PIAS4 SUMOylates HERC2 with SUMO1

Stable Identifier
R-HSA-4551724
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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PIAS4 SUMOylates HERC2 at an unknown lysine residue with SUMO1 (Danielsen et al. 2012). HERC2 binds SUMO1 and is then SUMOylated. SUMOylation of HERC2 promotes binding to RNF8 at double-strand breaks in DNA.
Literature References
PubMed ID Title Journal Year
22508508 DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger

Wikström, M, Nilsson, J, Povlsen, LK, Danielsen, JR, Streicher, W, Bekker-Jensen, S, Villumsen, BH, Mailand, N

J. Cell Biol. 2012
Participants
Participates
Catalyst Activity

SUMO transferase activity of PIAS4 [nucleoplasm]

Orthologous Events
Authored
Reviewed
Created
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