Reactome | SUMO1-K250-HNRNPC [nucleoplasm]

SUMO1-K250-HNRNPC [nucleoplasm]

Stable Identifier

R-HSA-4570543

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Heterogeneous nuclear ribonucleoproteins C1/C2, HNRPC_HUMAN

Locations in the PathwayBrowser for interactor UniProt:O14979 HNRNPDL

Expand all

External Reference Information

External Reference

UniProt:P07910 HNRNPC

Gene Names

HNRNPC, HNRPC

Chain

initiator methionine:, chain:2-306

Reference Genes

COSMIC (genes):HNRNPC HNRNPC

dbSNP Gene:3183 HNRNPC

ENSEMBL:ENSG00000092199 HNRNPC

Participates

as an output of

RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Homo sapiens)

Other forms of this molecule

HNRNPC [nucleoplasm]

HNRNPC [cytosol]

Inferred To

hnrnpc [nucleoplasm] (Xenopus tropicalis)

SUMO1-K250-HNRNPC [nucleoplasm] (Schizosaccharomyces pombe)

Hnrnpc [nucleoplasm] (Mus musculus)

Hnrnpc [nucleoplasm] (Rattus norvegicus)

HNRNPC [nucleoplasm] (Sus scrofa)

NAB3 [nucleoplasm] (Saccharomyces cerevisiae)

HNRPC [nucleoplasm] (Bos taurus)

