Reactome | polySUMO2-K422-HNRNPK [nucleoplasm]

polySUMO2-K422-HNRNPK [nucleoplasm]

Stable Identifier

R-HSA-4570532

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Heterogeneous nuclear ribonucleoprotein K, HNRPK_HUMAN

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
24782567	Proteome-wide identification of SUMO2 modification sites Tatham, MH, Hay, RT, Tammsalu, T, Ibrahim, AF, Jaffray, EG, Matic, I	Sci Signal	2014
25218447	Uncovering global SUMOylation signaling networks in a site-specific manner Yang, B, Hendriks, IA, Verlaan-de Vries, M, Vertegaal, AC, D'Souza, RC, Mann, M	Nat. Struct. Mol. Biol.	2014
25114211	Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli Impens, F, Cossart, P, Radoshevich, L, Ribet, D	Proc. Natl. Acad. Sci. U.S.A.	2014

External Reference Information

External Reference

UniProt:P61978 HNRNPK

Gene Names

HNRNPK, HNRPK

Chain

chain:1-463

Reference Genes

COSMIC (genes):HNRNPK HNRNPK

dbSNP Gene:3190 HNRNPK

ENSEMBL:ENSG00000165119 HNRNPK

Participates

as an output of

CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Homo sapiens)

Other forms of this molecule

HNRNPK [nucleoplasm]

Inferred To

HnRNP-K [nucleoplasm] (Drosophila melanogaster)

hnrpkl [nucleoplasm] (Danio rerio)

hnrnpk [nucleoplasm] (Xenopus tropicalis)

polySUMO2-K422-HNRNPK [nucleoplasm] (Plasmodium falciparum)

polySUMO2-K422-HNRNPK [nucleoplasm] (Sus scrofa)

Hnrnpk [nucleoplasm] (Mus musculus)

Hnrnpk [nucleoplasm] (Rattus norvegicus)

HNRNPK [nucleoplasm] (Bos taurus)

HNRNPK [nucleoplasm] (Gallus gallus)

