ZNRF3 autoubiquitinates to promote its internalization

Stable Identifier
R-HSA-4641246
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Mutation of the RING domain of ZNRF3 abrogates membrane clearance of the ubiquitin ligase, suggesting that its internalization depends on auto-ubiquitination (Hao et al, 2012).
Literature References
PubMed ID Title Journal Year
22575959 ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

Mickanin, C, Zhang, Y, Bouwmeester, T, Zamponi, R, Xie, Y, Liu, D, Charlat, O, Kirschner, MW, Cong, F, Porter, JA, Avello, M, Lei, H, Serluca, FC, Finan, PM, Oster, E, Hao, HX, Ma, Q, Ruffner, H, Mao, X

Nature 2012
Participants
Participates
Catalyst Activity

ubiquitin protein ligase activity of RSPO:LGR:ZNRF3,RNF43 [plasma membrane]

Orthologous Events
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