Modified Residues

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 250

Coordinate

250

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Interactors (102)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07910 HNRNPC	3	HNRNPC [nucleoplasm] (R-HSA-71933) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [cytosol] (R-HSA-9715136)	0.863	8
UniProt:O00505 KPNA3	2	KPNA3 [nucleoplasm] (R-HSA-1176061) KPNA3 [cytosol] (R-HSA-1176070)	0.845	7
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.834	8
UniProt:P09651 HNRNPA1	2	HNRNPA1 [nucleoplasm] (R-HSA-71927) HNRNPA1 [cytosol] (R-HSA-9727902)	0.792	5
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.749	5
UniProt:Q96IZ5 RBM41			0.742	5
UniProt:Q9UKM9 RALY			0.742	5
UniProt:Q86SE5 RALYL			0.742	7
UniProt:Q99459 CDC5L	1	CDC5L [nucleoplasm] (R-HSA-5420887)	0.731	4
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382)	0.718	6
UniProt:O00560 SDCBP	3	SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206)	0.718	6
UniProt:Q12906 ILF3	3	ILF3 [nucleoplasm] (R-HSA-9760401) ILF3 [cytosol] (R-HSA-450564) p-T188,T315-ILF3 [cytosol] (R-HSA-9836381)	0.706	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.706	18
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.675	7
UniProt:B2RXH8 HNRC2			0.666	4
UniProt:P52292 KPNA2	2	KPNA2 [cytosol] (R-HSA-205976) KPNA2 [nucleoplasm] (R-HSA-206045)	0.666	4
UniProt:O60812 HNRC1			0.666	6
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.65	3
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.643	5
UniProt:Q13435 SF3B2	1	SF3B2 [nucleoplasm] (R-HSA-71971)	0.64	3
UniProt:O60506 HNRPQ			0.615	3
UniProt:Q53F19 NCBP3			0.615	4
UniProt:Q96KR1 ZFR			0.615	3
UniProt:Q96SI9 STRBP			0.615	3
UniProt:O43390 HNRNPR	1	HNRNPR [nucleoplasm] (R-HSA-71951)	0.615	3
UniProt:P35637 FUS	1	FUS [nucleoplasm] (R-HSA-72040)	0.615	6
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.615	3
UniProt:Q8IUH3 RBM45			0.597	3
UniProt:P11387 TOP1	2	TOP1 [nucleoplasm] (R-HSA-4641363) monoSUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364)	0.597	4
UniProt:Q96QD9 FYTTD1	1	FYTTD1 [nucleoplasm] (R-HSA-8852176)	0.564	2
UniProt:Q9NQR1 KMT5A	1	SETD8 [nucleoplasm] (R-HSA-417142)	0.564	2
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.564	2
UniProt:P22626 HNRNPA2B1	2	HNRNPA2B1 [nucleoplasm] (R-HSA-71929) HNRNPA2B1 [extracellular exosome] (R-HSA-8950304)	0.564	3
UniProt:Q6ZRY4 RBPS2			0.556	3
UniProt:P78317 RNF4	2	RNF4 [nucleoplasm] (R-HSA-5684076) RNF4 [cytosol] (R-HSA-975974)	0.556	3
UniProt:Q86SE5-3 RALYL			0.556	3
UniProt:Q13148 TADBP			0.556	3
UniProt:O15131 KPNA5	2	KPNA5 [nucleoplasm] (R-HSA-1176068) KPNA5 [cytosol] (R-HSA-1176062)	0.556	3
UniProt:Q7KZS0 Q7KZS0			0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:Q53GL6 Q53GL6			0.556	3
UniProt:Q12929 EPS8	1	EPS8 [cytosol] (R-HSA-9662382)	0.556	3
UniProt:P25791 LMO2	1	LMO2 [nucleoplasm] (R-HSA-8956513)	0.556	3
UniProt:Q68DK2-5 ZFYVE26			0.556	3
UniProt:Q9NRI5-2 DISC1			0.556	3
IntAct:EBI-10178797 4005			0.556	3
UniProt:P38340 NTM1			0.556	3
UniProt:G2XKQ0 SUMO5			0.556	3
UniProt:P26367 PAX6	1	PAX6 [nucleoplasm] (R-HSA-3009044)	0.556	3
UniProt:Q14103 HNRNPD	1	HNRNPD [nucleoplasm] (R-HSA-71935)	0.547	3
UniProt:Q9UHX1 PUF60	1	PUF60 [nucleoplasm] (R-HSA-8865910)	0.536	2
UniProt:Q9NQZ2 UTP3	1	UTP3 [nucleoplasm] (R-HSA-6790637)	0.536	3
