Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
monoSUMO1-K210-XRCC4 [nucleoplasm]
Stable Identifier
R-HSA-4568892
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
DNA repair protein XRCC4
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of DNA damage response and repair proteins (Homo sapiens)
PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Homo sapiens)
monoSUMO1-K210-XRCC4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13426 XRCC4
Gene Names
XRCC4
Chain
chain:1-336, chain:266-336
Reference Genes
BioGPS Gene:7518 XRCC4
COSMIC (genes):XRCC4 XRCC4
CTD Gene:7518 XRCC4
dbSNP Gene:7518 XRCC4
ENSEMBL:ENSG00000152422 XRCC4
ENSEMBL_homo_sapiens_GENE:ENSG00000152422.16 XRCC4
HGNC:12831 XRCC4
KEGG Gene (Homo sapiens):7518 XRCC4
Monarch:7518 XRCC4
NCBI Gene:7518 XRCC4
OMIM:194363 XRCC4
UCSC:Q13426 XRCC4
Reference Transcript
RefSeq:NM_003401.4 XRCC4
RefSeq:NM_001318012.1 XRCC4
RefSeq:NM_022406.3 XRCC4
RefSeq:NM_001318013.1 XRCC4
RefSeq:NM_022550.3 XRCC4
RefSeq:XM_011543626.1 XRCC4
Other Identifiers
11725853_a_at
11741323_a_at
11744799_a_at
1360_at
16986895
205071_PM_x_at
205071_x_at
205072_PM_s_at
205072_s_at
210813_PM_s_at
210813_s_at
2818455
2818456
2818459
2818460
2818471
2818475
2818478
2818487
2818488
2818489
2818500
2818501
7518
8106730
A_14_P201832
A_23_P122174
GE62459
GO:0002376
GO:0003677
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0005958
GO:0006281
GO:0006302
GO:0006303
GO:0006310
GO:0006974
GO:0010165
GO:0032807
GO:0033152
GO:0035861
GO:0042802
GO:0043226
GO:0048856
GO:0051103
GO:0051351
GO:0070419
GO:0070975
GO:0071285
GO:1990166
HMNXSV003032393
HMNXSV003051475
ILMN_2379695
PH_hs_0009095
TC05000411.hg
U40622_at
g12081904_3p_a_at
g12081904_3p_x_at
g12408646_3p_a_at
Participates
as an output of
PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Homo sapiens)
Other forms of this molecule
XRCC4 [nucleoplasm]
Inferred To
Xrcc4 [nucleoplasm]
(Mus musculus)
Xrcc4 [nucleoplasm]
(Rattus norvegicus)
XRCC4 [nucleoplasm]
(Bos taurus)
XRCC4 [nucleoplasm]
(Gallus gallus)
xrcc4 [nucleoplasm]
(Dictyostelium discoideum)
xrcc4 [nucleoplasm]
(Xenopus tropicalis)
Modified Residues
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 210
Coordinate
210
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
NP_003392.1
,
NP_072044.1
,
NP_001304941.1
,
NP_001304942.1
,
NP_071801.1
,
XP_011541928.1
OpenTargets
ENSG00000152422
GeneCards
Q13426
HPA
ENSG00000152422-XRCC4
Ensembl
ENSP00000379344
,
ENSG00000152422
,
ENSP00000282268
,
ENSP00000421491
,
