SUMOylation of CBX5 with SUMO1

Stable Identifier
R-HSA-4615933
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SUMOylation of CBX5 with SUMO1
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As inferred from mouse homologs, CBX5 (HP1 alpha) is SUMOylated at lysine-84 and other lysine residues with SUMO1. SUMOylated CBX5 associates with long non-coding transcripts in pericentric heterochromatin and SUMOylation is required for initial targeting of CBX5 to pericentric domains.
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Catalyst Activity

SUMO transferase activity of SUMO1:C93-UBE2I [cytoplasm]

Physical Entity
SUMO1:C93-UBE2I [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Inferred From
Sumoylation of Cbx5 with Sumo1 (Mus musculus)
Authored
May, B  (2013-09-21)
Reviewed
Matunis, MJ  (2017-01-22)
Yang, WC  (2017-01-22)
Lu, J  (2017-01-22)
Created
May, B  (2013-09-27)
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