SUMOylation of MDC1 with SUMO1

Stable Identifier
R-HSA-4570554
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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MDC1 is SUMOylated at lysine-1840 with SUMO1. SUMOyation of MDC1 is required for its degradation, which is thought to be directed by ubiquitinylation by RNF4 (Luo et al. 2012).
Literature References
PubMed ID Title Journal Year
22635276 Sumoylation of MDC1 is important for proper DNA damage response

Lou, Z, Yuan, J, Luo, K, Wang, L, Zhang, H

EMBO J. 2012
Participants
Participates
Catalyst Activity

SUMO transferase activity of SUMO1:C93-UBE2I [cytoplasm]

Orthologous Events
Authored
Reviewed
Created
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