Reactome | polySUMO2,3-TOP2A [nucleoplasm]

polySUMO2,3-TOP2A [nucleoplasm]

Stable Identifier

R-HSA-4641298

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DNA topoisomerase 2-alpha ecNumber5.99.1.3/ecNumber, TOP2A_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P13010 XRCC5

Expand all

Literature References

PubMed ID	Title	Journal	Year
18394993	Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha van Deursen, JM, Shuai, K, Kao, E, Jeganathan, KB, Tahk, S, Malureanu, L, Dawlaty, MM, Sustmann, C, Grosschedl, R	Cell	2008
18381449	Conjugation of human topoisomerase 2 alpha with small ubiquitin-like modifiers 2/3 in response to topoisomerase inhibitors: cell cycle stage and chromosome domain specificity Rino, J, Santos, V, Pinheiro, I, Hay, RT, Jaffray, E, Costa, R, Ferreira, F, Cardoso, J, Ferreira, J, Agostinho, M	Cancer Res.	2008
24782567	Proteome-wide identification of SUMO2 modification sites Tatham, MH, Hay, RT, Tammsalu, T, Ibrahim, AF, Jaffray, EG, Matic, I	Sci Signal	2014
25114211	Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli Impens, F, Cossart, P, Radoshevich, L, Ribet, D	Proc. Natl. Acad. Sci. U.S.A.	2014

External Reference Information

External Reference

UniProt:P11388 TOP2A

Gene Names

TOP2A, TOP2

Chain

chain:1-1531

Reference Genes

BioGPS Gene:7153 TOP2A

COSMIC (genes):TOP2A TOP2A

CTD Gene:7153 TOP2A

dbSNP Gene:7153 TOP2A

ENSEMBL:ENSG00000131747 TOP2A

ENSEMBL_homo_sapiens_GENE:ENSG00000131747.15 TOP2A

HGNC:11989 TOP2A

KEGG Gene (Homo sapiens):7153 TOP2A

Monarch:7153 TOP2A

NCBI Gene:7153 TOP2A

OMIM:126430 TOP2A

UCSC:P11388 TOP2A

Reference Transcript

RefSeq:NM_001067.3 TOP2A

Other Identifiers

11720970_at

11720971_at

11720972_at

1592_at

16844312

201291_PM_s_at

201291_s_at

201292_PM_at

201292_at

3756157

3756194

3756195

3756196

3756197

3756198

3756199

3756200

3756201

3756202

3756203

3756204

3756205

3756206

3756207

3756208

3756209

3756210

3756211

3756212

3756213

3756214

3756215

3756216

3756217

3756218

3756219

3756220

3756221

3756222

3756223

3756224

3756225

3756226

3756227

3756228

3756229

3756230

3756231

3756232

3756233

3756234

3756235

40145_at

7153

74096_at

8014974

904_s_at

A_23_P118834

GE57498

GO:0000166

GO:0000228

GO:0000287

GO:0000712

GO:0000775

GO:0000793

GO:0000819

GO:0001673

GO:0002244

GO:0003677

GO:0003682

GO:0003723

GO:0003824

GO:0003916

GO:0003918

GO:0005080

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005814

GO:0005815

GO:0005856

GO:0006259

GO:0006265

GO:0006266

GO:0006310

GO:0006351

GO:0006355

GO:0006974

GO:0007059

GO:0007143

GO:0008094

GO:0008301

GO:0009330

GO:0012501

GO:0016853

GO:0022414

GO:0030154

GO:0030261

GO:0030263

GO:0032991

GO:0040016

GO:0042752

GO:0042803

GO:0043065

GO:0043130

GO:0043226

GO:0045870

GO:0045944

GO:0046872

GO:0046982

GO:0048511

GO:0048856

GO:0140013

GO:0140097

GO:0140657

GO:1905463

GO:1990904

HMNXSV003030322

Hs.156346.0.S1_3p_a_at

Hs.156346.0.S3_3p_at

ILMN_1686097

J04088_at

L47276_s_at

PH_hs_0009437

TC17001462.hg

TC17002618.hg

Participates

as an output of

PIAS4 SUMOylates TOP2A with SUMO2,3 (Homo sapiens)

Other forms of this molecule

TOP2A [nucleoplasm]

monoSUMO1-K-TOP2A [nucleoplasm]

Inferred To

top2a [nucleoplasm] (Xenopus tropicalis)

TOP2A [nucleoplasm] (Bos taurus)

polySUMO2,3-TOP2A [nucleoplasm] (Dictyostelium discoideum)

polySUMO2,3-TOP2A [nucleoplasm] (Drosophila melanogaster)

polySUMO2,3-TOP2A [nucleoplasm] (Gallus gallus)

polySUMO2,3-TOP2A [nucleoplasm] (Mus musculus)

polySUMO2,3-TOP2A [nucleoplasm] (Plasmodium falciparum)

polySUMO2,3-TOP2A [nucleoplasm] (Rattus norvegicus)

polySUMO2,3-TOP2A [nucleoplasm] (Sus scrofa)

