PIAS2-2 SUMOylates SUZ12 with SUMO1

Stable Identifier
R-HSA-4615873
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
PIAS2-2 (PIASxbeta) SUMOylates SUZ12, a subunit of the Polycomb Repressive Complex 2 (PRC2), at lysine-75 with SUMO1 (Riising et al. 2008). SUMOyation does not affect the repression of transcription by PRC2. The effect of SUMOylation on PRC2 function is unknown. The EZH2 subunit of PRC2 can also be SUMOylated at multiple positions.
Literature References
PubMed ID Title Journal Year
18628979 The polycomb repressive complex 2 is a potential target of SUMO modifications

Helin, K, Chiocca, S, Boggio, R, Riising, EM, Pasini, D

PLoS ONE 2008
Participants
Participates
Catalyst Activity

SUMO transferase activity of PIAS2-2 [nucleoplasm]

Orthologous Events
Authored
Reviewed
Created
Cite Us!