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polySUMO2-K2652,K2725-RANBP2 [nuclear envelope]
Stable Identifier
R-HSA-4551720
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nuclear envelope
Synonyms
E3 SUMO-protein ligase RanBP2 ecNumber6.3.2.-/ecNumber, RBP2_HUMAN, NUP358
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of SUMOylation proteins (Homo sapiens)
RANBP2 SUMOylates RANBP2 with SUMO2 (Homo sapiens)
polySUMO2-K2652,K2725-RANBP2 [nuclear envelope] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
25218447
Uncovering global SUMOylation signaling networks in a site-specific manner
Yang, B
,
Hendriks, IA
,
Verlaan-de Vries, M
,
Vertegaal, AC
,
D'Souza, RC
,
Mann, M
Nat. Struct. Mol. Biol.
2014
External Reference Information
External Reference
UniProt:P49792 RANBP2
Gene Names
RANBP2, NUP358
Chain
chain:1-3224
Reference Genes
BioGPS Gene:5903 RANBP2
COSMIC (genes):RANBP2 RANBP2
CTD Gene:5903 RANBP2
dbSNP Gene:5903 RANBP2
ENSEMBL:ENSG00000153201 RANBP2
HGNC:9848 RANBP2
KEGG:hsa:5903 RANBP2
Monarch:5903 RANBP2
NCBI Gene:5903 RANBP2
OMIM:601181 RANBP2
UCSC:P49792 RANBP2
Reference Transcript
RefSeq:NM_006267.4 RANBP2
Other Identifiers
11722814_s_at
11722815_at
11722816_at
11754283_s_at
11758005_s_at
16884126
201711_PM_x_at
201711_x_at
201712_PM_s_at
201712_s_at
201713_PM_s_at
201713_s_at
226922_PM_at
226922_at
242712_PM_x_at
242712_x_at
2492220
2492221
2492223
2492290
2492297
2492298
2492302
2492303
2492304
2492305
2492307
2492308
2492309
2492310
2492312
2492313
2492315
2492316
2492317
2492326
2492332
2498739
2498744
2498745
2498746
2498747
2498748
2498750
2498751
2498752
2498753
2498754
2498755
2498756
2498757
2498758
2498759
2498763
2498764
2498765
2498766
2499126
2499159
2499160
2499162
2499163
2499164
2499165
2499166
2499167
2499169
2499170
2499171
2499172
2499173
2499174
2499175
2499176
2499177
2499178
2499179
2499180
2499181
2499182
2499183
2499184
2499185
2499186
2499187
2499188
2499189
2499190
2499191
2499192
2499193
2499194
2499195
2499196
2499197
2499200
2499201
2499202
2499203
2499204
2499205
2499206
2499207
2499208
2499209
2499210
2499211
2499217
2499219
2499223
2499225
2499227
2499229
2499231
2499235
2499236
2499237
2499238
2499239
2499619
2499620
2499621
2499623
2499624
2499625
2499626
2499628
2499631
2499633
2499634
2499635
2499636
2499637
2499638
2499640
2499641
2499642
2499643
2499644
2499645
2499648
2499649
2499650
2499652
2563427
2563428
2563430
2563431
2563432
2563434
2563436
2563437
2563438
2563439
2563440
2563442
2563443
2563444
2563445
2563446
2563447
2563448
2563450
2563452
2563455
2563456
2563458
2569095
2569096
2569097
2569098
2569102
2569103
2569104
2569105
2569106
2569107
2569108
2569109
2569110
2569111
2569112
2569113
2569116
2569117
2569118
2569119