UniProt:Q9Y618 NCOR2	2	NCOR2 [nucleoplasm] (R-HSA-442469) monoSUMO1-K672-NCOR2 [nucleoplasm] (R-HSA-3927904)	0.536	2
UniProt:Q92917 GPKOW	1	GPKOW [nucleoplasm] (R-HSA-8850839)	0.536	3
UniProt:P14866 HNRNPL	1	HNRNPL [nucleoplasm] (R-HSA-71947)	0.527	3
UniProt:P09234 SNRPC	1	SNRPC [nucleoplasm] (R-HSA-8865876)	0.527	2
UniProt:P49761 CLK3			0.527	2
UniProt:Q9NZB2 F120A			0.527	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	4
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.527	2
UniProt:P38919 EIF4A3	2	EIF4A3 [nucleoplasm] (R-HSA-8849149) EIF4A3 [cytosol] (R-HSA-927868)	0.527	2
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	3
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.527	2
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.525	2
UniProt:Q92879 CELF1			0.519	2
UniProt:Q9BYB0 SHANK3	1	SHANK3 [cytosol] (R-HSA-6794277)	0.508	2
UniProt:Q9NYF8 BCLF1			0.483	2
UniProt:Q8WXF1 PSPC1			0.483	2
UniProt:P52294 KPNA1	2	KPNA1 [cytosol] (R-HSA-180612) KPNA1 [nucleoplasm] (R-HSA-188865)	0.483	2
UniProt:Q13151 HNRNPA0	1	HNRNPA0 [nucleoplasm] (R-HSA-71925)	0.483	2
UniProt:Q07666 KHDRBS1	3	p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm] (R-HSA-8848970) p-Y435,Y440,Y443-KHDRBS1 [cytosol] (R-HSA-8848995) KHDRBS1 [nucleoplasm] (R-HSA-8848941)	0.483	2
UniProt:Q1KMD3 HNRL2			0.483	2
UniProt:Q8IX01 SUGP2			0.483	2
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.483	2
UniProt:Q8NEY8 PPHLN1	1	PPHLN1 [nucleoplasm] (R-HSA-9844032)	0.483	2
UniProt:Q86VM9 ZCH18			0.483	6
UniProt:Q9BQ04 RBM4B			0.483	2
UniProt:Q9BZJ0 CRNKL1	1	CRNKL1 [nucleoplasm] (R-HSA-8867899)	0.483	2
UniProt:Q13595 TRA2A			0.483	2
UniProt:Q14151 SAFB2			0.483	2
UniProt:Q9NW64 RBM22	1	RBM22 [nucleoplasm] (R-HSA-5215975)	0.483	2
UniProt:O15226 NKRF			0.483	2
UniProt:O15504 NUP42	1	NUPL2 [cytosol] (R-HSA-157697)	0.483	2
UniProt:Q9NUL3 STAU2			0.483	2
UniProt:Q15003 NCAPH	3	p-T-NCAPH [cytosol] (R-HSA-2517885) NCAPH [cytosol] (R-HSA-1638139) p-S570-NCAPH [cytosol] (R-HSA-2529017)	0.483	2
UniProt:P09012 SNRPA	1	SNRPA [nucleoplasm] (R-HSA-71915)	0.483	2
UniProt:Q96DF8 ESS2			0.483	2
UniProt:Q6PJT7 ZC3HE			0.483	2
UniProt:Q15459 SF3A1	1	SF3A1 [nucleoplasm] (R-HSA-71962)	0.483	2
UniProt:Q9H307 PNN	1	PNN [nucleoplasm] (R-HSA-9770779)	0.483	2
UniProt:O95758 PTBP3			0.483	2
UniProt:O75533 SF3B1	1	SF3B1 [nucleoplasm] (R-HSA-71968)	0.483	2
UniProt:Q13285 NR5A1	3	NR5A1 [nucleoplasm] (R-HSA-452955) polySUMO2-K119,K194-NR5A1 [nucleoplasm] (R-HSA-4546383) monoSUMO1-K119,K194-NR5A1 [nucleoplasm] (R-HSA-4546382)	0.483	2
UniProt:Q9HCK8 CHD8	1	CHD8 [nucleoplasm] (R-HSA-3221598)	0.483	2
UniProt:Q9Y2W1 THRAP3	1	THRAP3 [nucleoplasm] (R-HSA-8932115)	0.483	2
UniProt:Q9Y6M1 IGF2BP2	1	IGF2BP2 [cytosol] (R-HSA-428302)	0.483	2
UniProt:O14979 HNRNPDL	1	HNRNPDL [cytosol] (R-HSA-8950323)	0.483	2
UniProt:Q14562 DHX8	1	DHX8 [nucleoplasm] (R-HSA-5688092)	0.483	2
UniProt:O75152 ZC3H11A	1	ZC3H11A [nucleoplasm] (R-HSA-8850659)	0.483	2
UniProt:P17844 DDX5	4	DDX5 [nucleoplasm] (R-HSA-3900136) DDX5 [cytosol] (R-HSA-9682643) polySUMO2-K53-DDX5 [nucleoplasm] (R-HSA-3900186) monoSUMO1-K53-DDX5 [nucleoplasm] (R-HSA-3900041)	0.483	2
UniProt:Q2TBE0 CWF19L2	1	CWF19L2 [nucleoplasm] (R-HSA-9770846)	0.483	2
UniProt:Q14974 KPNB1	5	KPNB1 [cytosol] (R-HSA-180733) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [specific granule lumen] (R-HSA-6799646) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978)	0.483	2

Cite Us!