SMURF1/2 ubiquitinates PRICKLE1

Stable Identifier
Reaction [transition]
Homo sapiens
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PRICKLE1 is a conserved PCP protein with a localization pattern opposite to that of DVL. PRICKLE1 is recruited to the PARD6A:ppDVL2:SMURF complex through its interaction with DVL and is subsequently ubiquitinated by the E3 ligase activity of SMURF (Narimatsu et al, 2009; Jenny et al, 2005). This leads to localized degradation of PRICKLE1, contributing to its asymmetrical localization (Narimatsu et al, 2009). Note that in this reaction the interaction between PRICKLE1 and DVL is not shown.

Literature References
PubMed ID Title Journal Year
15937478 Diego and Prickle regulate Frizzled planar cell polarity signalling by competing for Dishevelled binding

Burnett, M, Reynolds-Kenneally, J, Das, G, Jenny, A, Mlodzik, M

Nat Cell Biol 2005
19379695 Regulation of planar cell polarity by Smurf ubiquitin ligases

Luga, V, Wrana, JL, Miller, B, Roncari, L, Sakuma, R, Bose, R, Ching, P, Attisano, L, Zhang, L, Pye, M, Narimatsu, M

Cell 2009
Catalyst Activity

ubiquitin protein ligase activity of PARD6A:pp-DVL2:SMURF [plasma membrane]

Orthologous Events
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