2569120
2570482
2570484
2570486
2570488
2570490
2570491
2570493
2570494
2570495
2570497
2570498
2570499
2570500
2570501
2570503
2570507
2570510
2570511
2570512
2570513
2570515
2570516
2570517
2570556
2570557
2570559
2570561
2570564
2570566
2570567
2570569
2570570
2570571
2570573
2570574
2570575
2570576
2570577
2570578
2570580
2570583
2570588
2570589
2570590
2570591
2570593
2570594
2570595
2571299
2571300
2571302
2571303
2571305
2571306
2571308
2571309
2571310
2571312
2571313
2571314
2571315
2571316
2571317
2571319
2571322
2571326
2571327
2571328
2571329
2571331
2571332
2571333
2571335
3125190
32788_at
3748175
51177_at
5903
62295_at
8044161
8044263
8044304
8054414
8054532
8054557
8054676
82452_i_at
82453_r_at
A_14_P108565
A_14_P113906
A_23_P131664
A_24_P350890
A_33_P3272390
A_33_P3308740
D42063_at
GE61553
GE80234
GO:0000413
GO:0001975
GO:0003723
GO:0003755
GO:0003824
GO:0005096
GO:0005515
GO:0005634
GO:0005635
GO:0005642
GO:0005643
GO:0005654
GO:0005737
GO:0005829
GO:0006111
GO:0006457
GO:0006607
GO:0006886
GO:0006913
GO:0015031
GO:0016018
GO:0016020
GO:0016740
GO:0016853
GO:0016925
GO:0019789
GO:0031267
GO:0031965
GO:0042405
GO:0043226
GO:0043231
GO:0044614
GO:0044615
GO:0044877
GO:0046872
GO:0046907
GO:0051028
GO:0051168
GO:0051642
GO:0061665
GO:0098772
GO:0106068
GO:0140096
GO:1990723
HMNXSV003021186
HMNXSV003037067
Hs.167822.0.S1_3p_at
Hs.199179.0.S1_3p_s_at
Hs.28248.0.A1_3p_at
ILMN_1654866
ILMN_1681811
ILMN_2320574
PH_hs_0011701
TC02000668.hg
TC02004500.hg
g6382078_3p_a_at
g924266_3p_a_at
Participates
as an output of
RANBP2 SUMOylates RANBP2 with SUMO2 (Homo sapiens)
Other forms of this molecule
RANBP2 [cytosol]
RANBP2(1-867)-ALK(1058-1620) fusion [cytosol]
RANBP2(1-867)-p-7Y-ALK(1058-1620) fusion [cytosol]
RANBP2 [nuclear envelope]
monoSUMO1-K2592,K2650,K2723-RANBP2 [nuclear envelope]
Inferred To
ranbp2 [nuclear envelope]
(Xenopus tropicalis)
Nup358 [nuclear envelope]
(Drosophila melanogaster)
polySUMO2-K2652,K2725-RANBP2 [nuclear envelope]
(Dictyostelium discoideum)
polySUMO2-K2652,K2725-RANBP2 [nuclear envelope]
(Gallus gallus)
polySUMO2-K2652,K2725-RANBP2 [nuclear envelope]
(Plasmodium falciparum)
ranbp1 [nuclear envelope]
(Dictyostelium discoideum)
Homologues of polySUMO2-K2652,K2725-RANBP2 [nuclear envelope]
(Dictyostelium discoideum)
Ranbp2 [nuclear envelope]
(Mus musculus)
Ranbp2 [nuclear envelope]
(Rattus norvegicus)
RANBP2 [nuclear envelope]
(Bos taurus)
RANBP2 [nuclear envelope]
(Sus scrofa)
Modified Residues
Name
sumoylated lysine (polySUMO2 [nucleoplasm]) at 2652
Coordinate
2652
Modification
polySUMO2 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Name
sumoylated lysine (polySUMO2 [nucleoplasm]) at 2725
Coordinate
2725
Modification
polySUMO2 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
