SUMOylation of HDAC2 with SUMO1

Stable Identifier
R-HSA-4616015
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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HDAC2 is SUMOylated at lysine-462 with SUMO1 (Brandl et al. 2012). SUMOylation of HDAC2 blocks TP53-dependent (p53-dependent) expression of genes but is required for induction of NF-kB-dependent gene expression (Wagner et al. 2015).
Literature References
PubMed ID Title Journal Year
22493095 Dynamically regulated sumoylation of HDAC2 controls p53 deacetylation and restricts apoptosis following genotoxic stress

Schneider, G, Knauer, SK, Heinzel, T, Stauber, RH, Wagner, T, Melchior, F, Krämer, OH, Uhlig, KM, Brandl, A

J Mol Cell Biol 2012
25704882 Sumoylation of HDAC2 promotes NF-κB-dependent gene expression

Hemmerich, P, Schneider, G, Knauer, SK, Heinzel, T, Dannenberg, JH, Wagner, T, Krämer, OH, Wolff, K, Brandl, A, Kiweler, N

Oncotarget 2015
Participants
Participates
Catalyst Activity

SUMO transferase activity of SUMO1:C93-UBE2I [cytoplasm]

Orthologous Events
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