PIAS1 SUMOylates SATB1 with SUMO2,3

Stable Identifier
R-HSA-4615839
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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PIAS1 SUMOylates SATB1 at lysine-744 with SUMO2,3 (Tan et al. 2008, Tan et al. 2010, Tammsalu et al. 2014). SUMOylation targets SATB1 to PML bodies where it is cleaved by caspase.
Literature References
PubMed ID Title Journal Year
20351170 Phosphorylation-dependent interaction of SATB1 and PIAS1 directs SUMO-regulated caspase cleavage of SATB1

Chen, Y, Song, J, Durrin, LK, Tan, JA

Mol. Cell. Biol. 2010
24782567 Proteome-wide identification of SUMO2 modification sites

Tatham, MH, Hay, RT, Tammsalu, T, Ibrahim, AF, Jaffray, EG, Matic, I

Sci Signal 2014
18408014 SUMO conjugation to the matrix attachment region-binding protein, special AT-rich sequence-binding protein-1 (SATB1), targets SATB1 to promyelocytic nuclear bodies where it undergoes caspase cleavage

Chen, Y, Sun, Y, Krontiris, TG, Song, J, Durrin, LK, Tan, JA

J. Biol. Chem. 2008
Participants
Participates
Catalyst Activity

SUMO transferase activity of PIAS1 [nucleoplasm]

Orthologous Events
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