Ubiquitinated DVL1 is degraded by the proteasome

Stable Identifier
R-HSA-4641260
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Ubiquitinated DVL1 is degraded by the proteasome
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After ubiquitination by HECW1, DVL1 is degraded by the proteasome.

Literature References
PubMed ID Title Journal Year
14684739 NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1

Miyazaki, K, Aoki, M, Itoyama, Y, Ozaki, T, Goto, T, Kurose, Y, Fujita, T, Kato, S, Kato, C, Nakagawara, A, Sakamoto, M

J. Biol. Chem. 2004
Participants
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Output
Participates
as an event of
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Physical Entity
26S proteasome [cytosol] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Orthologous Events
Ubiquitinated DVL1 is degraded by the proteasome (Bos taurus)
Ubiquitinated DVL1 is degraded by the proteasome (Caenorhabditis elegans)
Ubiquitinated DVL1 is degraded by the proteasome (Canis familiaris)
Ubiquitinated DVL1 is degraded by the proteasome (Danio rerio)
Ubiquitinated DVL1 is degraded by the proteasome (Drosophila melanogaster)
Ubiquitinated DVL1 is degraded by the proteasome (Mus musculus)
Ubiquitinated DVL1 is degraded by the proteasome (Rattus norvegicus)
Ubiquitinated DVL1 is degraded by the proteasome (Sus scrofa)
Authored
Rothfels, K  (2013-09-23)
Reviewed
Rajakulendran, N  (2014-01-22)
van Amerongen, R  (2014-02-15)
Kikuchi, A  (2014-04-22)
Created
Rothfels, K  (2013-09-28)
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