Reactome | TOP1 [nucleoplasm]

TOP1 [nucleoplasm]

Stable Identifier

R-HSA-4641363

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DNA topoisomerase 1 ecNumber5.99.1.2/ecNumber, TOP1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P13010 XRCC5

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of DNA replication proteins (Homo sapiens)
        
        SUMOylation of TOP1 with SUMO1 (Homo sapiens)
        
        TOP1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P11387 TOP1

Gene Names

TOP1

Chain

initiator methionine:, chain:2-765

Reference Genes

BioGPS Gene:7150 TOP1

COSMIC (genes):TOP1 TOP1

CTD Gene:7150 TOP1

dbSNP Gene:7150 TOP1

ENSEMBL:ENSG00000198900 TOP1

ENSEMBL_homo_sapiens_GENE:ENSG00000198900.7 TOP1

HGNC:11986 TOP1

KEGG Gene (Homo sapiens):7150 TOP1

Monarch:7150 TOP1

NCBI Gene:7150 TOP1

OMIM:126420 TOP1

UCSC:P11387 TOP1

Reference Transcript

RefSeq:NM_003286.3 TOP1

Other Identifiers

1030_s_at

11717437_x_at

11717438_x_at

11717439_s_at

16913737

1710_s_at

208900_PM_s_at

208900_s_at

208901_PM_s_at

208901_s_at

2367108

2367109

2367112

2367113

31680_at

3885463

3885465

3885466

3885467

3885468

3885469

3885490

3885491

3885497

3885498

3885499

3885500

3885502

3885507

3885509

3885511

3885512

3885513

3885515

3885517

3885518

3885520

3885521

3885522

3885525

3885526

3885527

3885528

7150

8062603

A_23_P305507

A_33_P3371493

GE57478

GE60513

GO:0000228

GO:0000932

GO:0000978

GO:0001650

GO:0001673

GO:0003677

GO:0003682

GO:0003690

GO:0003697

GO:0003723

GO:0003824

GO:0003916

GO:0003917

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0006260

GO:0006265

GO:0006325

GO:0006338

GO:0007059

GO:0007623

GO:0008301

GO:0009410

GO:0012501

GO:0016310

GO:0016740

GO:0016853

GO:0018105

GO:0019904

GO:0032922

GO:0032993

GO:0036211

GO:0040016

GO:0043204

GO:0043226

GO:0048511

GO:0048856

GO:0097100

GO:0140096

GO:0140097

HMNXSV003009439

Hs.317.0.S1_3p_a_at

ILMN_1763419

ILMN_2192316

PH_hs_0040753

TC20000302.hg

TC20001221.hg

U07804_s_at

U07806_s_at

g339805_3p_a_at

Participates

as an input of

SUMOylation of TOP1 with SUMO1 (Homo sapiens)

Other forms of this molecule

monoSUMO1-K117-TOP1 [nucleoplasm]

Inferred To

top1a [nucleoplasm] (Danio rerio)

top-1 [nucleoplasm] (Caenorhabditis elegans)

Top1 [nucleoplasm] (Drosophila melanogaster)

Top1 [nucleoplasm] (Mus musculus)

Top1 [nucleoplasm] (Rattus norvegicus)

top1 [nucleoplasm] (Dictyostelium discoideum)

top1 [nucleoplasm] (Schizosaccharomyces pombe)

top1 [nucleoplasm] (Xenopus tropicalis)

TOP1 [nucleoplasm] (Bos taurus)

TOP1 [nucleoplasm] (Canis familiaris)

TOP1 [nucleoplasm] (Gallus gallus)

TOP1 [nucleoplasm] (Plasmodium falciparum)

TOP1 [nucleoplasm] (Saccharomyces cerevisiae)

