Reactome | SYMPK [nucleoplasm]

SYMPK [nucleoplasm]

Stable Identifier

R-HSA-4615988

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Symplekin, SYMPK_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA Polymerase II Transcription Termination (Homo sapiens)
    - Cleavage of Intronless Pre-mRNA at 3'-end (Homo sapiens)
      - intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
        
        CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        SYMPK [nucleoplasm] (Homo sapiens)
      - upstream mRNA fragment:CPSF:PAP:PABPN1 complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        SYMPK [nucleoplasm] (Homo sapiens)
    - Cleavage of mRNA at the 3'-end (Homo sapiens)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        SYMPK [nucleoplasm] (Homo sapiens)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        SYMPK [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q92797 SYMPK

Gene Names

SYMPK, SPK

Chain

chain:1-1274

Reference Genes

BioGPS Gene:8189 Q927972

COSMIC (genes):SYMPK SYMPK

CTD Gene:8189 Q927972

dbSNP Gene:8189 Q927972

ENSEMBL:ENSG00000125755 SYMPK

HGNC:22935 Q927972

KEGG:hsa:8189 Q927972

Monarch:8189 Q927972

NCBI Gene:8189 Q927972

OMIM:602388 Q927972

UCSC:Q92797 Q927972

Reference Transcript

Participates

as a component of

CPSF [nucleoplasm] (Homo sapiens)

Inferred To

pta1 [nucleoplasm] (Schizosaccharomyces pombe)

Sympk [nucleoplasm] (Mus musculus)

Sympk [nucleoplasm] (Rattus norvegicus)

SYMPK [nucleoplasm] (Bos taurus)

SYMPK [nucleoplasm] (Canis familiaris)

SYMPK [nucleoplasm] (Sus scrofa)

PTA1 [nucleoplasm] (Saccharomyces cerevisiae)

sympk [nucleoplasm] (Dictyostelium discoideum)

symk-1 [nucleoplasm] (Caenorhabditis elegans)

Sym [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of SYMPK [nucleoplasm] (Danio rerio)

Ghost homologue of SYMPK [nucleoplasm] (Gallus gallus)

Ghost homologue of SYMPK [nucleoplasm] (Xenopus tropicalis)

Cross References

ENSEMBL

ENST00000245934, ENSP00000245934, ENSG00000125755

OpenTargets

ENSG00000125755

GeneCards

SYMPK

HPA

ENSG00000125755-SYMPK

PRO

Q92797

Pharos - Targets

Q92797

GlyGen

Q92797

PDB

3O2S, 6V4X, 4H3K, 3ODS, 3O2Q, 3ODR, 4H3H, 3O2T

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35613 BSG	2	BSG [plasma membrane] (R-HSA-197673) BSG [Golgi membrane] (R-HSA-204478)	0.564	2
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:O95639 CPSF4	1	CPSF4 [nucleoplasm] (R-HSA-169104)	0.527	3