NP_006258.3
OpenTargets
ENSG00000153201
ENSEMBL
ENST00000283195
,
ENSP00000283195
HPA
ENSG00000153201-RANBP2
PRO
P49792
Pharos - Targets
P49792
Orphanet
RANBP2
GlyGen
P49792
HMDB Protein
HMDBP08534
PDB
7MNK
,
7MNZ
,
3UIP
,
7R5K
,
7MNY
,
3UIO
,
7MNV
,
4GA0
,
7MNT
,
7MNW
,
1XKE
,
7MNL
,
7MNN
,
7MNU
,
7MNM
,
7MNO
,
2LAS
,
1RRP
,
5CLL
,
4LQW
,
1Z5S
,
7MNP
,
7MNR
,
4L6E
,
7MNQ
,
7MNS
,
5CLQ
,
7MNJ
,
3UIN
,
7MNX
,
7R5J
,
4I9Y
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62826 RAN
2
RAN [cytosol]
(R-HSA-165540)
RAN [nucleoplasm]
(R-HSA-165528)
0.861
7
UniProt:P63279 UBE2I
9
monoSUMO1-K14-UBE2I [nucleoplasm]
(R-HSA-4085358)
UBE2I [nuclear envelope]
(R-HSA-4655408)
SUMO2-C93-UBE2I [cytosol]
(R-HSA-4656944)
SUMO3-C93-UBE2I [nucleoplasm]
(R-HSA-3730629)
UBE2I [nucleoplasm]
(R-HSA-912481)
SUMO1-C93-UBE2I [nucleoplasm]
(R-HSA-3730617)
SUMO2-C93-UBE2I [nucleoplasm]
(R-HSA-3730619)
SUMO1-C93-UBE2I [cytosol]
(R-HSA-4656909)
UBE2I [cytosol]
(R-HSA-4655342)
0.854
7
UniProt:P46060 RANGAP1
3
RANGAP1 [cytosol]
(R-HSA-376255)
RANGAP1 [nuclear envelope]
(R-HSA-167661)
monoSUMO1-K524-RANGAP1 [nuclear envelope]
(R-HSA-3000416)
0.713
5
UniProt:O60260 PARK2
4
polyUb-PARK2 [cytosol]
(R-HSA-5689094)
p-S9-PRKN [cytosol]
(R-HSA-9793481)
p-S65-PRKN [cytosol]
(R-HSA-9834954)
PRKN [cytosol]
(R-HSA-201579)
0.639
11
UniProt:Q921C5-1 BICD2
0.633
4
UniProt:P52292 KPNA2
2
KPNA2 [cytosol]
(R-HSA-205976)
KPNA2 [nucleoplasm]
(R-HSA-206045)
0.547
2
UniProt:Q9BPX7 CG025
0.544
3
UniProt:P61769 B2M
11
B2M(21-119) [plasma membrane]
(R-HSA-167743)
B2M(21-119) [endoplasmic reticulum lumen]
(R-HSA-983063)
B2M(21-119) [specific granule lumen]
(R-HSA-6806144)
B2M(21-119) [extracellular region]
(R-HSA-1302721)
B2M(21-119) [tertiary granule lumen]
(R-HSA-6800179)
B2M(21-119) [Golgi membrane]
(R-HSA-983403)
B2M(21-119) [ER to Golgi transport vesicle membrane]
(R-HSA-983378)
B2M(21-119) [early endosome lumen]
(R-HSA-1236827)
B2M(21-119) [recycling endosome membrane]
(R-HSA-8863880)
B2M(21-119) [phagocytic vesicle membrane]
(R-HSA-1236891)
B2M(21-119) [early endosome membrane]
(R-HSA-182298)
0.527
4
UniProt:Q14974 KPNB1
5
KPNB1 [cytosol]
(R-HSA-180733)
KPNB1 [nucleoplasm]
(R-HSA-180714)
KPNB1 [specific granule lumen]
(R-HSA-6799646)
KPNB1 [extracellular region]
(R-HSA-6806306)
KPNB1 [ficolin-1-rich granule lumen]
(R-HSA-6800978)
0.527
2
UniProt:O14524 NEMP1
0.527
3
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:Q9UBU9 NXF1
2
NXF1 [nucleoplasm]
(R-HSA-111690)
NXF1 [cytosol]
(R-HSA-156481)
0.527
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
6
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 Y772_A775dup [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.463
3
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