Reactome | polySUMO2,3-K559-HDAC4 [nucleoplasm]

polySUMO2,3-K559-HDAC4 [nucleoplasm]

Stable Identifier

R-HSA-4616029

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

HDAC4_HUMAN, Histone deacetylase 4

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
12032081	The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase Dejean, A, Mathieu, M, Müller, S, Seeler, JS, Gast, A, Kirsh, O, Harel-Bellan, A, Melchior, F, Kouzarides, T, Pichler, A, Miska, E	EMBO J.	2002

External Reference Information

External Reference

UniProt:P56524 HDAC4

Gene Names

HDAC4, KIAA0288

Chain

chain:1-1084

Reference Genes

COSMIC (genes):HDAC4 HDAC4

dbSNP Gene:9759 HDAC4

ENSEMBL:ENSG00000068024 HDAC4

Participates

as an output of

RANBP2 SUMOylates HDAC4 with SUMO2,3 (Homo sapiens)

Other forms of this molecule

monoSUMO1-K559-HDAC4 [nucleoplasm]

HDAC4 [nucleoplasm]

Inferred To

hdaD [nucleoplasm] (Dictyostelium discoideum)

Homologues of polySUMO2,3-K559-HDAC4 [nucleoplasm] (Dictyostelium discoideum)

Homologues of polySUMO2,3-K559-HDAC4 [nucleoplasm] (Plasmodium falciparum)

polySUMO2,3-K559-HDAC4 [nucleoplasm] (Bos taurus)

polySUMO2,3-K559-HDAC4 [nucleoplasm] (Dictyostelium discoideum)

polySUMO2,3-K559-HDAC4 [nucleoplasm] (Drosophila melanogaster)

polySUMO2,3-K559-HDAC4 [nucleoplasm] (Gallus gallus)

polySUMO2,3-K559-HDAC4 [nucleoplasm] (Mus musculus)

polySUMO2,3-K559-HDAC4 [nucleoplasm] (Plasmodium falciparum)

polySUMO2,3-K559-HDAC4 [nucleoplasm] (Rattus norvegicus)

polySUMO2,3-K559-HDAC4 [nucleoplasm] (Sus scrofa)

Modified Residues

Name

sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 559

Coordinate

559

Modification

polySUMO2,3 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Interactors (32)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.947	15
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.899	9
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.886	10
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.865	9
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.783	8
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.774	6
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.774	6
UniProt:P56524 HDAC4	3	polySUMO2,3-K559-HDAC4 [nucleoplasm] (R-HSA-4616029) monoSUMO1-K559-HDAC4 [nucleoplasm] (R-HSA-4616016) HDAC4 [nucleoplasm] (R-HSA-351581)	0.655	4
UniProt:Q8AZK7 EBNA5			0.612	5
UniProt:A9UHW6 MI4GD			0.602	4
UniProt:Q13761 RUNX3	7	PolyUb-RUNX3 [nucleoplasm] (R-HSA-8952417) p-Y-RUNX3 [cytosol] (R-HSA-8937805) PolyUb-K94,K148-RUNX3 [nucleoplasm] (R-HSA-8952387) PolyUb-K94,K148-RUNX3 [cytosol] (R-HSA-8952400) Ac-K94,K171-RUNX3 [nucleoplasm] (R-HSA-8951965) RUNX3 [cytosol] (R-HSA-8937797) RUNX3 [nucleoplasm] (R-HSA-8865393)	0.558	9
UniProt:Q01850 CDR2			0.556	3
UniProt:O95967 EFEMP2	1	EFEMP2 [extracellular region] (R-HSA-2161231)	0.556	3
UniProt:Q9H9E1 ANRA2			0.556	3
UniProt:Q8ND90 PNMA1			0.556	3
UniProt:Q6NUQ1 RINT1	1	RINT1 [cytosol] (R-HSA-6810991)	0.556	3
UniProt:Q96JN2-2 CCDC136			0.556	3
UniProt:O95751 LDOC1			0.556	3
UniProt:Q5JR59 MTUS2			0.556	3
UniProt:O76015 KRT38	1	KRT38 [cytosol] (R-HSA-6809615)	0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:P10275 AR	4	AR [cytosol] (R-HSA-5618082) AR [nucleoplasm] (R-HSA-446174) monoSUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) PolyUb-AR [nucleoplasm] (R-HSA-6782984)	0.544	4
UniProt:O75376 NCOR1	2	NCOR1 [cytosol] (R-HSA-1253310) NCOR1 [nucleoplasm] (R-HSA-442501)	0.527	2
UniProt:O15379 HDAC3	2	HDAC3 [nucleoplasm] (R-HSA-442464) Unfolded HDAC3 [cytosol] (R-HSA-6813777)	0.527	2
UniProt:Q9HCU9 BRMS1	1	BRMS1 [nucleoplasm] (R-HSA-4650034)	0.524	2
UniProt:P08393 ICP0			0.524	3
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [nucleoplasm] (R-HSA-912481) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) UBE2I [cytosol] (R-HSA-4655342)	0.508	3
UniProt:P41182 BCL6	1	BCL6 [nucleoplasm] (R-HSA-5223066)	0.499	3
UniProt:Q06413 MEF2C	3	MEF2C [nucleoplasm] (R-HSA-199938) p-S396-MEF2C [nucleoplasm] (R-HSA-199942) p-T293,T300,S387-MEF2C [nucleoplasm] (R-HSA-448838)	0.491	2
UniProt:Q02078 MEF2A	3	p-T312,T319-MEF2A [nucleoplasm] (R-HSA-448834) p-S408-MEF2A [nucleoplasm] (R-HSA-199909) MEF2A [nucleoplasm] (R-HSA-199903)	0.489	2

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