Modified Residues

Name

sumoylated lysine (polySUMO2 [nucleoplasm]) at 422

Coordinate

422

Modification

polySUMO2 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Interactors (74)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.848	10
UniProt:Q96PU8 QKI	2	QKI(1-504)-p-RAF1(278- 648) fusion [cytosol] (R-HSA-6802546) QKI(1-504)-RAF1(278-648) fusion [cytosol] (R-HSA-6802466)	0.821	7
UniProt:Q14011 CIRBP			0.8	9
UniProt:P38159 RBMX	2	RBMX [cytosol] (R-HSA-9715135) RBMX [nucleoplasm] (R-HSA-71939)	0.8	11
UniProt:Q9BTD8 RBM42	1	RBM42 [nucleoplasm] (R-HSA-9769526)	0.748	4
UniProt:P61978 HNRNPK	2	HNRNPK [nucleoplasm] (R-HSA-71945) polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532)	0.747	4
UniProt:P09012 SNRPA	1	SNRPA [nucleoplasm] (R-HSA-71915)	0.743	5
UniProt:P79522 PRR3			0.743	9
UniProt:Q07666 KHDRBS1	3	p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm] (R-HSA-8848970) p-Y435,Y440,Y443-KHDRBS1 [cytosol] (R-HSA-8848995) KHDRBS1 [nucleoplasm] (R-HSA-8848941)	0.668	3
UniProt:Q96PK6 RBM14	1	RBM14 [nucleoplasm] (R-HSA-8938345)	0.666	4
UniProt:Q96MU7 YTDC1			0.666	4
UniProt:Q15415 RBY1F			0.666	4
UniProt:P43243 MATR3			0.666	4
UniProt:Q66K41 Z385C			0.666	7
UniProt:Q5I0X4 CF226			0.666	7
UniProt:P29597 TYK2	5	p-Y1054-TYK2 [cytosol] (R-HSA-1112598) p-Y1054,Y1055-TYK2 [cytosol] (R-HSA-909682) TYK2 [cytosol] (R-HSA-877348) p-Y-TYK2 [cytosol] (R-HSA-6784366) p-TYK2 [cytosol] (R-HSA-8950424)	0.666	4
UniProt:O60504 SORBS3	1	SORBS3 [cytosol] (R-HSA-445805)	0.666	4
UniProt:P98179 RBM3			0.666	7
UniProt:Q9NYB9 ABI2	2	p-4S-ABI2 [cytosol] (R-HSA-2029003) ABI2 [cytosol] (R-HSA-1671647)	0.666	6
UniProt:Q01081 U2AF1	1	U2AF1 [nucleoplasm] (R-HSA-71985)	0.666	4
UniProt:Q8WVV9 HNRLL			0.666	9
UniProt:P14866 HNRNPL	1	HNRNPL [nucleoplasm] (R-HSA-71947)	0.649	5
UniProt:P29846-PRO_0000037666			0.639	9
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	15
UniProt:Q99873 PRMT1	2	PRMT1 [nucleoplasm] (R-HSA-3215140) PRMT1 [cytosol] (R-HSA-9632173)	0.602	3
UniProt:P11387 TOP1	2	TOP1 [nucleoplasm] (R-HSA-4641363) monoSUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364)	0.597	3
UniProt:P12931 SRC	6	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-SRC [plasma membrane] (R-HSA-8876922) p-Y419-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690)	0.593	6
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.589	2
UniProt:Q00987 MDM2	11	p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) MDM2 [cytosol] (R-HSA-198644) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [endocytic vesicle membrane] (R-HSA-416849) MDM2 [plasma membrane] (R-HSA-416843) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472)	0.589	2
UniProt:P22626 HNRNPA2B1	2	HNRNPA2B1 [nucleoplasm] (R-HSA-71929) HNRNPA2B1 [extracellular exosome] (R-HSA-8950304)	0.564	2
UniProt:Q3KQV3 ZNF792	1	ZNF792 [nucleoplasm] (R-HSA-3110242)	0.556	3
UniProt:Q92608 DOCK2	3	DOCK2 [specific granule lumen] (R-HSA-6799558) DOCK2 [extracellular region] (R-HSA-6806310) DOCK2 [cytosol] (R-HSA-200938)	0.556	6
UniProt:Q5D0E6 DALD3			0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	12
IntAct:EBI-16428938 CCSB ISOFORM ID			0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:Q14D33 RTP5			0.556	3
UniProt:Q6IPE9 Q6IPE9			0.556	6
UniProt:Q8WWY3 PRPF31	1	PRPF31 [nucleoplasm] (R-HSA-6806772)	0.556	6
UniProt:P29474 NOS3	9	2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane] (R-HSA-202139) 2xPalmC-MyrG-NOS3 [plasma membrane] (R-HSA-534993) 2xPalmC-MyrG-NOS3 [Golgi membrane] (R-HSA-203769) MyrG-NOS3 [cytosol] (R-HSA-203687) MyrG-NOS3 [Golgi membrane] (R-HSA-534995) NOS3 [cytosol] (R-HSA-202114) 2xPalmC-MyrG-NOS3 [endocytic vesicle membrane] (R-HSA-535007) 2xPalmC-MyrG-p-S633-NOS3 [plasma membrane] (R-HSA-9861341) 2xPalmC-MyrG-p-S1177,S1179-NOS3 [plasma membrane] (R-HSA-9860783)	0.556	3
UniProt:Q96D16 Q96D16			0.556	6
UniProt:Q13148 TADBP			0.556	3
UniProt:Q9Y272 RASD1			0.556	6
UniProt:A0A0S2Z5X4 A0A0S2Z5X4			0.556	3
IntAct:EBI-10171584 80125			0.556	3
IntAct:EBI-25865403 EHD27213144			0.556	3
UniProt:G3V1X1 G3V1X1			0.556	3
UniProt:P19404 NDUFV2	1	NDUFV2 [mitochondrial inner membrane] (R-HSA-163939)	0.556	3
UniProt:Q9UQ90 SPG7	1	SPG7 [mitochondrial inner membrane] (R-HSA-8953712)	0.556	6
UniProt:P55064 AQP5	1	AQP5 [plasma membrane] (R-HSA-431738)	0.556	3
UniProt:Q8WXH2 JPH3			0.556	3
UniProt:Q8N9J2 Q8N9J2			0.556	6
UniProt:Q9UBB4 ATX10			0.556	3
UniProt:P09172 DBH	1	DBH(40-617) [secretory granule lumen] (R-HSA-209790)	0.556	3
UniProt:P0DJD3 RBY1A			0.556	3
UniProt:Q9Y5E9 PCDBE			0.556	6
UniProt:Q9Y580 RBM7	1	RBM7 [nucleoplasm] (R-HSA-8985564)	0.553	2
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.553	2
UniProt:O75525 KHDRBS3	2	KHDRSB3 [nucleoplasm] (R-HSA-8849040) p-Y-KHDRSB3 [nucleoplasm] (R-HSA-8849035)	0.553	2
UniProt:Q14103 HNRNPD	1	HNRNPD [nucleoplasm] (R-HSA-71935)	0.547	2
UniProt:Q08211 DHX9	3	DHX9 [nucleoplasm] (R-HSA-53517) DHX9 [cytosol] (R-HSA-847700) p-DHX9 [cytosol] (R-HSA-9836168)	0.547	2
UniProt:Q8V1E7 Q8V1E7			0.543	5
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	6
UniProt:Q9NZI8 IGF2BP1	1	IGF2BP1 [cytosol] (R-HSA-428366)	0.527	2
UniProt:P35637 FUS	1	FUS [nucleoplasm] (R-HSA-72040)	0.527	2
UniProt:Q16630 CPSF6	2	CPSF6(1-490)-FGFR1(429-822) fusion [cytosol] (R-HSA-1614368) CPSF6(1-490)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838987)	0.527	2
UniProt:O14965 AURKA	6	p-T288-AURKA [cytosol] (R-HSA-2574832) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) AURKA [nucleoplasm] (R-HSA-4655443) PolyUb-AURKA [cytosol] (R-HSA-8854040) SUMO1-K258-AURKA [cytosol] (R-HSA-4655367)	0.524	2
UniProt:P26368 U2AF2	2	U2AF2 [nucleoplasm] (R-HSA-71987) 5OHK15,276-U2AF2 [nucleoplasm] (R-HSA-9630011)	0.519	2
UniProt:Q9NYB0 TERF2IP	1	TERF2IP [nucleoplasm] (R-HSA-174873)	0.508	2
UniProt:P07550 ADRB2	5	ADRB2 [plasma membrane] (R-HSA-390647) pS-ADRB2 [plasma membrane] (R-HSA-8852158) PolyUb-ADRB2 [endosome membrane] (R-HSA-6783066) ADRB2 [endosome membrane] (R-HSA-6783036) pS-ADRB2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869143)	0.508	2
UniProt:Q8AZK7 EBNA5			0.499	2
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.462	2
UniProt:Q8IUH3 RBM45			0.462	2
UniProt:O43809 NUDT21	1	NUDT21 [nucleoplasm] (R-HSA-72010)	0.462	2

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