Modified Residues

Name

sumoylated lysine (polySUMO2,3 [nucleoplasm]) at unknown position

Modification

polySUMO2,3 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_001058.2

ZINC - World Drugs

TOP2A_HUMAN

Guide to Pharmacology - Targets

2637

OpenTargets

ENSG00000131747

ZINC - FDA approved

TOP2A_HUMAN

ZINC - Substances

TOP2A_HUMAN

ZINC target

P11388

ZINC - Biogenic

TOP2A_HUMAN

PRO

P11388

PDB

5NNE, 5GWK, 6ZY7, 6ZY8, 1ZXN, 6ZY5, 4R1F, 6ZY6, 1ZXM, 4FM9

ZINC - Metabolites

TOP2A_HUMAN

GeneCards

P11388

HPA

ENSG00000131747-TOP2A

Ensembl

ENSG00000131747, ENST00000423485, ENSP00000411532

Pharos - Targets

P11388

ZINC - Predictions - Purchasable

TOP2A_HUMAN

HMDB Protein

HMDBP10697

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q05655 PRKCD	12	PRKCD(1-676) [nucleoplasm] (R-HSA-450606) PRKCD(330-676) [extracellular region] (R-HSA-6806199) PRKCD(1-329) [extracellular region] (R-HSA-6806226) PRKCD(1-329) [azurophil granule lumen] (R-HSA-6799219) PRKCD(330-676) [azurophil granule lumen] (R-HSA-6799221) p-T507-PRKCD [cytosol] (R-HSA-5218746) p-T507,S645,S664-PRKCD [cytosol] (R-HSA-5218734) active p-T507,S645,S664-PRKCD [plasma membrane] (R-HSA-5607635) p-T507,S645,S664-PRKCD(1-676) [plasma membrane] (R-HSA-198294) PRKCD(330-676) [cytosol] (R-HSA-212551) PRKCD(1-329) [cytosol] (R-HSA-212547) PRKCD [cytosol] (R-HSA-58200)	0.679	10
UniProt:P13010 XRCC5	4	XRCC5 [extracellular region] (R-HSA-6806530) XRCC5 [secretory granule lumen] (R-HSA-6801297) XRCC5 [cytosol] (R-HSA-3134849) XRCC5 [nucleoplasm] (R-HSA-58274)	0.597	3
UniProt:P09874 PARP1	4	polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) PARP1 [nucleoplasm] (R-HSA-201568)	0.597	4
UniProt:P78527 PRKDC	4	K48polyUb-PRKDC [cytosol] (R-HSA-8938766) PRKDC [cytosol] (R-HSA-3134816) p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-HSA-76302) PRKDC [nucleoplasm] (R-HSA-62161)	0.597	3
UniProt:P11387 TOP1	2	monoSUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364) TOP1 [nucleoplasm] (R-HSA-4641363)	0.597	4
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.57	5
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.564	3
UniProt:P36578 RPL4	1	RPL4 [cytosol] (R-HSA-72474)	0.527	2
UniProt:P61313 RPL15	1	RPL15 [cytosol] (R-HSA-72416)	0.527	2
UniProt:Q9Y4E5 ZN451			0.527	2
UniProt:P27635 RPL10	1	RPL10 [cytosol] (R-HSA-72402)	0.527	2
UniProt:Q9UN86 G3BP2	1	G3BP2 [cytosol] (R-HSA-9729507)	0.527	2
UniProt:P38398 BRCA1	20	polySUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) monoSUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) BRCA1 M1411T [nucleoplasm] (R-HSA-9702140) BRCA1 M1400V [nucleoplasm] (R-HSA-9701202) BRCA1 L1407P [nucleoplasm] (R-HSA-9702135) BRCA1 Y777* [nucleoplasm] (R-HSA-9702765) BRCA1 S1009* [nucleoplasm] (R-HSA-9702755) BRCA1 P724Lfs12 [nucleoplasm] (R-HSA-9703778) BRCA1 S451 [nucleoplasm] (R-HSA-9702754) BRCA1 S864* [nucleoplasm] (R-HSA-9702752) BRCA1 P897Kfs5 [nucleoplasm] (R-HSA-9703782) BRCA1 N555Kfs17 [nucleoplasm] (R-HSA-9703781) BRCA1 Y1127Sfs6 [nucleoplasm] (R-HSA-9703780) BRCA1 S886Cfs16 [nucleoplasm] (R-HSA-9703802) BRCA1 V83Cfs2 [nucleoplasm] (R-HSA-9703800) BRCA1 T464Pfs11 [nucleoplasm] (R-HSA-9703807) BRCA1 G813Dfs2 [nucleoplasm] (R-HSA-9703549) BRCA1 V340Gfs6 [nucleoplasm] (R-HSA-9703804) BRCA1 Y655* [nucleoplasm] (R-HSA-9702769) BRCA1 W372* [nucleoplasm] (R-HSA-9702768)	0.524	3
UniProt:O14497-1 ARID1A			0.499	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	8
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.483	2
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2
UniProt:P42768 WAS	2	WAS [cytosol] (R-HSA-201879) p-Y291-WAS [cytosol] (R-HSA-2197668)	0.462	2

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