus)

vhl-1 [nucleoplasm] (Caenorhabditis elegans)

Modified Residues

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 159

Coordinate

159

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 171

Coordinate

171

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 196

Coordinate

196

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16665 HIF1A	7	HIF1A [nucleoplasm] (R-HSA-1234135) HIF1A [cytosol] (R-HSA-1234102) p-Y565-HIF1A [cytosol] (R-HSA-8857584) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) 2xHP-HIF1A [cytosol] (R-HSA-1234131) 2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) HN-HIF1A [cytosol] (R-HSA-1234110)	0.962	22
UniProt:Q15370 ELOB	2	TCEB2 [nucleoplasm] (R-HSA-112423) ELOB [cytosol] (R-HSA-180551)	0.94	13
UniProt:Q13617 CUL2	3	CUL2 [cytosol] (R-HSA-416982) CUL2 [nucleoplasm] (R-HSA-1234126) G76-NEDD8-K689-CUL2 [cytosol] (R-HSA-8952511)	0.916	19
UniProt:Q15369 ELOC	2	TCEB1 [nucleoplasm] (R-HSA-112422) ELOC [cytosol] (R-HSA-180535)	0.871	10
UniProt:Q99750 MDFI			0.666	4
UniProt:Q99814 EPAS1 (HIF2A)	5	EPAS1 [cytosol] (R-HSA-1234119) EPAS1 [nucleoplasm] (R-HSA-452560) 2xHP-EPAS1 [cytosol] (R-HSA-1234149) 2xHP-EPAS1 [nucleoplasm] (R-HSA-1234151) HN-EPAS1 [cytosol] (R-HSA-1234112)	0.659	3
UniProt:P62877 RBX1	2	RBX1 [cytosol] (R-HSA-180582) RBX1 [nucleoplasm] (R-HSA-1234142)	0.623	4
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.611	9
UniProt:P0C6X7-PRO_0000037322 REP			0.602	7
UniProt:P21980 TGM2			0.602	10
UniProt:Q99873 PRMT1	2	PRMT1 [nucleoplasm] (R-HSA-3215140) PRMT1 [cytosol] (R-HSA-9632173)	0.508	2
UniProt:Q13231 CHIT1	3	CHIT1 [specific granule lumen] (R-HSA-6799529) CHIT1 [extracellular region] (R-HSA-6786396) CHIT1 [tertiary granule lumen] (R-HSA-6800898)	0.499	2
UniProt:Q61221	7	Hif1a [cytosol] (R-MMU-1234110) Hif1a [nucleoplasm] (R-MMU-1234105) Hif1a [cytosol] (R-MMU-1234131) phospho-Hif1a [cytosol] (R-MMU-9634700) phospho-Hif1a [cytosol] (R-MMU-8857584) Hif1a [cytosol] (R-MMU-1234102) Hif1a [nucleoplasm] (R-MMU-1234135)	0.499	3
UniProt:P02751 FN1	10	FN1(32-2386) [extracellular region] (R-HSA-54851) FN1 [endoplasmic reticulum lumen] (R-HSA-8956708) p-FN1 [endoplasmic reticulum lumen] (R-HSA-8956937) FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713459) FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713462) FN1(?-2386) [extracellular region] (R-HSA-2533841) FN1(32-?) [extracellular region] (R-HSA-2533850) FN1(272-2386) [extracellular region] (R-HSA-3788024) FN1(32-271) [extracellular region] (R-HSA-3787935) FN1(32-2386) [platelet alpha granule lumen] (R-HSA-114620)	0.499	2
UniProt:Q05513 PRKCZ	5	pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824) PRKCZ [cytosol] (R-HSA-58218) p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698) p-T410-PRKCZ [cytosol] (R-HSA-437181) PRKCZ [cell junction] (R-HSA-2134483)	0.463	3
UniProt:P08151 GLI1	9	ub-GLI1 [cytosol] (R-HSA-5635833) ub-pS-GLI1 [ciliary base] (R-HSA-5610514) pS-GLI1 [ciliary base] (R-HSA-5610497) GLI1 [cytosol] (R-HSA-445457) p-GLI1 [ciliary tip] (R-HSA-5635040) 2p-GLI1 [nucleoplasm] (R-HSA-5635057) p-GLI1 [nucleoplasm] (R-HSA-5635042) GLI1 [ciliary base] (R-HSA-5610357) GLI1 [ciliary tip] (R-HSA-5610360)	0.463	2

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