RANBP2 SUMOylates HDAC4 with SUMO2,3

Stable Identifier
R-HSA-4615987
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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RANBP2 SUMOylates HDAC4 at lysine-559 with SUMO2,3 (Kirsh et al. 2002). SUMOylation increases transcription repression by HDAC4.

Literature References
PubMed ID Title Journal Year
12032081 The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase

Kirsh, O, Seeler, JS, Pichler, A, Gast, A, Müller, S, Miska, E, Mathieu, M, Harel-Bellan, A, Kouzarides, T, Melchior, F, Dejean, A

EMBO J. 2002
Participants
Participates
Catalyst Activity

SUMO transferase activity of Nuclear Pore Complex (NPC) [nuclear envelope]

Orthologous Events
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