Reactome | SUMOylation of TOP1 with SUMO1

SUMOylation of TOP1 with SUMO1

Stable Identifier

R-HSA-4641362

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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TOP1 is SUMOylated at lysine-117 with SUMO1 (Mao et al. 2000, Mo et al. 2002, Rallabhandi et al. 2002, Impens et al. 2014). SUMOylation is observed in response to the topoisomerase inhibitor camptothecin and causes nucleolar delocalization of TOP1.

Literature References

PubMed ID	Title	Journal	Year
10759568	SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage Mao, Y, Sun, M, Desai, SD, Liu, LF	Proc. Natl. Acad. Sci. U.S.A.	2000
12149243	Sumoylation of topoisomerase I is involved in its partitioning between nucleoli and nucleoplasm and its clearing from nucleoli in response to camptothecin Rallabhandi, P, Hashimoto, K, Mo, YY, Beck, WT, Moitra, PK, D'Arpa, P	J. Biol. Chem.	2002
11709553	Nucleolar delocalization of human topoisomerase I in response to topotecan correlates with sumoylation of the protein Mo, YY, Yu, Y, Shen, Z, Beck, WT	J. Biol. Chem.	2002
25114211	Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli Impens, F, Radoshevich, L, Cossart, P, Ribet, D	Proc. Natl. Acad. Sci. U.S.A.	2014