ENST00000338635
,
ENST00000282268
,
ENST00000511817
,
ENSP00000342011
,
ENST00000396027
PRO
Q13426
Pharos - Targets
Q13426
Orphanet
23795
PDB
5CJ4
,
3W03
,
7LT3
,
8BHV
,
8EZA
,
1IK9
,
5E50
,
7NFC
,
3II6
,
7LSY
,
4XA4
,
3RWR
,
8BH3
,
5CHX
,
3MUD
,
8BHY
,
8EZB
,
3SR2
,
7NFE
,
1FU1
,
3Q4F
,
5WLZ
,
8BOT
,
5CJ0
,
5WJ7
,
6ABO
,
7M3P
Interactors (29)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49917 LIG4
1
LIG4 [nucleoplasm]
(R-HSA-53791)
0.964
22
UniProt:Q96T60 PNKP
1
PNKP [nucleoplasm]
(R-HSA-5649651)
0.942
18
UniProt:Q9H9Q4 NHEJ1
1
NHEJ1 [nucleoplasm]
(R-HSA-5687247)
0.868
11
UniProt:Q8IW19 APLF
0.844
6
UniProt:Q13426 XRCC4
2
monoSUMO1-K210-XRCC4 [nucleoplasm]
(R-HSA-4568892)
XRCC4 [nucleoplasm]
(R-HSA-75911)
0.844
7
UniProt:Q8IZU0 FAM9B
0.831
9
UniProt:Q7Z2E3 APTX
0.785
6
UniProt:Q0D2I5 IFFO1
0.771
7
UniProt:P12956 XRCC6
5
XRCC6 [secretory granule lumen]
(R-HSA-6801312)
XRCC6 [extracellular region]
(R-HSA-6806444)
XRCC6 [ficolin-1-rich granule lumen]
(R-HSA-6801300)
XRCC6 [cytosol]
(R-HSA-3134813)
XRCC6 [nucleoplasm]
(R-HSA-58272)
0.656
3
UniProt:Q9H9Q4-1 NHEJ1
0.642
4
UniProt:O00499 BIN1
1
BIN1 [cytosol]
(R-HSA-8868265)
0.625
4
UniProt:Q0D2I5-5 IFFO1
0.591
4
UniProt:P43360 MAGA6
0.556
3
UniProt:Q7Z3Y8 KRT27
1
KRT27 [cytosol]
(R-HSA-6809587)
0.556
3
UniProt:Q2TB18 ASTE1
0.556
3
UniProt:Q9NVX0 HAUS2
1
HAUS2 [cytosol]
(R-HSA-380274)
0.556
3
UniProt:O15499 GSC2
0.556
3
UniProt:Q13426-3 XRCC4
0.556
3
UniProt:Q96FJ2 DYNLL2
4
DYNLL2 [cytosol]
(R-HSA-2029024)
DYNLL2 [plasma membrane]
(R-HSA-140527)
DYNLL2 [cilium]
(R-HSA-5624865)
DYNLL2 [ciliary tip]
(R-HSA-5625337)
0.527
2
UniProt:Q96QD9 FYTTD1
1
FYTTD1 [nucleoplasm]
(R-HSA-8852176)
0.527
2
UniProt:Q92624 APBP2
0.527
3
UniProt:Q9NPJ6 MED4
1
MED4 [nucleoplasm]
(R-HSA-350263)
0.527
3
UniProt:P63167 DYNLL1
6
DYNLL1 [ciliary tip]
(R-HSA-5625335)
DYNLL1 [cilium]
(R-HSA-5624863)
DYNLL1 [ficolin-1-rich granule membrane]
(R-HSA-6801518)
DYNLL1 [tertiary granule membrane]
(R-HSA-6801482)
DYNLL1 [plasma membrane]
(R-HSA-54017)
DYNLL1 [cytosol]
(R-HSA-387105)
0.527
2
UniProt:Q1L5Z9 LONF2
0.527
3
UniProt:Q8IUD6 RNF135
1
RNF135 [cytosol]
(R-HSA-936042)
0.527
2
UniProt:Q9NP50 SHCAF
0.527
2
UniProt:Q5TF58 IFFO2
0.527
4
UniProt:P48729 CSNK1A1
2
CSNK1A1 [cytosol]
(R-HSA-195263)
CSNK1A1 [cilium]
(R-HSA-5632507)
0.527
2
UniProt:Q96SD1 DCLRE1C
3
p-S516,S645-DCLRE1C [nucleoplasm]
(R-HSA-5687176)
p-S645-DCLRE1C [nucleoplasm]
(R-HSA-5686708)
DCLRE1C [nucleoplasm]
(R-HSA-5686712)
0.462
3
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text