TOP1 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_003277.1

ZINC - World Drugs

TOP1_HUMAN

Guide to Pharmacology - Targets

2636

OpenTargets

ENSG00000198900

ZINC - FDA approved

TOP1_HUMAN

ZINC - Substances

TOP1_HUMAN

ZINC target

P11387

ZINC - Biogenic

TOP1_HUMAN

PRO

P11387

PDB

1SC7, 1RRJ, 1NH3, 1SEU, 1RR8, 1T8I, 1TL8, 1A36, 1LPQ, 1A35, 1EJ9, 1A31, 1K4T, 1K4S, 1R49

ZINC - Investigational

TOP1_HUMAN

HPA

ENSG00000198900-TOP1

GeneCards

P11387

Ensembl

ENSP00000354522, ENST00000361337, ENSG00000198900

Pharos - Targets

P11387

ZINC - Predictions - Purchasable

TOP1_HUMAN

Interactors (37)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P03070 LT			0.734	12
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.669	3
UniProt:Q99801 NKX31			0.626	6
UniProt:P00519 ABL1	6	p-Y393-ABL1 [cytosol] (R-HSA-9865161) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) ABL1 [cytosol] (R-HSA-375987) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610) ABL1 [nucleoplasm] (R-HSA-5686579) p-S456-ABL1 [nucleoplasm] (R-HSA-5686576)	0.602	7
UniProt:P09874 PARP1	4	polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) PARP1 [nucleoplasm] (R-HSA-201568)	0.597	5
UniProt:Q92841 DDX17	2	DDX17 [nucleoplasm] (R-HSA-3900090) monoSUMO1-K50-DDX17 [nucleoplasm] (R-HSA-3900104)	0.597	4
UniProt:P09651 HNRNPA1	2	HNRNPA1 [cytosol] (R-HSA-9727902) HNRNPA1 [nucleoplasm] (R-HSA-71927)	0.597	4
UniProt:Q15717 ELAVL1	6	ELAVL1 [nucleoplasm] (R-HSA-450601) p-S158,S221-ELAVL1 [nucleoplasm] (R-HSA-450576) p-S221,S318-ELAVL1 [nucleoplasm] (R-HSA-450532) ELAVL1 [cytosol] (R-HSA-450582) p-S221,S318-ELAVL1 [cytosol] (R-HSA-450448) p-S158,S221-ELAVL1 [cytosol] (R-HSA-450376)	0.597	4
UniProt:P78527 PRKDC	4	K48polyUb-PRKDC [cytosol] (R-HSA-8938766) PRKDC [cytosol] (R-HSA-3134816) p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-HSA-76302) PRKDC [nucleoplasm] (R-HSA-62161)	0.597	3
UniProt:Q08211 DHX9	3	DHX9 [nucleoplasm] (R-HSA-53517) DHX9 [cytosol] (R-HSA-847700) p-DHX9 [cytosol] (R-HSA-9836168)	0.597	4
UniProt:P61978 HNRNPK	2	polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532) HNRNPK [nucleoplasm] (R-HSA-71945)	0.597	3
UniProt:Q15233 NONO			0.597	3
UniProt:Q6P2Q9 PRPF8	1	PRPF8 [nucleoplasm] (R-HSA-83810)	0.597	3
UniProt:P22626 HNRNPA2B1	2	HNRNPA2B1 [extracellular exosome] (R-HSA-8950304) HNRNPA2B1 [nucleoplasm] (R-HSA-71929)	0.597	4
UniProt:P11388 TOP2A	3	TOP2A [nucleoplasm] (R-HSA-1362276) polySUMO2,3-TOP2A [nucleoplasm] (R-HSA-4641298) monoSUMO1-K-TOP2A [nucleoplasm] (R-HSA-4641367)	0.597	4
UniProt:O43390 HNRNPR	1	HNRNPR [nucleoplasm] (R-HSA-71951)	0.597	4
UniProt:O75643 SNRNP200	1	SNRNP200 [nucleoplasm] (R-HSA-71885)	0.597	3
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.597	4
UniProt:P23246 SFPQ	3	SFPQ [cytosol] (R-HSA-9635505) p-Y-SFPQ [nucleoplasm] (R-HSA-8849461) SFPQ [nucleoplasm] (R-HSA-3900138)	0.597	3
UniProt:Q00839 HNRNPU	1	HNRNPU [nucleoplasm] (R-HSA-71953)	0.597	4
UniProt:P07910 HNRNPC	3	HNRNPC [cytosol] (R-HSA-9715136) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [nucleoplasm] (R-HSA-71933)	0.597	4
UniProt:P19338 NCL	3	NCL [plasma membrane] (R-HSA-9836466) NCL [macropinosome membrane] (R-HSA-9837666) NCL [nucleoplasm] (R-HSA-6791213)	0.59	3
UniProt:P13010 XRCC5	4	XRCC5 [extracellular region] (R-HSA-6806530) XRCC5 [secretory granule lumen] (R-HSA-6801297) XRCC5 [cytosol] (R-HSA-3134849) XRCC5 [nucleoplasm] (R-HSA-58274)	0.564	2
UniProt:P42768 WAS	2	WAS [cytosol] (R-HSA-201879) p-Y291-WAS [cytosol] (R-HSA-2197668)	0.558	3
UniProt:P14866 HNRNPL	1	HNRNPL [nucleoplasm] (R-HSA-71947)	0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q96SB4 SRPK1	2	SRPK1 [nucleoplasm] (R-HSA-9821984) SRPK1 [cytosol] (R-HSA-9729349)	0.527	2
UniProt:P17844 DDX5	4	DDX5 [nucleoplasm] (R-HSA-3900136) DDX5 [cytosol] (R-HSA-9682643) polySUMO2-K53-DDX5 [nucleoplasm] (R-HSA-3900186) monoSUMO1-K53-DDX5 [nucleoplasm] (R-HSA-3900041)	0.527	3
UniProt:P51991 HNRNPA3	1	HNRNPA3 [nucleoplasm] (R-HSA-71931)	0.527	2
UniProt:Q9BUQ8 DDX23	1	DDX23 [nucleoplasm] (R-HSA-71879)	0.527	2
UniProt:Q96JC9 EAF1	1	EAF1 [nucleoplasm] (R-HSA-8932787)	0.527	2
UniProt:Q15029 EFTUD2	1	EFTUD2 [nucleoplasm] (R-HSA-71883)	0.527	2
UniProt:P16403 H1-2	1	HIST1H1C [nucleoplasm] (R-HSA-211237)	0.462	3
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2
UniProt:P09661 SNRPA1	1	SNRPA1 [nucleoplasm] (R-HSA-71958)	0.462	2
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.462	3
UniProt:Q07955 SRSF1	1	SRSF1 [nucleoplasm] (R-HSA-72031)	0.462	3

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