SCRIB is required for asymmetric membrane localization of VANGL2

Stable Identifier
Reaction [binding]
Homo sapiens
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VANGL2 is a core PCP protein. In Drosophila, asymmetric localization of Stbm (the fly VANGL homologue) and Fz to opposite membranes is a hallmark of the establishment of planar cell polarity (reviewed in Maung and Jenny, 2011). In the mouse inner-ear sensory hair cells, VANGL2 is also asymmetrically distributed in the membrane (Montcouquiol et al, 2003, 2006), and this distribution depends on a direct interaction with SCRIB, a peripheral membrane protein with no known role in fly PCP (reviewed in May-Simera and Kelley, 2012). Asymmetric VANGL2 localization in the mouse inner ear also depends on CELSR1, homologue to the Drosophila core PCP protein Flamingo, however a direct interaction between VANGL2 and CELSR1 has not been demonstrated (Montcouquiol et al, 2006).

Literature References
PubMed ID Title Journal Year
16687519 Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals

Forge, A, Dickman, JD, Copeland, NG, Kelley, MW, Wenthold, RJ, Warchol, ME, Kach, J, Huss, D, Jenkins, NA, Sans, N, Bogani, D, Montcouquiol, M, Rachel, RA, Murdoch, J

J. Neurosci. 2006
21983142 Planar cell polarity in Drosophila

Maung, SM, Jenny, A

Organogenesis 2011
12724779 Identification of Vangl2 and Scrb1 as planar polarity genes in mammals

Montcouquiol, M, Copeland, NG, Kelley, MW, Lanford, PJ, Rachel, RA, Jenkins, NA

Nature 2003
23140627 Planar cell polarity in the inner ear

May-Simera, H, Kelley, MW

Curr. Top. Dev. Biol. 2012
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